EFFECT OF CADMIUM ON RAT MAXILLARY MOLAR JUNCTIONAL EPITHELIUM DURING LACTATION: EFECTO DEL CADMIO SOBRE EL EPITELIO DE LA ZONA DE UNIÓN MAXILO-MOLAR DE RATAS DURANTE LA LACTANCIA

EFFECT OF CADMIUM ON RAT MAXILLARY MOLAR JUNCTIONAL EPITHELIUM DURING LACTATION: EFECTO DEL CADMIO SOBRE EL EPITELIO DE LA ZONA DE UNIÓN MAXILO-MOLAR DE RATAS DURANTE LA LACTANCIA

Cadmium in the air, drinking water and food has the potential to affect the health of people, mainly those who live in highly industrialized regions. Cadmium affects placental functions, can cross the placental barrier and directly disturbs fetal development. It is also excreted into milk. The organ...

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Autores principales: Ribas,Paulo, Lopes,Ruberval A., Sala,Miguel A., Ribas,Lucia M.R., de Mattos,Maria da Glória C., Semprini,Marisa, Watanabe,Ii-Sei, Regalo,Simone C.H.
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2004
Materias:
Oral mucosae
Junctional epithelium
Cadmium
Lactation
Morphometry
Stereology
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000400003
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spelling oai:scielo:S0717-950220040004000032005-02-24EFFECT OF CADMIUM ON RAT MAXILLARY MOLAR JUNCTIONAL EPITHELIUM DURING LACTATION: EFECTO DEL CADMIO SOBRE EL EPITELIO DE LA ZONA DE UNIÓN MAXILO-MOLAR DE RATAS DURANTE LA LACTANCIARibas,PauloLopes,Ruberval A.Sala,Miguel A.Ribas,Lucia M.R.de Mattos,Maria da Glória C.Semprini,MarisaWatanabe,Ii-SeiRegalo,Simone C.H. Oral mucosae Junctional epithelium Cadmium Lactation Morphometry Stereology Cadmium in the air, drinking water and food has the potential to affect the health of people, mainly those who live in highly industrialized regions. Cadmium affects placental functions, can cross the placental barrier and directly disturbs fetal development. It is also excreted into milk. The organism is particularly susceptible to cadmium exposure at perinatal period. The effect on rat maxillary molar junctional epithelium a continuous exposure to drinking water containing low level of cadmium during lactation was studied. Female rats received drinking water ad libitum containing 300 mg/l CdCl2 throughout the whole lactation. Control animals received a similar volume of water without cadmium. Lactent rats (21 day-old) were killed by lethal dose of anesthetic. The heads were separated, fixed in an "alfac" solution for 24 hours; palate region was serially sectioned in frontal plane, at level of first molars. The sections, 6 µm-thick, were stained with hematoxylin and eosin. Nuclear epithelium parameters were estimated, as well as cytoplasm and cell volume, nucleus/cytoplasm ratio, numeric and surface density and epithelial thickness. Mean body weight was 34.86 g for the control group and 18.56 g for the treated group. Histologically, the epithelium was thinner, with more numerous and smaller cells. In this experiment, cadmium induced epithelial hypotrophy, indicating a direct action in oral mucosae cells, besides retarded development in pupsinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.22 n.4 20042004-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000400003en10.4067/S0717-95022004000400003
institution Scielo Chile
collection Scielo Chile
language English
topic Oral mucosae
Junctional epithelium
Cadmium
Lactation
Morphometry
Stereology
spellingShingle Oral mucosae
Junctional epithelium
Cadmium
Lactation
Morphometry
Stereology
Ribas,Paulo
Lopes,Ruberval A.
Sala,Miguel A.
Ribas,Lucia M.R.
de Mattos,Maria da Glória C.
Semprini,Marisa
Watanabe,Ii-Sei
Regalo,Simone C.H.
EFFECT OF CADMIUM ON RAT MAXILLARY MOLAR JUNCTIONAL EPITHELIUM DURING LACTATION: EFECTO DEL CADMIO SOBRE EL EPITELIO DE LA ZONA DE UNIÓN MAXILO-MOLAR DE RATAS DURANTE LA LACTANCIA
description Cadmium in the air, drinking water and food has the potential to affect the health of people, mainly those who live in highly industrialized regions. Cadmium affects placental functions, can cross the placental barrier and directly disturbs fetal development. It is also excreted into milk. The organism is particularly susceptible to cadmium exposure at perinatal period. The effect on rat maxillary molar junctional epithelium a continuous exposure to drinking water containing low level of cadmium during lactation was studied. Female rats received drinking water ad libitum containing 300 mg/l CdCl2 throughout the whole lactation. Control animals received a similar volume of water without cadmium. Lactent rats (21 day-old) were killed by lethal dose of anesthetic. The heads were separated, fixed in an "alfac" solution for 24 hours; palate region was serially sectioned in frontal plane, at level of first molars. The sections, 6 µm-thick, were stained with hematoxylin and eosin. Nuclear epithelium parameters were estimated, as well as cytoplasm and cell volume, nucleus/cytoplasm ratio, numeric and surface density and epithelial thickness. Mean body weight was 34.86 g for the control group and 18.56 g for the treated group. Histologically, the epithelium was thinner, with more numerous and smaller cells. In this experiment, cadmium induced epithelial hypotrophy, indicating a direct action in oral mucosae cells, besides retarded development in pups
author Ribas,Paulo
Lopes,Ruberval A.
Sala,Miguel A.
Ribas,Lucia M.R.
de Mattos,Maria da Glória C.
Semprini,Marisa
Watanabe,Ii-Sei
Regalo,Simone C.H.
author_facet Ribas,Paulo
Lopes,Ruberval A.
Sala,Miguel A.
Ribas,Lucia M.R.
de Mattos,Maria da Glória C.
Semprini,Marisa
Watanabe,Ii-Sei
Regalo,Simone C.H.
author_sort Ribas,Paulo
title EFFECT OF CADMIUM ON RAT MAXILLARY MOLAR JUNCTIONAL EPITHELIUM DURING LACTATION: EFECTO DEL CADMIO SOBRE EL EPITELIO DE LA ZONA DE UNIÓN MAXILO-MOLAR DE RATAS DURANTE LA LACTANCIA
title_short EFFECT OF CADMIUM ON RAT MAXILLARY MOLAR JUNCTIONAL EPITHELIUM DURING LACTATION: EFECTO DEL CADMIO SOBRE EL EPITELIO DE LA ZONA DE UNIÓN MAXILO-MOLAR DE RATAS DURANTE LA LACTANCIA
title_full EFFECT OF CADMIUM ON RAT MAXILLARY MOLAR JUNCTIONAL EPITHELIUM DURING LACTATION: EFECTO DEL CADMIO SOBRE EL EPITELIO DE LA ZONA DE UNIÓN MAXILO-MOLAR DE RATAS DURANTE LA LACTANCIA
title_fullStr EFFECT OF CADMIUM ON RAT MAXILLARY MOLAR JUNCTIONAL EPITHELIUM DURING LACTATION: EFECTO DEL CADMIO SOBRE EL EPITELIO DE LA ZONA DE UNIÓN MAXILO-MOLAR DE RATAS DURANTE LA LACTANCIA
title_full_unstemmed EFFECT OF CADMIUM ON RAT MAXILLARY MOLAR JUNCTIONAL EPITHELIUM DURING LACTATION: EFECTO DEL CADMIO SOBRE EL EPITELIO DE LA ZONA DE UNIÓN MAXILO-MOLAR DE RATAS DURANTE LA LACTANCIA
title_sort effect of cadmium on rat maxillary molar junctional epithelium during lactation: efecto del cadmio sobre el epitelio de la zona de unión maxilo-molar de ratas durante la lactancia
publisher Sociedad Chilena de Anatomía
publishDate 2004
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000400003
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