SUBLETHAL DOSES OF MALATHION ALTER MALE REPRODUCTIVE PARAMETERS OF Eisenia foetida

Malathion is an organophosphorate insecticide whose main acute poisonous effect is the inhibition of the enzyme acetylcholinesterase. This pesticide is widely used and has been reported to damage mice spermatogenesis. The objective of this work was to evaluate the toxic risk of malathion, earthworm...

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Autores principales:	Espinoza-Navarro,Omar, Bustos-Obregón,Eduardo
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2004
Materias:	Eisenia foetida Malathion Cytotoxicity Spermatozoa Reproductive organs
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000400010
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spelling	oai:scielo:S0717-950220040004000102005-02-24SUBLETHAL DOSES OF MALATHION ALTER MALE REPRODUCTIVE PARAMETERS OF Eisenia foetidaEspinoza-Navarro,OmarBustos-Obregón,Eduardo Eisenia foetida Malathion Cytotoxicity Spermatozoa Reproductive organs Malathion is an organophosphorate insecticide whose main acute poisonous effect is the inhibition of the enzyme acetylcholinesterase. This pesticide is widely used and has been reported to damage mice spermatogenesis. The objective of this work was to evaluate the toxic risk of malathion, earthworm Eisenia foetida (Annelida, Oligochaeta) like biological model was used and testicles and spermatozoa of animal controls and treaties were analyzed. Earthworms with developed clitellum were used and they were dewed with sublethal single doses of 0, 80, 150, 300 and 600mg of malathion for kilogram of soil (LD50 = 880mg/kg dry soil). Control groups were added only distilled water. Each group was analyzed 1, 5, 15 and 30 days post treatment. The results observed in treated animals indicate a significant rise of the number of spermatozoa at 1 and 5 days post treatment, followed by a sperm decrease between 15 and 30 days. Acridine orange method showed a significant increase of abnormal metachromatic spermatozoa in treated animals (red fluorescence). Testicular histology of treated animals showed tissue disorganization and vacuolization, with presence of small and hyperchromatic nuclei, indicative of possible apoptosis. It was also found that malathion caused body contraction characterized by coiled tail. Besides significant alteration in count and quality of spermatozoa were seen. Eisenia foetida is then an excellent model to monitor cytotoxic damage of organophosphate pesticidesinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.22 n.4 20042004-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000400010en10.4067/S0717-95022004000400010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Eisenia foetida Malathion Cytotoxicity Spermatozoa Reproductive organs
spellingShingle	Eisenia foetida Malathion Cytotoxicity Spermatozoa Reproductive organs Espinoza-Navarro,Omar Bustos-Obregón,Eduardo SUBLETHAL DOSES OF MALATHION ALTER MALE REPRODUCTIVE PARAMETERS OF Eisenia foetida
description	Malathion is an organophosphorate insecticide whose main acute poisonous effect is the inhibition of the enzyme acetylcholinesterase. This pesticide is widely used and has been reported to damage mice spermatogenesis. The objective of this work was to evaluate the toxic risk of malathion, earthworm Eisenia foetida (Annelida, Oligochaeta) like biological model was used and testicles and spermatozoa of animal controls and treaties were analyzed. Earthworms with developed clitellum were used and they were dewed with sublethal single doses of 0, 80, 150, 300 and 600mg of malathion for kilogram of soil (LD50 = 880mg/kg dry soil). Control groups were added only distilled water. Each group was analyzed 1, 5, 15 and 30 days post treatment. The results observed in treated animals indicate a significant rise of the number of spermatozoa at 1 and 5 days post treatment, followed by a sperm decrease between 15 and 30 days. Acridine orange method showed a significant increase of abnormal metachromatic spermatozoa in treated animals (red fluorescence). Testicular histology of treated animals showed tissue disorganization and vacuolization, with presence of small and hyperchromatic nuclei, indicative of possible apoptosis. It was also found that malathion caused body contraction characterized by coiled tail. Besides significant alteration in count and quality of spermatozoa were seen. Eisenia foetida is then an excellent model to monitor cytotoxic damage of organophosphate pesticides
author	Espinoza-Navarro,Omar Bustos-Obregón,Eduardo
author_facet	Espinoza-Navarro,Omar Bustos-Obregón,Eduardo
author_sort	Espinoza-Navarro,Omar
title	SUBLETHAL DOSES OF MALATHION ALTER MALE REPRODUCTIVE PARAMETERS OF Eisenia foetida
title_short	SUBLETHAL DOSES OF MALATHION ALTER MALE REPRODUCTIVE PARAMETERS OF Eisenia foetida
title_full	SUBLETHAL DOSES OF MALATHION ALTER MALE REPRODUCTIVE PARAMETERS OF Eisenia foetida
title_fullStr	SUBLETHAL DOSES OF MALATHION ALTER MALE REPRODUCTIVE PARAMETERS OF Eisenia foetida
title_full_unstemmed	SUBLETHAL DOSES OF MALATHION ALTER MALE REPRODUCTIVE PARAMETERS OF Eisenia foetida
title_sort	sublethal doses of malathion alter male reproductive parameters of eisenia foetida
publisher	Sociedad Chilena de Anatomía
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000400010
work_keys_str_mv	AT espinozanavarroomar sublethaldosesofmalathionaltermalereproductiveparametersofeiseniafoetida AT bustosobregoneduardo sublethaldosesofmalathionaltermalereproductiveparametersofeiseniafoetida
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SUBLETHAL DOSES OF MALATHION ALTER MALE REPRODUCTIVE PARAMETERS OF Eisenia foetida

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