ENVIRONMENTAL ENRICHMENT DURING EARLY POSTNATAL DEVELOPMENT DECREASES PARVALBUMIN EXPRESSION IN THE RAT SOMATOSENSORY CORTEX

In the rat brain, parvalbumin (PV) expression starts on postnatal day 8 and comprises a heterogeneous population of nonpyramidal GABAergic neurons. In the present work, an immunohistochemical study was done on control and experimental rats submitted to enriched environmental conditions between postn...

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Autores principales:	Inzunza,Oscar, Bravo,Hermes, Fernández,Víctor
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2003
Materias:	Neuropeptide PV Cerebral cortex Polysensorial stimulation Rodents Immunohistochemistry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000300001
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spelling	oai:scielo:S0717-950220030003000012003-11-28ENVIRONMENTAL ENRICHMENT DURING EARLY POSTNATAL DEVELOPMENT DECREASES PARVALBUMIN EXPRESSION IN THE RAT SOMATOSENSORY CORTEXInzunza,OscarBravo,HermesFernández,Víctor Neuropeptide PV Cerebral cortex Polysensorial stimulation Rodents Immunohistochemistry In the rat brain, parvalbumin (PV) expression starts on postnatal day 8 and comprises a heterogeneous population of nonpyramidal GABAergic neurons. In the present work, an immunohistochemical study was done on control and experimental rats submitted to enriched environmental conditions between postnatal days 3 to 18 or 3 to 24. Counts of PV+ neurons were made in the dorsomedial and in the ventrolateral regions of the somatosensory cortex. In control animals, PV+ neurons reached a peak on day 24 declining towards day 120. In these rats a peculiar distribution pattern was detected in which immunoreactive neurons are more numerous in the dorsomedial than ventrolateral regions as well in infragranular than supragranular layers and in posterior regions than anterior ones. Differences observed in these three dimensions were well established on day 24. Rats exposed to the enriched environment from day 3 to day 24 show a reduction (26%) in the number of PV+ neurons. The effects of the enrichment persisted for at least 12 days since animals submitted to the enriched condition from day 3 to day 18 and sacrificed on day 30 present a similar reduction (29%) in the number of PV immunoreactive neurons. Environmental enrichment induces a significant reduction of PV+ neurons but the overall distribution is retained. This finding suggests some degree of stability in the expression of PV in the rat somatosensory cortexinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.21 n.3 20032003-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000300001en10.4067/S0717-95022003000300001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Neuropeptide PV Cerebral cortex Polysensorial stimulation Rodents Immunohistochemistry
spellingShingle	Neuropeptide PV Cerebral cortex Polysensorial stimulation Rodents Immunohistochemistry Inzunza,Oscar Bravo,Hermes Fernández,Víctor ENVIRONMENTAL ENRICHMENT DURING EARLY POSTNATAL DEVELOPMENT DECREASES PARVALBUMIN EXPRESSION IN THE RAT SOMATOSENSORY CORTEX
description	In the rat brain, parvalbumin (PV) expression starts on postnatal day 8 and comprises a heterogeneous population of nonpyramidal GABAergic neurons. In the present work, an immunohistochemical study was done on control and experimental rats submitted to enriched environmental conditions between postnatal days 3 to 18 or 3 to 24. Counts of PV+ neurons were made in the dorsomedial and in the ventrolateral regions of the somatosensory cortex. In control animals, PV+ neurons reached a peak on day 24 declining towards day 120. In these rats a peculiar distribution pattern was detected in which immunoreactive neurons are more numerous in the dorsomedial than ventrolateral regions as well in infragranular than supragranular layers and in posterior regions than anterior ones. Differences observed in these three dimensions were well established on day 24. Rats exposed to the enriched environment from day 3 to day 24 show a reduction (26%) in the number of PV+ neurons. The effects of the enrichment persisted for at least 12 days since animals submitted to the enriched condition from day 3 to day 18 and sacrificed on day 30 present a similar reduction (29%) in the number of PV immunoreactive neurons. Environmental enrichment induces a significant reduction of PV+ neurons but the overall distribution is retained. This finding suggests some degree of stability in the expression of PV in the rat somatosensory cortex
author	Inzunza,Oscar Bravo,Hermes Fernández,Víctor
author_facet	Inzunza,Oscar Bravo,Hermes Fernández,Víctor
author_sort	Inzunza,Oscar
title	ENVIRONMENTAL ENRICHMENT DURING EARLY POSTNATAL DEVELOPMENT DECREASES PARVALBUMIN EXPRESSION IN THE RAT SOMATOSENSORY CORTEX
title_short	ENVIRONMENTAL ENRICHMENT DURING EARLY POSTNATAL DEVELOPMENT DECREASES PARVALBUMIN EXPRESSION IN THE RAT SOMATOSENSORY CORTEX
title_full	ENVIRONMENTAL ENRICHMENT DURING EARLY POSTNATAL DEVELOPMENT DECREASES PARVALBUMIN EXPRESSION IN THE RAT SOMATOSENSORY CORTEX
title_fullStr	ENVIRONMENTAL ENRICHMENT DURING EARLY POSTNATAL DEVELOPMENT DECREASES PARVALBUMIN EXPRESSION IN THE RAT SOMATOSENSORY CORTEX
title_full_unstemmed	ENVIRONMENTAL ENRICHMENT DURING EARLY POSTNATAL DEVELOPMENT DECREASES PARVALBUMIN EXPRESSION IN THE RAT SOMATOSENSORY CORTEX
title_sort	environmental enrichment during early postnatal development decreases parvalbumin expression in the rat somatosensory cortex
publisher	Sociedad Chilena de Anatomía
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000300001
work_keys_str_mv	AT inzunzaoscar environmentalenrichmentduringearlypostnataldevelopmentdecreasesparvalbuminexpressionintheratsomatosensorycortex AT bravohermes environmentalenrichmentduringearlypostnataldevelopmentdecreasesparvalbuminexpressionintheratsomatosensorycortex AT fernandezvictor environmentalenrichmentduringearlypostnataldevelopmentdecreasesparvalbuminexpressionintheratsomatosensorycortex
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ENVIRONMENTAL ENRICHMENT DURING EARLY POSTNATAL DEVELOPMENT DECREASES PARVALBUMIN EXPRESSION IN THE RAT SOMATOSENSORY CORTEX

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