Role of interferon - g on the immunosuppression during Toxoplasma gondii infection by Trypanosoma lewisi

On the basis of previous studies on Trypanosoma lewisi immunosuppression model groups of 5 Wistar rats were infected with. T. gondii and T. lewisi according to the following protocol. One group was inoculated i.p. with 10(6) T. lewisi tripanomastigotes and 4 days later with 10(7) T. gondii tachyzoit...

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Autores principales:	CHINCHILLA,MISAEL, REYES,LILLIANA, GUERRERO,OLGA MARTA, CASTRO,ALFREDO
Lenguaje:	English
Publicado:	Sociedad Chilena de Parasitología 2005
Materias:	Interferon g immunosuppression Toxoplasma gondii Trypanosoma lewisi white rats natural resistance
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-77122005000100008
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spelling	oai:scielo:S0717-771220050001000082005-07-18Role of interferon - g on the immunosuppression during Toxoplasma gondii infection by Trypanosoma lewisiCHINCHILLA,MISAELREYES,LILLIANAGUERRERO,OLGA MARTACASTRO,ALFREDO Interferon g immunosuppression Toxoplasma gondii Trypanosoma lewisi white rats natural resistance On the basis of previous studies on Trypanosoma lewisi immunosuppression model groups of 5 Wistar rats were infected with. T. gondii and T. lewisi according to the following protocol. One group was inoculated i.p. with 10(6) T. lewisi tripanomastigotes and 4 days later with 10(7) T. gondii tachyzoites. The second and third groups were infected only with T. lewisi or T. gondii respectively. The fourth group was not infected and served as control. Rats were bled before the infection and then every day for seven days. Serum samples were collected and the levels of IFN-g, IL-2 and TNF-a were measured. The results indicates that the level of IFN-g is very high 24 hour after infection in rats inoculated with T. gondii only, while in those animals infected with both parasites (first group), IFN-g was not detected 24 hours after infections with T. gondii. These data give evidence that a reduction of IFN-g levels is one of the reasons for the immunosuppressive effect induced by T. lewisi, increasing T. gondii multiplication in an animal as the rat, which is remarkable resistant to this parasiteinfo:eu-repo/semantics/openAccessSociedad Chilena de ParasitologíaParasitología latinoamericana v.60 n.1-2 20052005-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-77122005000100008en10.4067/S0717-77122005000100008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Interferon g immunosuppression Toxoplasma gondii Trypanosoma lewisi white rats natural resistance
spellingShingle	Interferon g immunosuppression Toxoplasma gondii Trypanosoma lewisi white rats natural resistance CHINCHILLA,MISAEL REYES,LILLIANA GUERRERO,OLGA MARTA CASTRO,ALFREDO Role of interferon - g on the immunosuppression during Toxoplasma gondii infection by Trypanosoma lewisi
description	On the basis of previous studies on Trypanosoma lewisi immunosuppression model groups of 5 Wistar rats were infected with. T. gondii and T. lewisi according to the following protocol. One group was inoculated i.p. with 10(6) T. lewisi tripanomastigotes and 4 days later with 10(7) T. gondii tachyzoites. The second and third groups were infected only with T. lewisi or T. gondii respectively. The fourth group was not infected and served as control. Rats were bled before the infection and then every day for seven days. Serum samples were collected and the levels of IFN-g, IL-2 and TNF-a were measured. The results indicates that the level of IFN-g is very high 24 hour after infection in rats inoculated with T. gondii only, while in those animals infected with both parasites (first group), IFN-g was not detected 24 hours after infections with T. gondii. These data give evidence that a reduction of IFN-g levels is one of the reasons for the immunosuppressive effect induced by T. lewisi, increasing T. gondii multiplication in an animal as the rat, which is remarkable resistant to this parasite
author	CHINCHILLA,MISAEL REYES,LILLIANA GUERRERO,OLGA MARTA CASTRO,ALFREDO
author_facet	CHINCHILLA,MISAEL REYES,LILLIANA GUERRERO,OLGA MARTA CASTRO,ALFREDO
author_sort	CHINCHILLA,MISAEL
title	Role of interferon - g on the immunosuppression during Toxoplasma gondii infection by Trypanosoma lewisi
title_short	Role of interferon - g on the immunosuppression during Toxoplasma gondii infection by Trypanosoma lewisi
title_full	Role of interferon - g on the immunosuppression during Toxoplasma gondii infection by Trypanosoma lewisi
title_fullStr	Role of interferon - g on the immunosuppression during Toxoplasma gondii infection by Trypanosoma lewisi
title_full_unstemmed	Role of interferon - g on the immunosuppression during Toxoplasma gondii infection by Trypanosoma lewisi
title_sort	role of interferon - g on the immunosuppression during toxoplasma gondii infection by trypanosoma lewisi
publisher	Sociedad Chilena de Parasitología
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-77122005000100008
work_keys_str_mv	AT chinchillamisael roleofinterferongontheimmunosuppressionduringtoxoplasmagondiiinfectionbytrypanosomalewisi AT reyeslilliana roleofinterferongontheimmunosuppressionduringtoxoplasmagondiiinfectionbytrypanosomalewisi AT guerreroolgamarta roleofinterferongontheimmunosuppressionduringtoxoplasmagondiiinfectionbytrypanosomalewisi AT castroalfredo roleofinterferongontheimmunosuppressionduringtoxoplasmagondiiinfectionbytrypanosomalewisi
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Role of interferon - g on the immunosuppression during Toxoplasma gondii infection by Trypanosoma lewisi

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