PHENYTOIN ACTION IN THE LINGUAL MUCOSA OF RAT FETUSES: MORPHOMETRIC STUDY

Phenytoin (diphenylhydantoin, dilantin) has been the chosen anti-convulsive for the treatment of sudden disorders since the late 1930's. Several epidemiological and clinical studies in human beings showed an increase in malformations in descendants of which mothers took phenytoin during gestati...

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Autores principales:	Siéssere,Selma, Semprini,Marisa, Lopes,Ruberval A, Azoubel,Reinaldo, Sala,Miguel A, Mattos,Maria G. C, Hallak Regalo,Simone Cecílio
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2004
Materias:	Phenytoin Lingual mucosa Rat Morphometry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200009
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spelling	oai:scielo:S0717-950220040002000092004-09-01PHENYTOIN ACTION IN THE LINGUAL MUCOSA OF RAT FETUSES: MORPHOMETRIC STUDYSiéssere,SelmaSemprini,MarisaLopes,Ruberval AAzoubel,ReinaldoSala,Miguel AMattos,Maria G. CHallak Regalo,Simone Cecílio Phenytoin Lingual mucosa Rat Morphometry Phenytoin (diphenylhydantoin, dilantin) has been the chosen anti-convulsive for the treatment of sudden disorders since the late 1930's. Several epidemiological and clinical studies in human beings showed an increase in malformations in descendants of which mothers took phenytoin during gestation, such as cranio-facial development and growth abnormalities, distal phalangeal hypoplasia, and light or moderate mental deficiency. This work had the goal to study the lingual mucosa, under histopathological and morphometric standpoints, in rat fetuses which were given an intraperitonial injection, consisting of a unique dose of phenytoin (70 milligrams/kilogram of their weight). Being that, we included the examined material in paraffin, 6 micrometers thick, and also colored these incisions using hematoxylin and eosin. The morphometric parameters were estimated using drawings (50 sketches) made on paper and then measured using a millimetric scale, obtained with the aid of a light camera JENA, with final magnification 1000X. The statistical confrontation was performed employing Mann-Whitney non-parametric test. The results showed that the average body weight of treated animals decreased. Histopathological and morphometric changes at all lingual regions were observedinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.22 n.2 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200009en10.4067/S0717-95022004000200009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Phenytoin Lingual mucosa Rat Morphometry
spellingShingle	Phenytoin Lingual mucosa Rat Morphometry Siéssere,Selma Semprini,Marisa Lopes,Ruberval A Azoubel,Reinaldo Sala,Miguel A Mattos,Maria G. C Hallak Regalo,Simone Cecílio PHENYTOIN ACTION IN THE LINGUAL MUCOSA OF RAT FETUSES: MORPHOMETRIC STUDY
description	Phenytoin (diphenylhydantoin, dilantin) has been the chosen anti-convulsive for the treatment of sudden disorders since the late 1930's. Several epidemiological and clinical studies in human beings showed an increase in malformations in descendants of which mothers took phenytoin during gestation, such as cranio-facial development and growth abnormalities, distal phalangeal hypoplasia, and light or moderate mental deficiency. This work had the goal to study the lingual mucosa, under histopathological and morphometric standpoints, in rat fetuses which were given an intraperitonial injection, consisting of a unique dose of phenytoin (70 milligrams/kilogram of their weight). Being that, we included the examined material in paraffin, 6 micrometers thick, and also colored these incisions using hematoxylin and eosin. The morphometric parameters were estimated using drawings (50 sketches) made on paper and then measured using a millimetric scale, obtained with the aid of a light camera JENA, with final magnification 1000X. The statistical confrontation was performed employing Mann-Whitney non-parametric test. The results showed that the average body weight of treated animals decreased. Histopathological and morphometric changes at all lingual regions were observed
author	Siéssere,Selma Semprini,Marisa Lopes,Ruberval A Azoubel,Reinaldo Sala,Miguel A Mattos,Maria G. C Hallak Regalo,Simone Cecílio
author_facet	Siéssere,Selma Semprini,Marisa Lopes,Ruberval A Azoubel,Reinaldo Sala,Miguel A Mattos,Maria G. C Hallak Regalo,Simone Cecílio
author_sort	Siéssere,Selma
title	PHENYTOIN ACTION IN THE LINGUAL MUCOSA OF RAT FETUSES: MORPHOMETRIC STUDY
title_short	PHENYTOIN ACTION IN THE LINGUAL MUCOSA OF RAT FETUSES: MORPHOMETRIC STUDY
title_full	PHENYTOIN ACTION IN THE LINGUAL MUCOSA OF RAT FETUSES: MORPHOMETRIC STUDY
title_fullStr	PHENYTOIN ACTION IN THE LINGUAL MUCOSA OF RAT FETUSES: MORPHOMETRIC STUDY
title_full_unstemmed	PHENYTOIN ACTION IN THE LINGUAL MUCOSA OF RAT FETUSES: MORPHOMETRIC STUDY
title_sort	phenytoin action in the lingual mucosa of rat fetuses: morphometric study
publisher	Sociedad Chilena de Anatomía
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200009
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PHENYTOIN ACTION IN THE LINGUAL MUCOSA OF RAT FETUSES: MORPHOMETRIC STUDY

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