La Barrera Hemato-Encefálica en la patología del Sistema Nervioso Central: su importancia en la Respuesta Inflamatoria

Introduction. The blood-brain barrier (BBB) constitutes a well-defined structure which plays a role in the normal homeostasis of the central nervous system (CNS) and in certain disease processes affecting it. Methods. Over 50 reviews and peer-reviewed experimental publications published over the las...

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Autor principal:	von Bernhardi,Rommy
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad de Neurología, Psiquiatría y Neurocirugía 2004
Materias:	endothelial cells tight junctions glia leukocyte transmigration immune response inflammation transport células endoteliales uniones estrechas glía transmigración de leucocitos respuesta inmune inflamación transporte
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-92272004000200005
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spelling	oai:scielo:S0717-922720040002000052004-08-17La Barrera Hemato-Encefálica en la patología del Sistema Nervioso Central: su importancia en la Respuesta Inflamatoriavon Bernhardi,Rommy endothelial cells tight junctions glia leukocyte transmigration immune response inflammation transport células endoteliales uniones estrechas glía transmigración de leucocitos respuesta inmune inflamación transporte Introduction. The blood-brain barrier (BBB) constitutes a well-defined structure which plays a role in the normal homeostasis of the central nervous system (CNS) and in certain disease processes affecting it. Methods. Over 50 reviews and peer-reviewed experimental publications published over the last few years that discussed development, normal morphology and function of the BBB, function defects and its role in the development of CNS pathology were reviewed. The mechanisms determining BBB functional impairment and their effect upon CNS pathology are discussed. Results. The BBB role as a physic and metabolic barrier is to isolate the CNS from the rest of the organism. However, the BBB does not behave as a passive structure. It plays an active role in the maintenance of the normal function of the CNS. Depending on the presence of injury or some systemic signals, the integrity of the BBB can be compromised, increasing its permeability. Conclusions. The morphological and functional characteristics of the BBB are key for certain CNS diseases. It also limits their therapeutic approaches. The possibility to modify the BBB permeability in a controlled way, with spatial and temporal restrictions, potentially could change both prevention and treatment for several diseases of the CNSinfo:eu-repo/semantics/openAccessSociedad de Neurología, Psiquiatría y NeurocirugíaRevista chilena de neuro-psiquiatría v.42 n.2 20042004-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-92272004000200005es10.4067/S0717-92272004000200005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	endothelial cells tight junctions glia leukocyte transmigration immune response inflammation transport células endoteliales uniones estrechas glía transmigración de leucocitos respuesta inmune inflamación transporte
spellingShingle	endothelial cells tight junctions glia leukocyte transmigration immune response inflammation transport células endoteliales uniones estrechas glía transmigración de leucocitos respuesta inmune inflamación transporte von Bernhardi,Rommy La Barrera Hemato-Encefálica en la patología del Sistema Nervioso Central: su importancia en la Respuesta Inflamatoria
description	Introduction. The blood-brain barrier (BBB) constitutes a well-defined structure which plays a role in the normal homeostasis of the central nervous system (CNS) and in certain disease processes affecting it. Methods. Over 50 reviews and peer-reviewed experimental publications published over the last few years that discussed development, normal morphology and function of the BBB, function defects and its role in the development of CNS pathology were reviewed. The mechanisms determining BBB functional impairment and their effect upon CNS pathology are discussed. Results. The BBB role as a physic and metabolic barrier is to isolate the CNS from the rest of the organism. However, the BBB does not behave as a passive structure. It plays an active role in the maintenance of the normal function of the CNS. Depending on the presence of injury or some systemic signals, the integrity of the BBB can be compromised, increasing its permeability. Conclusions. The morphological and functional characteristics of the BBB are key for certain CNS diseases. It also limits their therapeutic approaches. The possibility to modify the BBB permeability in a controlled way, with spatial and temporal restrictions, potentially could change both prevention and treatment for several diseases of the CNS
author	von Bernhardi,Rommy
author_facet	von Bernhardi,Rommy
author_sort	von Bernhardi,Rommy
title	La Barrera Hemato-Encefálica en la patología del Sistema Nervioso Central: su importancia en la Respuesta Inflamatoria
title_short	La Barrera Hemato-Encefálica en la patología del Sistema Nervioso Central: su importancia en la Respuesta Inflamatoria
title_full	La Barrera Hemato-Encefálica en la patología del Sistema Nervioso Central: su importancia en la Respuesta Inflamatoria
title_fullStr	La Barrera Hemato-Encefálica en la patología del Sistema Nervioso Central: su importancia en la Respuesta Inflamatoria
title_full_unstemmed	La Barrera Hemato-Encefálica en la patología del Sistema Nervioso Central: su importancia en la Respuesta Inflamatoria
title_sort	la barrera hemato-encefálica en la patología del sistema nervioso central: su importancia en la respuesta inflamatoria
publisher	Sociedad de Neurología, Psiquiatría y Neurocirugía
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-92272004000200005
work_keys_str_mv	AT vonbernhardirommy labarrerahematoencefalicaenlapatologiadelsistemanerviosocentralsuimportanciaenlarespuestainflamatoria
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La Barrera Hemato-Encefálica en la patología del Sistema Nervioso Central: su importancia en la Respuesta Inflamatoria

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