MICE TESTICULAR DAMAGE ELICITED BY MALATHION

Organophosphorous pesticides are a healh problem worldwide, mostly for agroworkers, which are around 2600 millions of person in the year 2001. Little is known about male reproductive damage elicited by these chemicals. The acute effects of malathion (single intraperitoneal injection), 1/12 the LD50...

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Autores principales:	Bustos-Obregón,Eduardo, González-Hormazábal,Patricio
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2003
Materias:	Spermatogenesis Organophosphorous agropesticides Proliferation Apoptosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000200010
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spelling	oai:scielo:S0717-950220030002000102005-09-13MICE TESTICULAR DAMAGE ELICITED BY MALATHIONBustos-Obregón,EduardoGonzález-Hormazábal,Patricio Spermatogenesis Organophosphorous agropesticides Proliferation Apoptosis Organophosphorous pesticides are a healh problem worldwide, mostly for agroworkers, which are around 2600 millions of person in the year 2001. Little is known about male reproductive damage elicited by these chemicals. The acute effects of malathion (single intraperitoneal injection), 1/12 the LD50 to mice were analyzed at 1, 8, 16, 35 and 40 days after injection, in terms of spermatogenic cell proliferation and apoptosis and of Sertoli cell compromise as revealed by immunocytochemical detection of CK-18 (cytokeratin). The micronuclei test was done to assess for genotoxic activity of the agropesticide. The results showed decreased germ cell number followed by compensatory spermatogonial proliferation by 16 days (as shown by thymidine-H3 testicular uptake), increased apoptotic rate, mainly of spermatogonia, and preleptotene spermatocytes. Sertoli cell reactivity to CK-18, denoting alteration of them, probably due to germ cell damage, was seen in treated mice. Genotoxicity for somatic cells was demonstrated by the micronuclei test. Therefore, it is assumed that Sertoli as well as Leydig cells are affected together with spermatogenesis; recuperation of testicular morphology is seen by longer time intervalsinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.21 n.2 20032003-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000200010en10.4067/S0717-95022003000200010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Spermatogenesis Organophosphorous agropesticides Proliferation Apoptosis
spellingShingle	Spermatogenesis Organophosphorous agropesticides Proliferation Apoptosis Bustos-Obregón,Eduardo González-Hormazábal,Patricio MICE TESTICULAR DAMAGE ELICITED BY MALATHION
description	Organophosphorous pesticides are a healh problem worldwide, mostly for agroworkers, which are around 2600 millions of person in the year 2001. Little is known about male reproductive damage elicited by these chemicals. The acute effects of malathion (single intraperitoneal injection), 1/12 the LD50 to mice were analyzed at 1, 8, 16, 35 and 40 days after injection, in terms of spermatogenic cell proliferation and apoptosis and of Sertoli cell compromise as revealed by immunocytochemical detection of CK-18 (cytokeratin). The micronuclei test was done to assess for genotoxic activity of the agropesticide. The results showed decreased germ cell number followed by compensatory spermatogonial proliferation by 16 days (as shown by thymidine-H3 testicular uptake), increased apoptotic rate, mainly of spermatogonia, and preleptotene spermatocytes. Sertoli cell reactivity to CK-18, denoting alteration of them, probably due to germ cell damage, was seen in treated mice. Genotoxicity for somatic cells was demonstrated by the micronuclei test. Therefore, it is assumed that Sertoli as well as Leydig cells are affected together with spermatogenesis; recuperation of testicular morphology is seen by longer time intervals
author	Bustos-Obregón,Eduardo González-Hormazábal,Patricio
author_facet	Bustos-Obregón,Eduardo González-Hormazábal,Patricio
author_sort	Bustos-Obregón,Eduardo
title	MICE TESTICULAR DAMAGE ELICITED BY MALATHION
title_short	MICE TESTICULAR DAMAGE ELICITED BY MALATHION
title_full	MICE TESTICULAR DAMAGE ELICITED BY MALATHION
title_fullStr	MICE TESTICULAR DAMAGE ELICITED BY MALATHION
title_full_unstemmed	MICE TESTICULAR DAMAGE ELICITED BY MALATHION
title_sort	mice testicular damage elicited by malathion
publisher	Sociedad Chilena de Anatomía
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000200010
work_keys_str_mv	AT bustosobregoneduardo micetesticulardamageelicitedbymalathion AT gonzalezhormazabalpatricio micetesticulardamageelicitedbymalathion
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MICE TESTICULAR DAMAGE ELICITED BY MALATHION

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