PROGRESSIVE EFFECTS OF DIABETES MELLITUS ON THE SKIN EPITHELIUM OF THE RA

Skin serves as interface between inner aand outer environment, and acts a a mechanical barrier. Changes in its characteristics may lead to a higher pathogenicity, less defense capacity, or both. Diabetes mellitus is a heterogeneous group of chronic hyperglycemic disorders, considered a syndrome rath...

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Autores principales:	Benetti Tanga,Marcelo, Buttros,Kemli Raquel, Nakao,Cristiano, Chinali Komesu,Marilena
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2003
Materias:	Diabetes mellitus Hyperglycemia Skin Rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000200008
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id	oai:scielo:S0717-95022003000200008
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spelling	oai:scielo:S0717-950220030002000082005-09-13PROGRESSIVE EFFECTS OF DIABETES MELLITUS ON THE SKIN EPITHELIUM OF THE RABenetti Tanga,MarceloButtros,Kemli RaquelNakao,CristianoChinali Komesu,Marilena Diabetes mellitus Hyperglycemia Skin Rat Skin serves as interface between inner aand outer environment, and acts a a mechanical barrier. Changes in its characteristics may lead to a higher pathogenicity, less defense capacity, or both. Diabetes mellitus is a heterogeneous group of chronic hyperglycemic disorders, considered a syndrome rather than a simple disease. Complications by diabetes are mostly associated with the chronicity of the disease and very little information exists about its early pathological processes. Animal models are considered very useful for the study of early diabetes. Wistar rats with lloxan induccced diabetes were used in a way to study the progresive effects of diabetes mellitus on the skin epithelium. Five animals were sacrificed at 7 days (Phase I) and five others at 26 days (Phase II) after the comprovation of hyperglycemic state. Animals not inyected with alloxan were used as control. Histometric and stereologic methods were used for the tissue analysis. Our results allow us to observe that nevertheless progressive thickness decrease is observed with the progress of the disease, epithelial thickness is observed decreased very early in the course of the diabetes. Our results suggest that, although diabetes is a chronic disease, and many of its complications are related to the chronicity, it is reasonable to think about ddeficiency in the capacity of acting as a barier for the skin epithelium even in early phases of the disease. Professionals must be aware about patients with high risk for diabetes developmentinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.21 n.2 20032003-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000200008en10.4067/S0717-95022003000200008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diabetes mellitus Hyperglycemia Skin Rat
spellingShingle	Diabetes mellitus Hyperglycemia Skin Rat Benetti Tanga,Marcelo Buttros,Kemli Raquel Nakao,Cristiano Chinali Komesu,Marilena PROGRESSIVE EFFECTS OF DIABETES MELLITUS ON THE SKIN EPITHELIUM OF THE RA
description	Skin serves as interface between inner aand outer environment, and acts a a mechanical barrier. Changes in its characteristics may lead to a higher pathogenicity, less defense capacity, or both. Diabetes mellitus is a heterogeneous group of chronic hyperglycemic disorders, considered a syndrome rather than a simple disease. Complications by diabetes are mostly associated with the chronicity of the disease and very little information exists about its early pathological processes. Animal models are considered very useful for the study of early diabetes. Wistar rats with lloxan induccced diabetes were used in a way to study the progresive effects of diabetes mellitus on the skin epithelium. Five animals were sacrificed at 7 days (Phase I) and five others at 26 days (Phase II) after the comprovation of hyperglycemic state. Animals not inyected with alloxan were used as control. Histometric and stereologic methods were used for the tissue analysis. Our results allow us to observe that nevertheless progressive thickness decrease is observed with the progress of the disease, epithelial thickness is observed decreased very early in the course of the diabetes. Our results suggest that, although diabetes is a chronic disease, and many of its complications are related to the chronicity, it is reasonable to think about ddeficiency in the capacity of acting as a barier for the skin epithelium even in early phases of the disease. Professionals must be aware about patients with high risk for diabetes development
author	Benetti Tanga,Marcelo Buttros,Kemli Raquel Nakao,Cristiano Chinali Komesu,Marilena
author_facet	Benetti Tanga,Marcelo Buttros,Kemli Raquel Nakao,Cristiano Chinali Komesu,Marilena
author_sort	Benetti Tanga,Marcelo
title	PROGRESSIVE EFFECTS OF DIABETES MELLITUS ON THE SKIN EPITHELIUM OF THE RA
title_short	PROGRESSIVE EFFECTS OF DIABETES MELLITUS ON THE SKIN EPITHELIUM OF THE RA
title_full	PROGRESSIVE EFFECTS OF DIABETES MELLITUS ON THE SKIN EPITHELIUM OF THE RA
title_fullStr	PROGRESSIVE EFFECTS OF DIABETES MELLITUS ON THE SKIN EPITHELIUM OF THE RA
title_full_unstemmed	PROGRESSIVE EFFECTS OF DIABETES MELLITUS ON THE SKIN EPITHELIUM OF THE RA
title_sort	progressive effects of diabetes mellitus on the skin epithelium of the ra
publisher	Sociedad Chilena de Anatomía
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000200008
work_keys_str_mv	AT benettitangamarcelo progressiveeffectsofdiabetesmellitusontheskinepitheliumofthera AT buttroskemliraquel progressiveeffectsofdiabetesmellitusontheskinepitheliumofthera AT nakaocristiano progressiveeffectsofdiabetesmellitusontheskinepitheliumofthera AT chinalikomesumarilena progressiveeffectsofdiabetesmellitusontheskinepitheliumofthera
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PROGRESSIVE EFFECTS OF DIABETES MELLITUS ON THE SKIN EPITHELIUM OF THE RA

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