ENALAPRIL AND VERAPAMIL ATTENUATE THE AORTIC WALL REMODELING IN NITRIC OXIDE DEFICIENCY

Forty mature male rats (Wistar strain) were maintained alive for 40 days, separated in four groups of five rats each (Control, L-NAME, L-NAME + Enalapril, L-NAME + Verapamil). Three aortic wall parameters were analyzed, as follows: the Q A(SMN) (the number of the tunica media smooth muscle nuclear p...

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Autores principales:	Meirelles Pereira,Leila Maria, Gonçalves Bezerra,Daniele, Mandarim-de-Lacerda,Carlos Alberto
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2003
Materias:	Nitric oxide Aorta Enalapril Verapamil Stereology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000100002
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spelling	oai:scielo:S0717-950220030001000022003-07-22ENALAPRIL AND VERAPAMIL ATTENUATE THE AORTIC WALL REMODELING IN NITRIC OXIDE DEFICIENCYMeirelles Pereira,Leila MariaGonçalves Bezerra,DanieleMandarim-de-Lacerda,Carlos Alberto Nitric oxide Aorta Enalapril Verapamil Stereology Forty mature male rats (Wistar strain) were maintained alive for 40 days, separated in four groups of five rats each (Control, L-NAME, L-NAME + Enalapril, L-NAME + Verapamil). Three aortic wall parameters were analyzed, as follows: the Q A(SMN) (the number of the tunica media smooth muscle nuclear profiles per area), the S V(lamellae) (surface density of the aortic lamellae), and the aortic wall thickness (AWT). Rats of the L-NAME group showed high blood pressure and cardiac hypertrophy. The AWT, the Q A(SMN) and the S V(lamellae) showed the same tendency among the groups. The increased AWT, or the reduced Q A(SMN) and the S V(lamellae) in l-NAME rats were not completely prevented by the administration of enalapril or verapamil. Hypertension causes the AWT increase by hypertrophy of the lamellar units of the media layer (S V(lamellae) decrease) and the following rarefaction of the smooth muscle nuclei (the Q A(SMN) decrease). The relative number of the smooth muscle cells (SMC) nuclei in L-NAME rats was not confirmed when this number was corrected by the arterial wall area. This does not support the SMC intense proliferation in animals with NO deficiency with the L-NAME dose and the duration used in this experimentation.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.21 n.1 20032003-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000100002en10.4067/S0717-95022003000100002
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Nitric oxide Aorta Enalapril Verapamil Stereology
spellingShingle	Nitric oxide Aorta Enalapril Verapamil Stereology Meirelles Pereira,Leila Maria Gonçalves Bezerra,Daniele Mandarim-de-Lacerda,Carlos Alberto ENALAPRIL AND VERAPAMIL ATTENUATE THE AORTIC WALL REMODELING IN NITRIC OXIDE DEFICIENCY
description	Forty mature male rats (Wistar strain) were maintained alive for 40 days, separated in four groups of five rats each (Control, L-NAME, L-NAME + Enalapril, L-NAME + Verapamil). Three aortic wall parameters were analyzed, as follows: the Q A(SMN) (the number of the tunica media smooth muscle nuclear profiles per area), the S V(lamellae) (surface density of the aortic lamellae), and the aortic wall thickness (AWT). Rats of the L-NAME group showed high blood pressure and cardiac hypertrophy. The AWT, the Q A(SMN) and the S V(lamellae) showed the same tendency among the groups. The increased AWT, or the reduced Q A(SMN) and the S V(lamellae) in l-NAME rats were not completely prevented by the administration of enalapril or verapamil. Hypertension causes the AWT increase by hypertrophy of the lamellar units of the media layer (S V(lamellae) decrease) and the following rarefaction of the smooth muscle nuclei (the Q A(SMN) decrease). The relative number of the smooth muscle cells (SMC) nuclei in L-NAME rats was not confirmed when this number was corrected by the arterial wall area. This does not support the SMC intense proliferation in animals with NO deficiency with the L-NAME dose and the duration used in this experimentation.
author	Meirelles Pereira,Leila Maria Gonçalves Bezerra,Daniele Mandarim-de-Lacerda,Carlos Alberto
author_facet	Meirelles Pereira,Leila Maria Gonçalves Bezerra,Daniele Mandarim-de-Lacerda,Carlos Alberto
author_sort	Meirelles Pereira,Leila Maria
title	ENALAPRIL AND VERAPAMIL ATTENUATE THE AORTIC WALL REMODELING IN NITRIC OXIDE DEFICIENCY
title_short	ENALAPRIL AND VERAPAMIL ATTENUATE THE AORTIC WALL REMODELING IN NITRIC OXIDE DEFICIENCY
title_full	ENALAPRIL AND VERAPAMIL ATTENUATE THE AORTIC WALL REMODELING IN NITRIC OXIDE DEFICIENCY
title_fullStr	ENALAPRIL AND VERAPAMIL ATTENUATE THE AORTIC WALL REMODELING IN NITRIC OXIDE DEFICIENCY
title_full_unstemmed	ENALAPRIL AND VERAPAMIL ATTENUATE THE AORTIC WALL REMODELING IN NITRIC OXIDE DEFICIENCY
title_sort	enalapril and verapamil attenuate the aortic wall remodeling in nitric oxide deficiency
publisher	Sociedad Chilena de Anatomía
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000100002
work_keys_str_mv	AT meirellespereiraleilamaria enalaprilandverapamilattenuatetheaorticwallremodelinginnitricoxidedeficiency AT goncalvesbezerradaniele enalaprilandverapamilattenuatetheaorticwallremodelinginnitricoxidedeficiency AT mandarimdelacerdacarlosalberto enalaprilandverapamilattenuatetheaorticwallremodelinginnitricoxidedeficiency
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ENALAPRIL AND VERAPAMIL ATTENUATE THE AORTIC WALL REMODELING IN NITRIC OXIDE DEFICIENCY

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