Warfarin drug interaction with vitamin K and other foodstuffs

ABSTRACT Vitamin K is found in higher concentrations in dark green plant and in vegetable oils. The adequate intake of vitamin K is 90 and 120μg/day for adult elderly men and women, respectively. The main function of vitamin K is to act as an enzymatic cofactor for hepatic prothrombin synth...

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Autores principales:	Minighin,Elaine C., Bragança,Kellen P., Anastácio,Lucilene R.
Lenguaje:	English
Publicado:	Sociedad Chilena de Nutrición, Bromatología y Toxicología 2020
Materias:	Drug-food interaction International Normalized Ratio Phylloquinone Sources Warfarin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182020000300470
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spelling	oai:scielo:S0717-751820200003004702020-06-22Warfarin drug interaction with vitamin K and other foodstuffsMinighin,Elaine C.Bragança,Kellen P.Anastácio,Lucilene R. Drug-food interaction International Normalized Ratio Phylloquinone Sources Warfarin ABSTRACT Vitamin K is found in higher concentrations in dark green plant and in vegetable oils. The adequate intake of vitamin K is 90 and 120μg/day for adult elderly men and women, respectively. The main function of vitamin K is to act as an enzymatic cofactor for hepatic prothrombin synthesis, blood coagulation factors, and anticoagulant proteins. Prominent among the many available anticoagulants is warfarin, an antagonist of vitamin K, which exerts its anticoagulant effects by inhibiting the synthesis of vitamin K1 and vitamin KH2. From the beginning of the therapy it is necessary that the patients carry out the monitoring through the prothrombin time and the international normalized ratio. However, it is known that very low intake and/or fluctuations in vitamin K intake are as harmful as high consumption. In addition, other foods can interact with warfarin, despite their content of vitamin K. The aim of this study was to gather information on the drug interaction of warfarin with vitamin K and with dietary supplements and other foods.info:eu-repo/semantics/openAccessSociedad Chilena de Nutrición, Bromatología y ToxicologíaRevista chilena de nutrición v.47 n.3 20202020-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182020000300470en10.4067/S0717-75182020000300470
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Drug-food interaction International Normalized Ratio Phylloquinone Sources Warfarin
spellingShingle	Drug-food interaction International Normalized Ratio Phylloquinone Sources Warfarin Minighin,Elaine C. Bragança,Kellen P. Anastácio,Lucilene R. Warfarin drug interaction with vitamin K and other foodstuffs
description	ABSTRACT Vitamin K is found in higher concentrations in dark green plant and in vegetable oils. The adequate intake of vitamin K is 90 and 120μg/day for adult elderly men and women, respectively. The main function of vitamin K is to act as an enzymatic cofactor for hepatic prothrombin synthesis, blood coagulation factors, and anticoagulant proteins. Prominent among the many available anticoagulants is warfarin, an antagonist of vitamin K, which exerts its anticoagulant effects by inhibiting the synthesis of vitamin K1 and vitamin KH2. From the beginning of the therapy it is necessary that the patients carry out the monitoring through the prothrombin time and the international normalized ratio. However, it is known that very low intake and/or fluctuations in vitamin K intake are as harmful as high consumption. In addition, other foods can interact with warfarin, despite their content of vitamin K. The aim of this study was to gather information on the drug interaction of warfarin with vitamin K and with dietary supplements and other foods.
author	Minighin,Elaine C. Bragança,Kellen P. Anastácio,Lucilene R.
author_facet	Minighin,Elaine C. Bragança,Kellen P. Anastácio,Lucilene R.
author_sort	Minighin,Elaine C.
title	Warfarin drug interaction with vitamin K and other foodstuffs
title_short	Warfarin drug interaction with vitamin K and other foodstuffs
title_full	Warfarin drug interaction with vitamin K and other foodstuffs
title_fullStr	Warfarin drug interaction with vitamin K and other foodstuffs
title_full_unstemmed	Warfarin drug interaction with vitamin K and other foodstuffs
title_sort	warfarin drug interaction with vitamin k and other foodstuffs
publisher	Sociedad Chilena de Nutrición, Bromatología y Toxicología
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182020000300470
work_keys_str_mv	AT minighinelainec warfarindruginteractionwithvitaminkandotherfoodstuffs AT bragancakellenp warfarindruginteractionwithvitaminkandotherfoodstuffs AT anastaciolucilener warfarindruginteractionwithvitaminkandotherfoodstuffs
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Warfarin drug interaction with vitamin K and other foodstuffs

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