MORPHOLOGICAL AND MORPHOMETRIC ALTERATIONS INDUCED BY VALPROIC ACID ON RAT FETUSES' MECKEL'S CARTILAGE, LINGUAL MUSCULATURE, AND SUBMANDIBULAR GLAND

Valproic acid, an antiepileptic drug, is a well-known teratogenic agent; its main target organ is the neural tube, though organ malformations have also been described. The aim of the present work was to analyze the effects of valproic acid on embryo/fetal oral structures: Meckel's cartilage, mu...

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Autores principales:	Siéssere,Selma, Semprini,Marisa, Lopes,Ruberval A, Sala,Miguel A, Mattos,Maria G. C
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2004
Materias:	Valproic acid Rat Meckel's cartilage Lingual musculature Submandibular gland
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200006
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spelling	oai:scielo:S0717-950220040002000062004-09-01MORPHOLOGICAL AND MORPHOMETRIC ALTERATIONS INDUCED BY VALPROIC ACID ON RAT FETUSES' MECKEL'S CARTILAGE, LINGUAL MUSCULATURE, AND SUBMANDIBULAR GLANDSiéssere,SelmaSemprini,MarisaLopes,Ruberval ASala,Miguel AMattos,Maria G. C Valproic acid Rat Meckel's cartilage Lingual musculature Submandibular gland Valproic acid, an antiepileptic drug, is a well-known teratogenic agent; its main target organ is the neural tube, though organ malformations have also been described. The aim of the present work was to analyze the effects of valproic acid on embryo/fetal oral structures: Meckel's cartilage, muscles of the tongue, and submandibular gland. Rats received a intraperitoneal injected of Valproic acid (300mg/Kg) on the 10th day of their gestation. Females were sacrificed on day 20 post coitus, and fetuses were examined. No gross malformations were observed. The following morphological alterations were observed: lower body and placental weight; shorter umbilical cord length; submandibular gland parenchyma less differentiated with larger cellular cord and terminal buds, and increased nuclear volume; lingual muscles fibers disorganized and of smaller size, and smaller nuclear volume; rudimentary Meckel's cartilage with small chondrocytes and more abundant matrix. These data suggest that alterations in oral tissue, induced by valproic acid, result from a direct effect of the drug on tissues causing a delayed differentiationinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.22 n.2 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200006en10.4067/S0717-95022004000200006
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Valproic acid Rat Meckel's cartilage Lingual musculature Submandibular gland
spellingShingle	Valproic acid Rat Meckel's cartilage Lingual musculature Submandibular gland Siéssere,Selma Semprini,Marisa Lopes,Ruberval A Sala,Miguel A Mattos,Maria G. C MORPHOLOGICAL AND MORPHOMETRIC ALTERATIONS INDUCED BY VALPROIC ACID ON RAT FETUSES' MECKEL'S CARTILAGE, LINGUAL MUSCULATURE, AND SUBMANDIBULAR GLAND
description	Valproic acid, an antiepileptic drug, is a well-known teratogenic agent; its main target organ is the neural tube, though organ malformations have also been described. The aim of the present work was to analyze the effects of valproic acid on embryo/fetal oral structures: Meckel's cartilage, muscles of the tongue, and submandibular gland. Rats received a intraperitoneal injected of Valproic acid (300mg/Kg) on the 10th day of their gestation. Females were sacrificed on day 20 post coitus, and fetuses were examined. No gross malformations were observed. The following morphological alterations were observed: lower body and placental weight; shorter umbilical cord length; submandibular gland parenchyma less differentiated with larger cellular cord and terminal buds, and increased nuclear volume; lingual muscles fibers disorganized and of smaller size, and smaller nuclear volume; rudimentary Meckel's cartilage with small chondrocytes and more abundant matrix. These data suggest that alterations in oral tissue, induced by valproic acid, result from a direct effect of the drug on tissues causing a delayed differentiation
author	Siéssere,Selma Semprini,Marisa Lopes,Ruberval A Sala,Miguel A Mattos,Maria G. C
author_facet	Siéssere,Selma Semprini,Marisa Lopes,Ruberval A Sala,Miguel A Mattos,Maria G. C
author_sort	Siéssere,Selma
title	MORPHOLOGICAL AND MORPHOMETRIC ALTERATIONS INDUCED BY VALPROIC ACID ON RAT FETUSES' MECKEL'S CARTILAGE, LINGUAL MUSCULATURE, AND SUBMANDIBULAR GLAND
title_short	MORPHOLOGICAL AND MORPHOMETRIC ALTERATIONS INDUCED BY VALPROIC ACID ON RAT FETUSES' MECKEL'S CARTILAGE, LINGUAL MUSCULATURE, AND SUBMANDIBULAR GLAND
title_full	MORPHOLOGICAL AND MORPHOMETRIC ALTERATIONS INDUCED BY VALPROIC ACID ON RAT FETUSES' MECKEL'S CARTILAGE, LINGUAL MUSCULATURE, AND SUBMANDIBULAR GLAND
title_fullStr	MORPHOLOGICAL AND MORPHOMETRIC ALTERATIONS INDUCED BY VALPROIC ACID ON RAT FETUSES' MECKEL'S CARTILAGE, LINGUAL MUSCULATURE, AND SUBMANDIBULAR GLAND
title_full_unstemmed	MORPHOLOGICAL AND MORPHOMETRIC ALTERATIONS INDUCED BY VALPROIC ACID ON RAT FETUSES' MECKEL'S CARTILAGE, LINGUAL MUSCULATURE, AND SUBMANDIBULAR GLAND
title_sort	morphological and morphometric alterations induced by valproic acid on rat fetuses' meckel's cartilage, lingual musculature, and submandibular gland
publisher	Sociedad Chilena de Anatomía
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200006
work_keys_str_mv	AT siessereselma morphologicalandmorphometricalterationsinducedbyvalproicacidonratfetusesmeckelscartilagelingualmusculatureandsubmandibulargland AT semprinimarisa morphologicalandmorphometricalterationsinducedbyvalproicacidonratfetusesmeckelscartilagelingualmusculatureandsubmandibulargland AT lopesrubervala morphologicalandmorphometricalterationsinducedbyvalproicacidonratfetusesmeckelscartilagelingualmusculatureandsubmandibulargland AT salamiguela morphologicalandmorphometricalterationsinducedbyvalproicacidonratfetusesmeckelscartilagelingualmusculatureandsubmandibulargland AT mattosmariagc morphologicalandmorphometricalterationsinducedbyvalproicacidonratfetusesmeckelscartilagelingualmusculatureandsubmandibulargland
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MORPHOLOGICAL AND MORPHOMETRIC ALTERATIONS INDUCED BY VALPROIC ACID ON RAT FETUSES' MECKEL'S CARTILAGE, LINGUAL MUSCULATURE, AND SUBMANDIBULAR GLAND

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