Novel phenolic compound from Southern Ocean microalgae Chlorella sp. PR-1 and its antibacterial activity

ABSTRACT Marine microalgae has been attracting the researcher’s attention for centuries. Development on microalgal research is majorly favoured by its medicinal, pharmaceutical or cosmeceutical properties. The advancement in the investigation related to microalgal products have been concen...

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Autores principales:	Gupta,Pratibha, Banerjee,Aparna, Castillo,Alexis, Bandopadhyay,Rajib
Lenguaje:	English
Publicado:	Facultad de Ciencias Naturales y Oceanográficas, Universidad de Concepción 2021
Materias:	antibacterial activity microalgae phenolic compound Southern Ocean
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-66432021000100029
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spelling	oai:scielo:S0717-664320210001000292021-10-14Novel phenolic compound from Southern Ocean microalgae Chlorella sp. PR-1 and its antibacterial activityGupta,PratibhaBanerjee,AparnaCastillo,AlexisBandopadhyay,Rajib antibacterial activity microalgae phenolic compound Southern Ocean ABSTRACT Marine microalgae has been attracting the researcher’s attention for centuries. Development on microalgal research is majorly favoured by its medicinal, pharmaceutical or cosmeceutical properties. The advancement in the investigation related to microalgal products have been concentrated in the coastal zones because of the greater supply of raw material. The Southern Ocean, highly productive and relatively poorly studied ecosystem, constitutes approximately 10% of the global volume of the oceans. In this study, marine microalgae Chlorella sp. PR-1 was isolated from the Southern Ocean (Indian Sector) for the identification of bioactive antibacterial compounds. The antimicrobial activity of this microalgal extracts was evaluated against three gram positive (Staphylococcus aureus, Bacillus licheniformis, and Bacillus subtilis) and three gram negative bacteria (Pseudomonas aeruginosa, Salmonella typhimurium, and Escherichia coli). The extract showing antibacterial activity was further purified by thin layer and column chromatography. The antimicrobial activity was again evaluated and confirmed with the purified fraction against the same bacteria. The identification of the functional groups in the purified fraction was performed by infrared spectroscopic analysis. Based on gas chromatographic and mass spectroscopic analysis, the principle bioactive compound was proved to be 2,4-bis (1,1-dimethylethyl)- phenol. Thus, the bioactive compound isolated from marine microalga of Southern Ocean origin may be a novel alternative source of antibacterials in the future.info:eu-repo/semantics/openAccessFacultad de Ciencias Naturales y Oceanográficas, Universidad de ConcepciónGayana. Botánica v.78 n.1 20212021-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-66432021000100029en10.4067/S0717-66432021000100029
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	antibacterial activity microalgae phenolic compound Southern Ocean
spellingShingle	antibacterial activity microalgae phenolic compound Southern Ocean Gupta,Pratibha Banerjee,Aparna Castillo,Alexis Bandopadhyay,Rajib Novel phenolic compound from Southern Ocean microalgae Chlorella sp. PR-1 and its antibacterial activity
description	ABSTRACT Marine microalgae has been attracting the researcher’s attention for centuries. Development on microalgal research is majorly favoured by its medicinal, pharmaceutical or cosmeceutical properties. The advancement in the investigation related to microalgal products have been concentrated in the coastal zones because of the greater supply of raw material. The Southern Ocean, highly productive and relatively poorly studied ecosystem, constitutes approximately 10% of the global volume of the oceans. In this study, marine microalgae Chlorella sp. PR-1 was isolated from the Southern Ocean (Indian Sector) for the identification of bioactive antibacterial compounds. The antimicrobial activity of this microalgal extracts was evaluated against three gram positive (Staphylococcus aureus, Bacillus licheniformis, and Bacillus subtilis) and three gram negative bacteria (Pseudomonas aeruginosa, Salmonella typhimurium, and Escherichia coli). The extract showing antibacterial activity was further purified by thin layer and column chromatography. The antimicrobial activity was again evaluated and confirmed with the purified fraction against the same bacteria. The identification of the functional groups in the purified fraction was performed by infrared spectroscopic analysis. Based on gas chromatographic and mass spectroscopic analysis, the principle bioactive compound was proved to be 2,4-bis (1,1-dimethylethyl)- phenol. Thus, the bioactive compound isolated from marine microalga of Southern Ocean origin may be a novel alternative source of antibacterials in the future.
author	Gupta,Pratibha Banerjee,Aparna Castillo,Alexis Bandopadhyay,Rajib
author_facet	Gupta,Pratibha Banerjee,Aparna Castillo,Alexis Bandopadhyay,Rajib
author_sort	Gupta,Pratibha
title	Novel phenolic compound from Southern Ocean microalgae Chlorella sp. PR-1 and its antibacterial activity
title_short	Novel phenolic compound from Southern Ocean microalgae Chlorella sp. PR-1 and its antibacterial activity
title_full	Novel phenolic compound from Southern Ocean microalgae Chlorella sp. PR-1 and its antibacterial activity
title_fullStr	Novel phenolic compound from Southern Ocean microalgae Chlorella sp. PR-1 and its antibacterial activity
title_full_unstemmed	Novel phenolic compound from Southern Ocean microalgae Chlorella sp. PR-1 and its antibacterial activity
title_sort	novel phenolic compound from southern ocean microalgae chlorella sp. pr-1 and its antibacterial activity
publisher	Facultad de Ciencias Naturales y Oceanográficas, Universidad de Concepción
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-66432021000100029
work_keys_str_mv	AT guptapratibha novelphenoliccompoundfromsouthernoceanmicroalgaechlorellasppr1anditsantibacterialactivity AT banerjeeaparna novelphenoliccompoundfromsouthernoceanmicroalgaechlorellasppr1anditsantibacterialactivity AT castilloalexis novelphenoliccompoundfromsouthernoceanmicroalgaechlorellasppr1anditsantibacterialactivity AT bandopadhyayrajib novelphenoliccompoundfromsouthernoceanmicroalgaechlorellasppr1anditsantibacterialactivity
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Novel phenolic compound from Southern Ocean microalgae Chlorella sp. PR-1 and its antibacterial activity

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