EFFECTS OF ACETYLSALICYLIC ACID ON ETHANOL-INDUCED INTRAUTERINE GROWTH RESTRICTION IN RATS
SUMMARY: The effects of acetylsalicylic acid (ASA) on intrauterine growth restriction induced by maternal ethanol consumption were studied. A single intraperitoneal dose of ethanol (2.96 g/kg body weight), injected on the 10th day of pregnancy (PD10), significantly reduced maternal weight gain, feta...
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Sociedad Chilena de Anatomía
2003
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oai:scielo:S0717-950220030002000022005-09-13EFFECTS OF ACETYLSALICYLIC ACID ON ETHANOL-INDUCED INTRAUTERINE GROWTH RESTRICTION IN RATSAparecida Marinho,SandraSala,Miguel AngelLopes,Ruberval Armandode Moraes Grisi,Márcio FernandoBelém Novaes Jr.,ArthurScombatti de Souza,Sérgio LuisTaba Jr.,Mário Rat Fetus ASA Ethanol Intrauterine development SUMMARY: The effects of acetylsalicylic acid (ASA) on intrauterine growth restriction induced by maternal ethanol consumption were studied. A single intraperitoneal dose of ethanol (2.96 g/kg body weight), injected on the 10th day of pregnancy (PD10), significantly reduced maternal weight gain, fetal weight, amniotic fluid volume and umbilical cord length. Meanwhile, ethanol did not affect placental weight or litter size. A single intraperitoneal dose of ASA (200 mg/g body weight), injected on the PD10, did not modify maternal body weight gain, litter size, fetal and placental weights and amniotic fluid volume, but significantly diminished umbilical cord length. Intraperitoneal injections of either ASA (200 mg/g body weight) or ethanol (2.96 g/kg body weight) on the PD10, demonstrated that ASA antagonized, in part at least, the effects of ethanol on maternal weight gain, fetal weight, and amniotic fluid volume. Contrarily, ASA potentiated the effect of ethanol on umbilical cord lengthinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.21 n.2 20032003-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000200002en10.4067/S0717-95022003000200002 |
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Scielo Chile |
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Scielo Chile |
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English |
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Rat Fetus ASA Ethanol Intrauterine development |
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Rat Fetus ASA Ethanol Intrauterine development Aparecida Marinho,Sandra Sala,Miguel Angel Lopes,Ruberval Armando de Moraes Grisi,Márcio Fernando Belém Novaes Jr.,Arthur Scombatti de Souza,Sérgio Luis Taba Jr.,Mário EFFECTS OF ACETYLSALICYLIC ACID ON ETHANOL-INDUCED INTRAUTERINE GROWTH RESTRICTION IN RATS |
description |
SUMMARY: The effects of acetylsalicylic acid (ASA) on intrauterine growth restriction induced by maternal ethanol consumption were studied. A single intraperitoneal dose of ethanol (2.96 g/kg body weight), injected on the 10th day of pregnancy (PD10), significantly reduced maternal weight gain, fetal weight, amniotic fluid volume and umbilical cord length. Meanwhile, ethanol did not affect placental weight or litter size. A single intraperitoneal dose of ASA (200 mg/g body weight), injected on the PD10, did not modify maternal body weight gain, litter size, fetal and placental weights and amniotic fluid volume, but significantly diminished umbilical cord length. Intraperitoneal injections of either ASA (200 mg/g body weight) or ethanol (2.96 g/kg body weight) on the PD10, demonstrated that ASA antagonized, in part at least, the effects of ethanol on maternal weight gain, fetal weight, and amniotic fluid volume. Contrarily, ASA potentiated the effect of ethanol on umbilical cord length |
author |
Aparecida Marinho,Sandra Sala,Miguel Angel Lopes,Ruberval Armando de Moraes Grisi,Márcio Fernando Belém Novaes Jr.,Arthur Scombatti de Souza,Sérgio Luis Taba Jr.,Mário |
author_facet |
Aparecida Marinho,Sandra Sala,Miguel Angel Lopes,Ruberval Armando de Moraes Grisi,Márcio Fernando Belém Novaes Jr.,Arthur Scombatti de Souza,Sérgio Luis Taba Jr.,Mário |
author_sort |
Aparecida Marinho,Sandra |
title |
EFFECTS OF ACETYLSALICYLIC ACID ON ETHANOL-INDUCED INTRAUTERINE GROWTH RESTRICTION IN RATS |
title_short |
EFFECTS OF ACETYLSALICYLIC ACID ON ETHANOL-INDUCED INTRAUTERINE GROWTH RESTRICTION IN RATS |
title_full |
EFFECTS OF ACETYLSALICYLIC ACID ON ETHANOL-INDUCED INTRAUTERINE GROWTH RESTRICTION IN RATS |
title_fullStr |
EFFECTS OF ACETYLSALICYLIC ACID ON ETHANOL-INDUCED INTRAUTERINE GROWTH RESTRICTION IN RATS |
title_full_unstemmed |
EFFECTS OF ACETYLSALICYLIC ACID ON ETHANOL-INDUCED INTRAUTERINE GROWTH RESTRICTION IN RATS |
title_sort |
effects of acetylsalicylic acid on ethanol-induced intrauterine growth restriction in rats |
publisher |
Sociedad Chilena de Anatomía |
publishDate |
2003 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000200002 |
work_keys_str_mv |
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1718444547266052096 |