Efecto terapéutico de las estatinas en patología degenerativa del SNC: comentario sobre una publicación experimental reciente

Statins (HMG-CoA reductase inhibitors) are widely used for the treatment of hypercholesterolemia. Statins reduce the risk of coronary pathology; they are well tolerated and have few adverse effects. During the last years mounting evidence suggest that statins could be also useful for several autoimm...

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Autor principal:	von Bernhardi,Rommy
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad de Neurología, Psiquiatría y Neurocirugía 2003
Materias:	atorvastatin MG-CoA-reductase inhibitors neurodegeneration neuroprotection stroke
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-92272003000400005
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spelling	oai:scielo:S0717-922720030004000052004-01-29Efecto terapéutico de las estatinas en patología degenerativa del SNC: comentario sobre una publicación experimental recientevon Bernhardi,Rommy atorvastatin MG-CoA-reductase inhibitors neurodegeneration neuroprotection stroke Statins (HMG-CoA reductase inhibitors) are widely used for the treatment of hypercholesterolemia. Statins reduce the risk of coronary pathology; they are well tolerated and have few adverse effects. During the last years mounting evidence suggest that statins could be also useful for several autoimmune and neurodegenerative diseases. Proposed mechanisms include effects on plasma lipoproteins, endothelial function, atheroma reduction, thrombosis and inflammation. The realization that brain ischemia produces inflammation of the brain opens a new field for discovery of novel therapeutic agents for stroke. Here, I comment on a paper from Chen et al. ("Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke", Ann Neurol 2003; 53: 743-751) that proposed that atorvastatin and simvastatin reduced tissue damage and enhanced functional outcome when administered to rats 1 day after experimental stroke. Animals treated with statins showed increases in vascular endothelial growth factor, cyclic guanosine monophosphate, angiogenesis, cell proliferation and neurogenesis, and increase in synaptophysin. Although the authors concluded that atorvastatin induced brain plasticity and had neurorestorative activity, I think that significant additional experiments are required in order to sustain some of the mechanisms proposed by them. However, evidence on the effect of statins on experimental autoimmune encephalomyelitis and other inflammatory disease is also discussed here, because they cast light on alternative mechanisms that could be responsible for the better outcome of stroke animals treated with statins. Inflammation is attractive in therapeutic terms, considering its rapid initiation, its progression for several hours after stroke and its enormous contribution to brain damageinfo:eu-repo/semantics/openAccessSociedad de Neurología, Psiquiatría y NeurocirugíaRevista chilena de neuro-psiquiatría v.41 n.4 20032003-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-92272003000400005es10.4067/S0717-92272003000400005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	atorvastatin MG-CoA-reductase inhibitors neurodegeneration neuroprotection stroke
spellingShingle	atorvastatin MG-CoA-reductase inhibitors neurodegeneration neuroprotection stroke von Bernhardi,Rommy Efecto terapéutico de las estatinas en patología degenerativa del SNC: comentario sobre una publicación experimental reciente
description	Statins (HMG-CoA reductase inhibitors) are widely used for the treatment of hypercholesterolemia. Statins reduce the risk of coronary pathology; they are well tolerated and have few adverse effects. During the last years mounting evidence suggest that statins could be also useful for several autoimmune and neurodegenerative diseases. Proposed mechanisms include effects on plasma lipoproteins, endothelial function, atheroma reduction, thrombosis and inflammation. The realization that brain ischemia produces inflammation of the brain opens a new field for discovery of novel therapeutic agents for stroke. Here, I comment on a paper from Chen et al. ("Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke", Ann Neurol 2003; 53: 743-751) that proposed that atorvastatin and simvastatin reduced tissue damage and enhanced functional outcome when administered to rats 1 day after experimental stroke. Animals treated with statins showed increases in vascular endothelial growth factor, cyclic guanosine monophosphate, angiogenesis, cell proliferation and neurogenesis, and increase in synaptophysin. Although the authors concluded that atorvastatin induced brain plasticity and had neurorestorative activity, I think that significant additional experiments are required in order to sustain some of the mechanisms proposed by them. However, evidence on the effect of statins on experimental autoimmune encephalomyelitis and other inflammatory disease is also discussed here, because they cast light on alternative mechanisms that could be responsible for the better outcome of stroke animals treated with statins. Inflammation is attractive in therapeutic terms, considering its rapid initiation, its progression for several hours after stroke and its enormous contribution to brain damage
author	von Bernhardi,Rommy
author_facet	von Bernhardi,Rommy
author_sort	von Bernhardi,Rommy
title	Efecto terapéutico de las estatinas en patología degenerativa del SNC: comentario sobre una publicación experimental reciente
title_short	Efecto terapéutico de las estatinas en patología degenerativa del SNC: comentario sobre una publicación experimental reciente
title_full	Efecto terapéutico de las estatinas en patología degenerativa del SNC: comentario sobre una publicación experimental reciente
title_fullStr	Efecto terapéutico de las estatinas en patología degenerativa del SNC: comentario sobre una publicación experimental reciente
title_full_unstemmed	Efecto terapéutico de las estatinas en patología degenerativa del SNC: comentario sobre una publicación experimental reciente
title_sort	efecto terapéutico de las estatinas en patología degenerativa del snc: comentario sobre una publicación experimental reciente
publisher	Sociedad de Neurología, Psiquiatría y Neurocirugía
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-92272003000400005
work_keys_str_mv	AT vonbernhardirommy efectoterapeuticodelasestatinasenpatologiadegenerativadelsnccomentariosobreunapublicacionexperimentalreciente
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Efecto terapéutico de las estatinas en patología degenerativa del SNC: comentario sobre una publicación experimental reciente

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