EFFECTS OF SODIUM CYCLAMATE IN KIDNEYS OF RATS FETUSES: A MORPHOMETRIC STUDY

The cyclamate is used as artificial non-caloric sweetner in a wide variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. It appears in the composition of the products as sodium and calcium cyclamates and cyclamic acid. The purpose of this resea...

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Autores principales:	Ferraz de Arruda,José Germano, Tadeu Martins,Alex, Pereira Godoy,José Maria, Fácio Jr,Fernando Nestor, Azoubel,Reinaldo
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2004
Materias:	Kidney Sodium cyclamate Morphometry Experimental study
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200005
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spelling	oai:scielo:S0717-950220040002000052004-09-01EFFECTS OF SODIUM CYCLAMATE IN KIDNEYS OF RATS FETUSES: A MORPHOMETRIC STUDYFerraz de Arruda,José GermanoTadeu Martins,AlexPereira Godoy,José MariaFácio Jr,Fernando NestorAzoubel,Reinaldo Kidney Sodium cyclamate Morphometry Experimental study The cyclamate is used as artificial non-caloric sweetner in a wide variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. It appears in the composition of the products as sodium and calcium cyclamates and cyclamic acid. The purpose of this research was to assess the effect of sodium cyclamate in kidneys of rats fetuses considering morphometric changes of glomerulus, proximal and distal convoluted tubules, and collecting duct. Ten pregnant rat (Rattus norvegicus) weighting an average of 238 g were divided into two groups: 5 in the control group and 5 in treated group with sodium cyclamate. Between the 10th and the 14th pregnancy day, 5 rats received an intraperitoneal daily injection of 60 mg/kg of body weight of sodium cyclamate during 5 days. At the 20th, the animals were sacrificed and the fetuses were fixed in Alfac solution, included in paraffin, sectioned and stained with haematoxyline and eosine. Morphometry by the karyometric technique was the method used. The principal measurements were glomerular volume and cell nuclei size of proximal and distal convoluted tubules and collecting duct. There were a significant decrease in fetal and placentae weight in treated group with sodium cyclamate (p = 0.004) when compared with control group. In the glomerular volume and cell nuclei size of proximal and distal convoluted tubules and collecting duct of kidneys of rats fetuses treated with sodium cyclamate, the increase was statistically significant. The results showed that the use of sodium cyclamate was effective in the reduction of fetal and placentae weight, and lenght of umbilical cords. There was a significant increase in glomerular volume and in cell nuclei size of proximal and distal convoluted tubules and collecting duct, suggesting nephrotoxicityinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.22 n.2 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200005en10.4067/S0717-95022004000200005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Kidney Sodium cyclamate Morphometry Experimental study
spellingShingle	Kidney Sodium cyclamate Morphometry Experimental study Ferraz de Arruda,José Germano Tadeu Martins,Alex Pereira Godoy,José Maria Fácio Jr,Fernando Nestor Azoubel,Reinaldo EFFECTS OF SODIUM CYCLAMATE IN KIDNEYS OF RATS FETUSES: A MORPHOMETRIC STUDY
description	The cyclamate is used as artificial non-caloric sweetner in a wide variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. It appears in the composition of the products as sodium and calcium cyclamates and cyclamic acid. The purpose of this research was to assess the effect of sodium cyclamate in kidneys of rats fetuses considering morphometric changes of glomerulus, proximal and distal convoluted tubules, and collecting duct. Ten pregnant rat (Rattus norvegicus) weighting an average of 238 g were divided into two groups: 5 in the control group and 5 in treated group with sodium cyclamate. Between the 10th and the 14th pregnancy day, 5 rats received an intraperitoneal daily injection of 60 mg/kg of body weight of sodium cyclamate during 5 days. At the 20th, the animals were sacrificed and the fetuses were fixed in Alfac solution, included in paraffin, sectioned and stained with haematoxyline and eosine. Morphometry by the karyometric technique was the method used. The principal measurements were glomerular volume and cell nuclei size of proximal and distal convoluted tubules and collecting duct. There were a significant decrease in fetal and placentae weight in treated group with sodium cyclamate (p = 0.004) when compared with control group. In the glomerular volume and cell nuclei size of proximal and distal convoluted tubules and collecting duct of kidneys of rats fetuses treated with sodium cyclamate, the increase was statistically significant. The results showed that the use of sodium cyclamate was effective in the reduction of fetal and placentae weight, and lenght of umbilical cords. There was a significant increase in glomerular volume and in cell nuclei size of proximal and distal convoluted tubules and collecting duct, suggesting nephrotoxicity
author	Ferraz de Arruda,José Germano Tadeu Martins,Alex Pereira Godoy,José Maria Fácio Jr,Fernando Nestor Azoubel,Reinaldo
author_facet	Ferraz de Arruda,José Germano Tadeu Martins,Alex Pereira Godoy,José Maria Fácio Jr,Fernando Nestor Azoubel,Reinaldo
author_sort	Ferraz de Arruda,José Germano
title	EFFECTS OF SODIUM CYCLAMATE IN KIDNEYS OF RATS FETUSES: A MORPHOMETRIC STUDY
title_short	EFFECTS OF SODIUM CYCLAMATE IN KIDNEYS OF RATS FETUSES: A MORPHOMETRIC STUDY
title_full	EFFECTS OF SODIUM CYCLAMATE IN KIDNEYS OF RATS FETUSES: A MORPHOMETRIC STUDY
title_fullStr	EFFECTS OF SODIUM CYCLAMATE IN KIDNEYS OF RATS FETUSES: A MORPHOMETRIC STUDY
title_full_unstemmed	EFFECTS OF SODIUM CYCLAMATE IN KIDNEYS OF RATS FETUSES: A MORPHOMETRIC STUDY
title_sort	effects of sodium cyclamate in kidneys of rats fetuses: a morphometric study
publisher	Sociedad Chilena de Anatomía
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200005
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EFFECTS OF SODIUM CYCLAMATE IN KIDNEYS OF RATS FETUSES: A MORPHOMETRIC STUDY

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