RENAL MORPHOMETRY OF FETUSES RATS TREATED WITH CADMIUM

Cadmium is a heavy metal which is found in the soil, air and food. It is present in everyday life and currently it is being implicated as a toxic, teratogenic and carcinogenic agent. It causes lesions to several organs of humans and animals alike. This work aims to investigate the toxic effects on f...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Roman,T. R. N., de Lima,E. G., Azoubel,R, Batigália,F
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2004
Materias:	Cadmium Nephrotoxicity Karyometry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000300010
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022004000300010
record_format	dspace
spelling	oai:scielo:S0717-950220040003000102004-10-26RENAL MORPHOMETRY OF FETUSES RATS TREATED WITH CADMIUMRoman,T. R. N.de Lima,E. G.Azoubel,RBatigália,F Cadmium Nephrotoxicity Karyometry Cadmium is a heavy metal which is found in the soil, air and food. It is present in everyday life and currently it is being implicated as a toxic, teratogenic and carcinogenic agent. It causes lesions to several organs of humans and animals alike. This work aims to investigate the toxic effects on fetuses of dams exposed to cadmium chloride treatment. Ten pregnant rats were divided into two groups. Five rats, the study group, received an intraperitoneal administration of cadmium chloride at 5 mg/Kg body weight on the 10th day of pregnancy and the other five, the study group, received a solution of 0.85% sodium chloride at the same dose and at the same application site. The fetuses together with the placentas and umbilical cords were collected on the 20th day of pregnancy. The administration of cadmium chloride caused a significant reduction in the sizes of both the fetuses and the placenta. The lengths of the umbilical cords were also shorter in animals of the study group when compared with the control group. This study also evaluated the morphological alterations caused in the proximal and distal convoluted renal tubules and collectors as well as the renal glomerular cells. Morphometry evidenced significant alterations in the proximal tubules and the glomerular cells and to a lesser degree in the distal tubules. The brush-border membrane cells were seen to be very sensitive and displayed some alterations. The glomeruli presented with edema and the Bowman's capsules were also affectedinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.22 n.3 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000300010en10.4067/S0717-95022004000300010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cadmium Nephrotoxicity Karyometry
spellingShingle	Cadmium Nephrotoxicity Karyometry Roman,T. R. N. de Lima,E. G. Azoubel,R Batigália,F RENAL MORPHOMETRY OF FETUSES RATS TREATED WITH CADMIUM
description	Cadmium is a heavy metal which is found in the soil, air and food. It is present in everyday life and currently it is being implicated as a toxic, teratogenic and carcinogenic agent. It causes lesions to several organs of humans and animals alike. This work aims to investigate the toxic effects on fetuses of dams exposed to cadmium chloride treatment. Ten pregnant rats were divided into two groups. Five rats, the study group, received an intraperitoneal administration of cadmium chloride at 5 mg/Kg body weight on the 10th day of pregnancy and the other five, the study group, received a solution of 0.85% sodium chloride at the same dose and at the same application site. The fetuses together with the placentas and umbilical cords were collected on the 20th day of pregnancy. The administration of cadmium chloride caused a significant reduction in the sizes of both the fetuses and the placenta. The lengths of the umbilical cords were also shorter in animals of the study group when compared with the control group. This study also evaluated the morphological alterations caused in the proximal and distal convoluted renal tubules and collectors as well as the renal glomerular cells. Morphometry evidenced significant alterations in the proximal tubules and the glomerular cells and to a lesser degree in the distal tubules. The brush-border membrane cells were seen to be very sensitive and displayed some alterations. The glomeruli presented with edema and the Bowman's capsules were also affected
author	Roman,T. R. N. de Lima,E. G. Azoubel,R Batigália,F
author_facet	Roman,T. R. N. de Lima,E. G. Azoubel,R Batigália,F
author_sort	Roman,T. R. N.
title	RENAL MORPHOMETRY OF FETUSES RATS TREATED WITH CADMIUM
title_short	RENAL MORPHOMETRY OF FETUSES RATS TREATED WITH CADMIUM
title_full	RENAL MORPHOMETRY OF FETUSES RATS TREATED WITH CADMIUM
title_fullStr	RENAL MORPHOMETRY OF FETUSES RATS TREATED WITH CADMIUM
title_full_unstemmed	RENAL MORPHOMETRY OF FETUSES RATS TREATED WITH CADMIUM
title_sort	renal morphometry of fetuses rats treated with cadmium
publisher	Sociedad Chilena de Anatomía
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000300010
work_keys_str_mv	AT romantrn renalmorphometryoffetusesratstreatedwithcadmium AT delimaeg renalmorphometryoffetusesratstreatedwithcadmium AT azoubelr renalmorphometryoffetusesratstreatedwithcadmium AT batigaliaf renalmorphometryoffetusesratstreatedwithcadmium
_version_	1718444558678753280

RENAL MORPHOMETRY OF FETUSES RATS TREATED WITH CADMIUM

Ejemplares similares