Immune Cells Depletion During Wound Healing as a Long-Term Effect of Undernutrition
Undernutrition in early life is associated with a number of acute and chronic sequelae, and recovering is a controversial issue. Even if undernutrition in Brazil is declining, studies have shown that about 31% of brazilian children still present severe or moderate malnutrition. The present study goa...
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| Lenguaje: | English |
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Sociedad Chilena de Anatomía
2005
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oai:scielo:S0717-950220050001000052005-05-17Immune Cells Depletion During Wound Healing as a Long-Term Effect of UndernutritionZuanassi Macari,MarceloMisael Cavenaghi,FabianoChinali Komesu,MarilenaOrive Lunardi,LaurelúciaSala,Miguel AngelNovaes Júnior,Arthur BelémGrisi,Márcio Fernando de MoraesTaba Júnior,MárioScombatti de Souza,Sérgio Luiz Undernourishment Wound healing Defense cells Undernutrition in early life is associated with a number of acute and chronic sequelae, and recovering is a controversial issue. Even if undernutrition in Brazil is declining, studies have shown that about 31% of brazilian children still present severe or moderate malnutrition. The present study goal was to induce early malnutrition in rats and observe short- (undernourished) and long-term (after recovered) effects on defense cells involved in wound healing. Undernutrition was produced by separating the pups from the mother for 10 hours/day during the suckling period (21 days after birth). As controls were used rats at same age not submitted to suckling restriction. Undernutrition and recovering states were assessed by body weight. Skin wounds were made on the shaved backs of all, undernourished, recovered and their controls, under tribromoethanol anesthesia. Aninals were sacrificed 1, 3, 7 and 14 days after surgery and the tissues were properly prepared and observed under light microscopy. Our results showed that: 1) neutrophils, lymphocytes and macrophages couting in healing area were lower in undernourished and in recovered animals as compared with their controls; 2) there were a basal deficiency in lymphocytes and macrophages numbers in recovered animals but not in those acutelly undernourished. These results allow us to conclude that post-nattally undernourished animals submitted to a nutritional rescue time showed a complete recovery in physical weight, but in spite of the physical recovery, the wound healing showed less defense cell density in healing areas suggesting long-term sequelae of early undernutritioninfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.23 n.1 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000100005en10.4067/S0717-95022005000100005 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Undernourishment Wound healing Defense cells |
| spellingShingle |
Undernourishment Wound healing Defense cells Zuanassi Macari,Marcelo Misael Cavenaghi,Fabiano Chinali Komesu,Marilena Orive Lunardi,Laurelúcia Sala,Miguel Angel Novaes Júnior,Arthur Belém Grisi,Márcio Fernando de Moraes Taba Júnior,Mário Scombatti de Souza,Sérgio Luiz Immune Cells Depletion During Wound Healing as a Long-Term Effect of Undernutrition |
| description |
Undernutrition in early life is associated with a number of acute and chronic sequelae, and recovering is a controversial issue. Even if undernutrition in Brazil is declining, studies have shown that about 31% of brazilian children still present severe or moderate malnutrition. The present study goal was to induce early malnutrition in rats and observe short- (undernourished) and long-term (after recovered) effects on defense cells involved in wound healing. Undernutrition was produced by separating the pups from the mother for 10 hours/day during the suckling period (21 days after birth). As controls were used rats at same age not submitted to suckling restriction. Undernutrition and recovering states were assessed by body weight. Skin wounds were made on the shaved backs of all, undernourished, recovered and their controls, under tribromoethanol anesthesia. Aninals were sacrificed 1, 3, 7 and 14 days after surgery and the tissues were properly prepared and observed under light microscopy. Our results showed that: 1) neutrophils, lymphocytes and macrophages couting in healing area were lower in undernourished and in recovered animals as compared with their controls; 2) there were a basal deficiency in lymphocytes and macrophages numbers in recovered animals but not in those acutelly undernourished. These results allow us to conclude that post-nattally undernourished animals submitted to a nutritional rescue time showed a complete recovery in physical weight, but in spite of the physical recovery, the wound healing showed less defense cell density in healing areas suggesting long-term sequelae of early undernutrition |
| author |
Zuanassi Macari,Marcelo Misael Cavenaghi,Fabiano Chinali Komesu,Marilena Orive Lunardi,Laurelúcia Sala,Miguel Angel Novaes Júnior,Arthur Belém Grisi,Márcio Fernando de Moraes Taba Júnior,Mário Scombatti de Souza,Sérgio Luiz |
| author_facet |
Zuanassi Macari,Marcelo Misael Cavenaghi,Fabiano Chinali Komesu,Marilena Orive Lunardi,Laurelúcia Sala,Miguel Angel Novaes Júnior,Arthur Belém Grisi,Márcio Fernando de Moraes Taba Júnior,Mário Scombatti de Souza,Sérgio Luiz |
| author_sort |
Zuanassi Macari,Marcelo |
| title |
Immune Cells Depletion During Wound Healing as a Long-Term Effect of Undernutrition |
| title_short |
Immune Cells Depletion During Wound Healing as a Long-Term Effect of Undernutrition |
| title_full |
Immune Cells Depletion During Wound Healing as a Long-Term Effect of Undernutrition |
| title_fullStr |
Immune Cells Depletion During Wound Healing as a Long-Term Effect of Undernutrition |
| title_full_unstemmed |
Immune Cells Depletion During Wound Healing as a Long-Term Effect of Undernutrition |
| title_sort |
immune cells depletion during wound healing as a long-term effect of undernutrition |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2005 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000100005 |
| work_keys_str_mv |
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| _version_ |
1718444562926534656 |