Trypanosoma rangeli infected mouse sera reactivity with Trypanosoma cruzi synthetic peptides

In man, differential diagnosis of Trypanosoma cruzi and Trypanosoma rangeli infections represents a serious problem, not only because both parasites present similar geographical distribution, the same hosts and sometimes the same insect vector, but also because they have common antigen determinants....

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Autores principales:	ZUNIGA,CLAUDIO, VARGAS,RAMON, PALAU,MARIA TERESA, BELLO,FELIO, DE DIEGO,JOSÉ ANTONIO, VERGARA,ULISES
Lenguaje:	English
Publicado:	Sociedad Chilena de Parasitología 2007
Materias:	Trypanosoma cruzi Trypanosoma rangeli cross-reaction
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-77122007000100001
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spelling	oai:scielo:S0717-771220070001000012007-08-10Trypanosoma rangeli infected mouse sera reactivity with Trypanosoma cruzi synthetic peptidesZUNIGA,CLAUDIOVARGAS,RAMONPALAU,MARIA TERESABELLO,FELIODE DIEGO,JOSÉ ANTONIOVERGARA,ULISES Trypanosoma cruzi Trypanosoma rangeli cross-reaction In man, differential diagnosis of Trypanosoma cruzi and Trypanosoma rangeli infections represents a serious problem, not only because both parasites present similar geographical distribution, the same hosts and sometimes the same insect vector, but also because they have common antigen determinants. In this work IgM and IgG humoral responses to T. cruzi syntethic peptides in mice infected with T. cruzi and with T. rangeli were analysed. In a immunoradiometric assay (IRMA ) 6 syntethic peptides were used, denominated as clones 1, 2, SAPA, 13, 30 and 36. The results showed that sera from infected mice with T. rangeli recognized all peptides derived from T. cruzi proteins, at IgM as well as IgG level. Reactivity with peptide SAPA is discussed as previous work indicated that SAPA is not codified in the T. rangeli genome. Our results support the suggestion that crossed reactions are due to the fact that both parasites present common antigensinfo:eu-repo/semantics/openAccessSociedad Chilena de ParasitologíaParasitología latinoamericana v.62 n.1-2 20072007-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-77122007000100001en10.4067/S0717-77122007000100001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Trypanosoma cruzi Trypanosoma rangeli cross-reaction
spellingShingle	Trypanosoma cruzi Trypanosoma rangeli cross-reaction ZUNIGA,CLAUDIO VARGAS,RAMON PALAU,MARIA TERESA BELLO,FELIO DE DIEGO,JOSÉ ANTONIO VERGARA,ULISES Trypanosoma rangeli infected mouse sera reactivity with Trypanosoma cruzi synthetic peptides
description	In man, differential diagnosis of Trypanosoma cruzi and Trypanosoma rangeli infections represents a serious problem, not only because both parasites present similar geographical distribution, the same hosts and sometimes the same insect vector, but also because they have common antigen determinants. In this work IgM and IgG humoral responses to T. cruzi syntethic peptides in mice infected with T. cruzi and with T. rangeli were analysed. In a immunoradiometric assay (IRMA ) 6 syntethic peptides were used, denominated as clones 1, 2, SAPA, 13, 30 and 36. The results showed that sera from infected mice with T. rangeli recognized all peptides derived from T. cruzi proteins, at IgM as well as IgG level. Reactivity with peptide SAPA is discussed as previous work indicated that SAPA is not codified in the T. rangeli genome. Our results support the suggestion that crossed reactions are due to the fact that both parasites present common antigens
author	ZUNIGA,CLAUDIO VARGAS,RAMON PALAU,MARIA TERESA BELLO,FELIO DE DIEGO,JOSÉ ANTONIO VERGARA,ULISES
author_facet	ZUNIGA,CLAUDIO VARGAS,RAMON PALAU,MARIA TERESA BELLO,FELIO DE DIEGO,JOSÉ ANTONIO VERGARA,ULISES
author_sort	ZUNIGA,CLAUDIO
title	Trypanosoma rangeli infected mouse sera reactivity with Trypanosoma cruzi synthetic peptides
title_short	Trypanosoma rangeli infected mouse sera reactivity with Trypanosoma cruzi synthetic peptides
title_full	Trypanosoma rangeli infected mouse sera reactivity with Trypanosoma cruzi synthetic peptides
title_fullStr	Trypanosoma rangeli infected mouse sera reactivity with Trypanosoma cruzi synthetic peptides
title_full_unstemmed	Trypanosoma rangeli infected mouse sera reactivity with Trypanosoma cruzi synthetic peptides
title_sort	trypanosoma rangeli infected mouse sera reactivity with trypanosoma cruzi synthetic peptides
publisher	Sociedad Chilena de Parasitología
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-77122007000100001
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Trypanosoma rangeli infected mouse sera reactivity with Trypanosoma cruzi synthetic peptides

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