Calcium as a nutrient involved in the synthesis and localization of proteins that facilitate iron uptake and efflux in enterocytes
Iron deficiency is the most common type of nutritional deficiency in the world, and calcium intake is low in many populations. Developing a supplement that contains both micronutrients would be an excellent method to prevent iron deficiency and increase calcium intake. Human and cellular studies hav...
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Sociedad Chilena de Nutrición, Bromatología y Toxicología
2015
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oai:scielo:S0717-751820150004000112016-03-02Calcium as a nutrient involved in the synthesis and localization of proteins that facilitate iron uptake and efflux in enterocytesHerrera M,JuliánParra S,Beatriz ECorrales A,VanessaOlivares G,ManuelPizarro A,FernandoGaitán Ch,Diego iron uptake efflux absorption calcium Caco-2 Iron deficiency is the most common type of nutritional deficiency in the world, and calcium intake is low in many populations. Developing a supplement that contains both micronutrients would be an excellent method to prevent iron deficiency and increase calcium intake. Human and cellular studies have shown that calcium inhibits iron absorption. Currently, the mechanisms underlying this inhibitory effect have not been elucidated. Because calcium is involved in cell signaling pathways, it may affect the regulation of the expression or localization of proteins involved in iron uptake and efflux in enterocytes. The aim of this review was to describe the processes involved in the absorption of dietary iron and the regulation of the expression and activity of proteins involved in this absorption. Additionally, the potential mechanisms by which calcium affects the expression and localization of these proteins are also discussed.info:eu-repo/semantics/openAccessSociedad Chilena de Nutrición, Bromatología y ToxicologíaRevista chilena de nutrición v.42 n.4 20152015-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182015000400011en10.4067/S0717-75182015000400011 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
iron uptake efflux absorption calcium Caco-2 |
| spellingShingle |
iron uptake efflux absorption calcium Caco-2 Herrera M,Julián Parra S,Beatriz E Corrales A,Vanessa Olivares G,Manuel Pizarro A,Fernando Gaitán Ch,Diego Calcium as a nutrient involved in the synthesis and localization of proteins that facilitate iron uptake and efflux in enterocytes |
| description |
Iron deficiency is the most common type of nutritional deficiency in the world, and calcium intake is low in many populations. Developing a supplement that contains both micronutrients would be an excellent method to prevent iron deficiency and increase calcium intake. Human and cellular studies have shown that calcium inhibits iron absorption. Currently, the mechanisms underlying this inhibitory effect have not been elucidated. Because calcium is involved in cell signaling pathways, it may affect the regulation of the expression or localization of proteins involved in iron uptake and efflux in enterocytes. The aim of this review was to describe the processes involved in the absorption of dietary iron and the regulation of the expression and activity of proteins involved in this absorption. Additionally, the potential mechanisms by which calcium affects the expression and localization of these proteins are also discussed. |
| author |
Herrera M,Julián Parra S,Beatriz E Corrales A,Vanessa Olivares G,Manuel Pizarro A,Fernando Gaitán Ch,Diego |
| author_facet |
Herrera M,Julián Parra S,Beatriz E Corrales A,Vanessa Olivares G,Manuel Pizarro A,Fernando Gaitán Ch,Diego |
| author_sort |
Herrera M,Julián |
| title |
Calcium as a nutrient involved in the synthesis and localization of proteins that facilitate iron uptake and efflux in enterocytes |
| title_short |
Calcium as a nutrient involved in the synthesis and localization of proteins that facilitate iron uptake and efflux in enterocytes |
| title_full |
Calcium as a nutrient involved in the synthesis and localization of proteins that facilitate iron uptake and efflux in enterocytes |
| title_fullStr |
Calcium as a nutrient involved in the synthesis and localization of proteins that facilitate iron uptake and efflux in enterocytes |
| title_full_unstemmed |
Calcium as a nutrient involved in the synthesis and localization of proteins that facilitate iron uptake and efflux in enterocytes |
| title_sort |
calcium as a nutrient involved in the synthesis and localization of proteins that facilitate iron uptake and efflux in enterocytes |
| publisher |
Sociedad Chilena de Nutrición, Bromatología y Toxicología |
| publishDate |
2015 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182015000400011 |
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