Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms
ABSTRACT The objective of this review was to investigate the effect of vitamin D3 supplementation on serum 25-hydroxyvitamin D concentration in individuals with single-nucleotide polymorphisms in the vitamin D receptor gene. The research was conducted on 241 articles found in the PubMed, Scopus, Sci...
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Sociedad Chilena de Nutrición, Bromatología y Toxicología
2020
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oai:scielo:S0717-751820200001001412020-02-25Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphismsNunes,Ivone Freires de Oliveira CostaRogero,Marcelo MacedoSousa,Joyce RamalhoRosa,Érica Patrícia CunhaCarvalho,Marcos David Figueiredo deOliveira,Francisco Erasmo deNascimento,Leopoldo Fabrício Marçal doCruz,Maria do Socorro Pires eCarvalho,Cecilia Maria Resende Gonçalves de BsmI FokI Randomized clinical trial Vitamin D receptor 25(OH) D ABSTRACT The objective of this review was to investigate the effect of vitamin D3 supplementation on serum 25-hydroxyvitamin D concentration in individuals with single-nucleotide polymorphisms in the vitamin D receptor gene. The research was conducted on 241 articles found in the PubMed, Scopus, Science Direct, and Cochrane Library databases between November and December 2018. After article screening, three randomized double-blind placebo-controlled clinical trials were identified as eligible for this review. Participants were Australian, Brazilian, and Chinese individuals, who ingested doses of vitamin D3 ranging from 2000 IU to a megadose of 200,000 IU. The presence of the BB/Bb genotype of the BsmI polymorphism and the FokI G allele caused an increase in the serum concentrations of vitamin D after supplementation. Nonetheless, the few studies on this subject are not unanimous in their results. It is possible that differences among populations, sample sizes, doses, and time of supplementation have an impact on data and outcomes.info:eu-repo/semantics/openAccessSociedad Chilena de Nutrición, Bromatología y ToxicologíaRevista chilena de nutrición v.47 n.1 20202020-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182020000100141en10.4067/S0717-75182020000100141 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
BsmI FokI Randomized clinical trial Vitamin D receptor 25(OH) D |
| spellingShingle |
BsmI FokI Randomized clinical trial Vitamin D receptor 25(OH) D Nunes,Ivone Freires de Oliveira Costa Rogero,Marcelo Macedo Sousa,Joyce Ramalho Rosa,Érica Patrícia Cunha Carvalho,Marcos David Figueiredo de Oliveira,Francisco Erasmo de Nascimento,Leopoldo Fabrício Marçal do Cruz,Maria do Socorro Pires e Carvalho,Cecilia Maria Resende Gonçalves de Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms |
| description |
ABSTRACT The objective of this review was to investigate the effect of vitamin D3 supplementation on serum 25-hydroxyvitamin D concentration in individuals with single-nucleotide polymorphisms in the vitamin D receptor gene. The research was conducted on 241 articles found in the PubMed, Scopus, Science Direct, and Cochrane Library databases between November and December 2018. After article screening, three randomized double-blind placebo-controlled clinical trials were identified as eligible for this review. Participants were Australian, Brazilian, and Chinese individuals, who ingested doses of vitamin D3 ranging from 2000 IU to a megadose of 200,000 IU. The presence of the BB/Bb genotype of the BsmI polymorphism and the FokI G allele caused an increase in the serum concentrations of vitamin D after supplementation. Nonetheless, the few studies on this subject are not unanimous in their results. It is possible that differences among populations, sample sizes, doses, and time of supplementation have an impact on data and outcomes. |
| author |
Nunes,Ivone Freires de Oliveira Costa Rogero,Marcelo Macedo Sousa,Joyce Ramalho Rosa,Érica Patrícia Cunha Carvalho,Marcos David Figueiredo de Oliveira,Francisco Erasmo de Nascimento,Leopoldo Fabrício Marçal do Cruz,Maria do Socorro Pires e Carvalho,Cecilia Maria Resende Gonçalves de |
| author_facet |
Nunes,Ivone Freires de Oliveira Costa Rogero,Marcelo Macedo Sousa,Joyce Ramalho Rosa,Érica Patrícia Cunha Carvalho,Marcos David Figueiredo de Oliveira,Francisco Erasmo de Nascimento,Leopoldo Fabrício Marçal do Cruz,Maria do Socorro Pires e Carvalho,Cecilia Maria Resende Gonçalves de |
| author_sort |
Nunes,Ivone Freires de Oliveira Costa |
| title |
Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms |
| title_short |
Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms |
| title_full |
Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms |
| title_fullStr |
Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms |
| title_full_unstemmed |
Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms |
| title_sort |
effect of vitamin d3 supplementation on 25 ohd plasma levels in the presence of vdr gene polymorphisms |
| publisher |
Sociedad Chilena de Nutrición, Bromatología y Toxicología |
| publishDate |
2020 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182020000100141 |
| work_keys_str_mv |
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1718443723000381440 |