POROTIC HYPEROSTOSIS AS A MANIFESTATION OF IRON DEFICIENCY?

Presence of porotic hyperostosis has been frequently used in the anthropologic literature as evidence of iron deficiency anemia. This perspective appears to represent a hypothesis that may not have been adequately tested. Any process which increases marrow activity (evidenced by porotic hyperostosis...

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Autor principal:	Rothschild,Bruce M.
Lenguaje:	English
Publicado:	Universidad de Tarapacá. Facultad de Ciencias Sociales y Jurídicas. Departamento de Antropología 2000
Materias:	Iron deficiency porotic hyperostosis hemolysis parasitism
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-73562000000100014
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spelling	oai:scielo:S0717-735620000001000142006-01-04POROTIC HYPEROSTOSIS AS A MANIFESTATION OF IRON DEFICIENCY?Rothschild,Bruce M. Iron deficiency porotic hyperostosis hemolysis parasitism Presence of porotic hyperostosis has been frequently used in the anthropologic literature as evidence of iron deficiency anemia. This perspective appears to represent a hypothesis that may not have been adequately tested. Any process which increases marrow activity (evidenced by porotic hyperostosis) increases consumption of basic nutrients. Iron stores, often low to begin with, are typically the most rapidly depleted. Thus, individuals with hemoglobinopathies or hemolytic anemia develop the "hair on end" phenomenon and only subsequently become deficient of iron. Even those clinical reports (which claim occurrence of diploic skull changes in patients with iron deficiency) report a very low frequency of the phenomenon. The only identified study of the frequency of skull changes in iron deficiency (Agarwal et al. 1970) revealed a frequency of only 0.68%! This certainly does not support iron deficiency as the explanation for the high frequency of porotic hyperostosis noted (approximating 50%) in some populations. There is also no relationship of degree of anemia or of iron deficiency to occurrence of the "hair on end" phenomenon of porotic hyperostosis. What then is the significance of porotic hyperostosis?. Ascribing high population frequency occurrence of porotic hyperostosis to iron deficiency anemia no longer seems tenable. Perhaps further exploration of presence of genetic hemolytic anemias, parasite exposure, hemoglobinopathies, and nutritional bases will prove enlighteninginfo:eu-repo/semantics/openAccessUniversidad de Tarapacá. Facultad de Ciencias Sociales y Jurídicas. Departamento de AntropologíaChungará (Arica) v.32 n.1 20002000-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-73562000000100014en10.4067/S0717-73562000000100014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Iron deficiency porotic hyperostosis hemolysis parasitism
spellingShingle	Iron deficiency porotic hyperostosis hemolysis parasitism Rothschild,Bruce M. POROTIC HYPEROSTOSIS AS A MANIFESTATION OF IRON DEFICIENCY?
description	Presence of porotic hyperostosis has been frequently used in the anthropologic literature as evidence of iron deficiency anemia. This perspective appears to represent a hypothesis that may not have been adequately tested. Any process which increases marrow activity (evidenced by porotic hyperostosis) increases consumption of basic nutrients. Iron stores, often low to begin with, are typically the most rapidly depleted. Thus, individuals with hemoglobinopathies or hemolytic anemia develop the "hair on end" phenomenon and only subsequently become deficient of iron. Even those clinical reports (which claim occurrence of diploic skull changes in patients with iron deficiency) report a very low frequency of the phenomenon. The only identified study of the frequency of skull changes in iron deficiency (Agarwal et al. 1970) revealed a frequency of only 0.68%! This certainly does not support iron deficiency as the explanation for the high frequency of porotic hyperostosis noted (approximating 50%) in some populations. There is also no relationship of degree of anemia or of iron deficiency to occurrence of the "hair on end" phenomenon of porotic hyperostosis. What then is the significance of porotic hyperostosis?. Ascribing high population frequency occurrence of porotic hyperostosis to iron deficiency anemia no longer seems tenable. Perhaps further exploration of presence of genetic hemolytic anemias, parasite exposure, hemoglobinopathies, and nutritional bases will prove enlightening
author	Rothschild,Bruce M.
author_facet	Rothschild,Bruce M.
author_sort	Rothschild,Bruce M.
title	POROTIC HYPEROSTOSIS AS A MANIFESTATION OF IRON DEFICIENCY?
title_short	POROTIC HYPEROSTOSIS AS A MANIFESTATION OF IRON DEFICIENCY?
title_full	POROTIC HYPEROSTOSIS AS A MANIFESTATION OF IRON DEFICIENCY?
title_fullStr	POROTIC HYPEROSTOSIS AS A MANIFESTATION OF IRON DEFICIENCY?
title_full_unstemmed	POROTIC HYPEROSTOSIS AS A MANIFESTATION OF IRON DEFICIENCY?
title_sort	porotic hyperostosis as a manifestation of iron deficiency?
publisher	Universidad de Tarapacá. Facultad de Ciencias Sociales y Jurídicas. Departamento de Antropología
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-73562000000100014
work_keys_str_mv	AT rothschildbrucem porotichyperostosisasamanifestationofirondeficiency
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POROTIC HYPEROSTOSIS AS A MANIFESTATION OF IRON DEFICIENCY?

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