Terapia neuroprotectora de la Enfermedad de Parkinson

With the current limitations on treating Parkinsons disease, neuroprotection should be looked at as a possible way of slowing the varying processes involved in the onset of the disease. A review was made of the work of NINDS experts, who evaluated 59 drugs resulting from their Medline and Pub Med s...

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Autores principales:	Miranda,Marcelo, Azaldegui,Octavio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad de Neurología, Psiquiatría y Neurocirugía 2004
Materias:	Parkinsons Disease neuroprotective terapy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-92272004000100007
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spelling	oai:scielo:S0717-922720040001000072014-08-14Terapia neuroprotectora de la Enfermedad de ParkinsonMiranda,MarceloAzaldegui,Octavio Parkinsons Disease neuroprotective terapy With the current limitations on treating Parkinsons disease, neuroprotection should be looked at as a possible way of slowing the varying processes involved in the onset of the disease. A review was made of the work of NINDS experts, who evaluated 59 drugs resulting from their Medline and Pub Med search. Twelve drugs, those considered the most promising, were included in the final analysis. We look at such substances as caffeine, coenzyme q10, estrogens, minocycline, nicotine, rasagiline-selegiline, and ropinirole-pramipexole. These agents acted dissimilarly, but favorably, on some of the diseases processes or on its underlying pathogenesis, although the mechanisms involved and the duration of the beneficial effects were not clear. The challenge is to overcome the difficulties that make the results of the few current studies uncertain, using new methods, such as transgenic models, to maintain hope for effective future treatments.info:eu-repo/semantics/openAccessSociedad de Neurología, Psiquiatría y NeurocirugíaRevista chilena de neuro-psiquiatría v.42 n.1 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-92272004000100007es10.4067/S0717-92272004000100007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Parkinsons Disease neuroprotective terapy
spellingShingle	Parkinsons Disease neuroprotective terapy Miranda,Marcelo Azaldegui,Octavio Terapia neuroprotectora de la Enfermedad de Parkinson
description	With the current limitations on treating Parkinsons disease, neuroprotection should be looked at as a possible way of slowing the varying processes involved in the onset of the disease. A review was made of the work of NINDS experts, who evaluated 59 drugs resulting from their Medline and Pub Med search. Twelve drugs, those considered the most promising, were included in the final analysis. We look at such substances as caffeine, coenzyme q10, estrogens, minocycline, nicotine, rasagiline-selegiline, and ropinirole-pramipexole. These agents acted dissimilarly, but favorably, on some of the diseases processes or on its underlying pathogenesis, although the mechanisms involved and the duration of the beneficial effects were not clear. The challenge is to overcome the difficulties that make the results of the few current studies uncertain, using new methods, such as transgenic models, to maintain hope for effective future treatments.
author	Miranda,Marcelo Azaldegui,Octavio
author_facet	Miranda,Marcelo Azaldegui,Octavio
author_sort	Miranda,Marcelo
title	Terapia neuroprotectora de la Enfermedad de Parkinson
title_short	Terapia neuroprotectora de la Enfermedad de Parkinson
title_full	Terapia neuroprotectora de la Enfermedad de Parkinson
title_fullStr	Terapia neuroprotectora de la Enfermedad de Parkinson
title_full_unstemmed	Terapia neuroprotectora de la Enfermedad de Parkinson
title_sort	terapia neuroprotectora de la enfermedad de parkinson
publisher	Sociedad de Neurología, Psiquiatría y Neurocirugía
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-92272004000100007
work_keys_str_mv	AT mirandamarcelo terapianeuroprotectoradelaenfermedaddeparkinson AT azaldeguioctavio terapianeuroprotectoradelaenfermedaddeparkinson
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Terapia neuroprotectora de la Enfermedad de Parkinson

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