The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice

ABSTRACT Neutropenia is one of the adverse effects caused by the administration of chemotherapy drugs. The present study aimed at investigating the effect of vitamin C supplementation in a model of immunosuppression induced by cyclophosphamide in mice. Vitamin C supplementation (50 mg/kg/day) admini...

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Autores principales:	Garcia,Rosane Scussel, Araújo,Évelyn de Souza, Dambrós,Betina Fernanda, Schneider,Augusto, Abib,Renata Torres
Lenguaje:	English
Publicado:	Sociedad Chilena de Nutrición, Bromatología y Toxicología 2019
Materias:	Cyclophosphamide Immunosuppression Vitamin C Weight loss
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182019000200168
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spelling	oai:scielo:S0717-751820190002001682019-04-02The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in miceGarcia,Rosane ScusselAraújo,Évelyn de SouzaDambrós,Betina FernandaSchneider,AugustoAbib,Renata Torres Cyclophosphamide Immunosuppression Vitamin C Weight loss ABSTRACT Neutropenia is one of the adverse effects caused by the administration of chemotherapy drugs. The present study aimed at investigating the effect of vitamin C supplementation in a model of immunosuppression induced by cyclophosphamide in mice. Vitamin C supplementation (50 mg/kg/day) administered intraperitoneally (i.p.) for 7 consecutive days in adult Swiss albino female. Mice were divided into four groups (n= 8/group): 1. Control (only distilled water i.p.), 2. Cyclophosphamide group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and distilled water daily), 3. Vitamin C group (Vitamin C 50 mg/kg i.p. and distilled water daily), and 4. Cyclophosphamide and Vitamin C group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and vitamin C 50 mg/kg i.p. daily). Vitamin C did not interfere in leukocytes count, but when co-administered with cyclophosphamide, significant interaction was observed, intensifying the neutropenia caused by cyclophosphamide. Vitamin C did not influence body weight during treatment, but groups receiving cyclophosphamide had a significant weight loss from the third day of treatment until the end of experiment compared to the control group. Vitamin C supplementation intensified neutropenia induced by cyclophosphamide and did not prevent weight loss induced by cyclophosphamide in mice.info:eu-repo/semantics/openAccessSociedad Chilena de Nutrición, Bromatología y ToxicologíaRevista chilena de nutrición v.46 n.2 20192019-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182019000200168en10.4067/s0717-75182019000200168
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cyclophosphamide Immunosuppression Vitamin C Weight loss
spellingShingle	Cyclophosphamide Immunosuppression Vitamin C Weight loss Garcia,Rosane Scussel Araújo,Évelyn de Souza Dambrós,Betina Fernanda Schneider,Augusto Abib,Renata Torres The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice
description	ABSTRACT Neutropenia is one of the adverse effects caused by the administration of chemotherapy drugs. The present study aimed at investigating the effect of vitamin C supplementation in a model of immunosuppression induced by cyclophosphamide in mice. Vitamin C supplementation (50 mg/kg/day) administered intraperitoneally (i.p.) for 7 consecutive days in adult Swiss albino female. Mice were divided into four groups (n= 8/group): 1. Control (only distilled water i.p.), 2. Cyclophosphamide group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and distilled water daily), 3. Vitamin C group (Vitamin C 50 mg/kg i.p. and distilled water daily), and 4. Cyclophosphamide and Vitamin C group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and vitamin C 50 mg/kg i.p. daily). Vitamin C did not interfere in leukocytes count, but when co-administered with cyclophosphamide, significant interaction was observed, intensifying the neutropenia caused by cyclophosphamide. Vitamin C did not influence body weight during treatment, but groups receiving cyclophosphamide had a significant weight loss from the third day of treatment until the end of experiment compared to the control group. Vitamin C supplementation intensified neutropenia induced by cyclophosphamide and did not prevent weight loss induced by cyclophosphamide in mice.
author	Garcia,Rosane Scussel Araújo,Évelyn de Souza Dambrós,Betina Fernanda Schneider,Augusto Abib,Renata Torres
author_facet	Garcia,Rosane Scussel Araújo,Évelyn de Souza Dambrós,Betina Fernanda Schneider,Augusto Abib,Renata Torres
author_sort	Garcia,Rosane Scussel
title	The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice
title_short	The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice
title_full	The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice
title_fullStr	The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice
title_full_unstemmed	The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice
title_sort	effect of vitamin c supplementation on neutropenia induced by cyclophosphamide in mice
publisher	Sociedad Chilena de Nutrición, Bromatología y Toxicología
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182019000200168
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The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice

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