Cyclophosphamide Effect on the Epithelial Covering of Rats Fetuse's Tongue: A Morphometric Study

The present study has the aim to describe morphologically, morphometrically and stereologically some changes in the tongue epithelium of rat fetuses under the effect of cyclosphosphamide. This drug was used in a single 6mg/kg according to the body weight in the tenth pregnancy day while the contro...

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Autores principales:	De Lucia,M. B. I., Azoubel,R.
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2005
Materias:	Cyclophosphamide Teratology Tongue
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000200002
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spelling	oai:scielo:S0717-950220050002000022005-08-25Cyclophosphamide Effect on the Epithelial Covering of Rats Fetuse's Tongue: A Morphometric StudyDe Lucia,M. B. I.Azoubel,R. Cyclophosphamide Teratology Tongue The present study has the aim to describe morphologically, morphometrically and stereologically some changes in the tongue epithelium of rat fetuses under the effect of cyclosphosphamide. This drug was used in a single 6mg/kg according to the body weight in the tenth pregnancy day while the control group received equal dosage of saline solution by the same duct and in the same day of pregnancy. The fetuses were plunged into fixed solution of Bouin for five days and the heads of then were divided and blocked in paraffin. Histological sections of six-micrometer thickness were performed and then colored with hematoxilin and eosin. It was used morphometrical and stereological analysis after the morphological study. The data were submitted under the statistical non-parametric test of Mann-Whitney. The results showed that the cyclosposphamide usage effect during the rat pregnancy caused a delayed in the embryo fetal growing, a reduction in the placental weight as wells as in the umbilicus cord length. The covering epithelia in the tongue of the treated group showed some changes since there was an epithelial hyperplasia associated with a cell hypotrophy. The fetuses in this group were more premature than the ones in the controlinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.23 n.2 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000200002en10.4067/S0717-95022005000200002
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cyclophosphamide Teratology Tongue
spellingShingle	Cyclophosphamide Teratology Tongue De Lucia,M. B. I. Azoubel,R. Cyclophosphamide Effect on the Epithelial Covering of Rats Fetuse's Tongue: A Morphometric Study
description	The present study has the aim to describe morphologically, morphometrically and stereologically some changes in the tongue epithelium of rat fetuses under the effect of cyclosphosphamide. This drug was used in a single 6mg/kg according to the body weight in the tenth pregnancy day while the control group received equal dosage of saline solution by the same duct and in the same day of pregnancy. The fetuses were plunged into fixed solution of Bouin for five days and the heads of then were divided and blocked in paraffin. Histological sections of six-micrometer thickness were performed and then colored with hematoxilin and eosin. It was used morphometrical and stereological analysis after the morphological study. The data were submitted under the statistical non-parametric test of Mann-Whitney. The results showed that the cyclosposphamide usage effect during the rat pregnancy caused a delayed in the embryo fetal growing, a reduction in the placental weight as wells as in the umbilicus cord length. The covering epithelia in the tongue of the treated group showed some changes since there was an epithelial hyperplasia associated with a cell hypotrophy. The fetuses in this group were more premature than the ones in the control
author	De Lucia,M. B. I. Azoubel,R.
author_facet	De Lucia,M. B. I. Azoubel,R.
author_sort	De Lucia,M. B. I.
title	Cyclophosphamide Effect on the Epithelial Covering of Rats Fetuse's Tongue: A Morphometric Study
title_short	Cyclophosphamide Effect on the Epithelial Covering of Rats Fetuse's Tongue: A Morphometric Study
title_full	Cyclophosphamide Effect on the Epithelial Covering of Rats Fetuse's Tongue: A Morphometric Study
title_fullStr	Cyclophosphamide Effect on the Epithelial Covering of Rats Fetuse's Tongue: A Morphometric Study
title_full_unstemmed	Cyclophosphamide Effect on the Epithelial Covering of Rats Fetuse's Tongue: A Morphometric Study
title_sort	cyclophosphamide effect on the epithelial covering of rats fetuse's tongue: a morphometric study
publisher	Sociedad Chilena de Anatomía
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000200002
work_keys_str_mv	AT deluciambi cyclophosphamideeffectontheepithelialcoveringofratsfetusestongueamorphometricstudy AT azoubelr cyclophosphamideeffectontheepithelialcoveringofratsfetusestongueamorphometricstudy
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Cyclophosphamide Effect on the Epithelial Covering of Rats Fetuse's Tongue: A Morphometric Study

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