Foscarnet Effects on the Rat Pregnancy Outcome
There are few long-term data on which to base decisions of drug management of HIV infection in pregnancy. The determination of safe medications must take into consideration the need for certain drugs and the possibility of inadvertent fetal exposure because of unplanned pregnancies. The aim of this...
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Sociedad Chilena de Anatomía
2005
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oai:scielo:S0717-950220050002000082005-08-25Foscarnet Effects on the Rat Pregnancy OutcomeVenneri Mathias,CíceroSimões,Manuel de JesusMahmed Amed,AbesMartins Oliveira-Filho,RicardoVenneri Mathias,Camila Fernandesdos Santos Simões,RicardoKulay Júnior,Luiz Antiretroviral drugs Foscarnet Pregnancy Rat There are few long-term data on which to base decisions of drug management of HIV infection in pregnancy. The determination of safe medications must take into consideration the need for certain drugs and the possibility of inadvertent fetal exposure because of unplanned pregnancies. The aim of this study was to evaluate the effects of foscarnet on the entire period of rat pregnancy. Female pregnant rats were randomly assigned to four treatment groups (n = 10): one control (C) treated with the drug vehicle (bidestilled water) and three experimental groups (E1, E2 and E3) treated with 180, 360 or 720 mg/Kg of foscarnet, respectively. Rats were treated by gavage once daily. The treatment period extended from the first until the 20th day of pregnancy. Body weights were recorded weekly along this period. At term, the rats were sacrificed, the implantation sites and the number of fetuses and resorptions were recorded. The fetuses were evaluated for externally visible abnormalities under a stereomicroscope. No differences in body weights among the groups were observed; however, foscarnet-treated rats showed reduced fetal and placental weights. The incidence 137of resorptions and major malformations (shortening of limbs) in the E3 group was significantly raised. Foscarnet treatment during the entire period of rat pregnancy can produce definite toxic effects, mainly on the placental and fetal compartmentsinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.23 n.2 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000200008en10.4067/S0717-95022005000200008 |
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Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Antiretroviral drugs Foscarnet Pregnancy Rat |
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Antiretroviral drugs Foscarnet Pregnancy Rat Venneri Mathias,Cícero Simões,Manuel de Jesus Mahmed Amed,Abes Martins Oliveira-Filho,Ricardo Venneri Mathias,Camila Fernandes dos Santos Simões,Ricardo Kulay Júnior,Luiz Foscarnet Effects on the Rat Pregnancy Outcome |
| description |
There are few long-term data on which to base decisions of drug management of HIV infection in pregnancy. The determination of safe medications must take into consideration the need for certain drugs and the possibility of inadvertent fetal exposure because of unplanned pregnancies. The aim of this study was to evaluate the effects of foscarnet on the entire period of rat pregnancy. Female pregnant rats were randomly assigned to four treatment groups (n = 10): one control (C) treated with the drug vehicle (bidestilled water) and three experimental groups (E1, E2 and E3) treated with 180, 360 or 720 mg/Kg of foscarnet, respectively. Rats were treated by gavage once daily. The treatment period extended from the first until the 20th day of pregnancy. Body weights were recorded weekly along this period. At term, the rats were sacrificed, the implantation sites and the number of fetuses and resorptions were recorded. The fetuses were evaluated for externally visible abnormalities under a stereomicroscope. No differences in body weights among the groups were observed; however, foscarnet-treated rats showed reduced fetal and placental weights. The incidence 137of resorptions and major malformations (shortening of limbs) in the E3 group was significantly raised. Foscarnet treatment during the entire period of rat pregnancy can produce definite toxic effects, mainly on the placental and fetal compartments |
| author |
Venneri Mathias,Cícero Simões,Manuel de Jesus Mahmed Amed,Abes Martins Oliveira-Filho,Ricardo Venneri Mathias,Camila Fernandes dos Santos Simões,Ricardo Kulay Júnior,Luiz |
| author_facet |
Venneri Mathias,Cícero Simões,Manuel de Jesus Mahmed Amed,Abes Martins Oliveira-Filho,Ricardo Venneri Mathias,Camila Fernandes dos Santos Simões,Ricardo Kulay Júnior,Luiz |
| author_sort |
Venneri Mathias,Cícero |
| title |
Foscarnet Effects on the Rat Pregnancy Outcome |
| title_short |
Foscarnet Effects on the Rat Pregnancy Outcome |
| title_full |
Foscarnet Effects on the Rat Pregnancy Outcome |
| title_fullStr |
Foscarnet Effects on the Rat Pregnancy Outcome |
| title_full_unstemmed |
Foscarnet Effects on the Rat Pregnancy Outcome |
| title_sort |
foscarnet effects on the rat pregnancy outcome |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2005 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000200008 |
| work_keys_str_mv |
AT vennerimathiascicero foscarneteffectsontheratpregnancyoutcome AT simoesmanueldejesus foscarneteffectsontheratpregnancyoutcome AT mahmedamedabes foscarneteffectsontheratpregnancyoutcome AT martinsoliveirafilhoricardo foscarneteffectsontheratpregnancyoutcome AT vennerimathiascamilafernandes foscarneteffectsontheratpregnancyoutcome AT dossantossimoesricardo foscarneteffectsontheratpregnancyoutcome AT kulayjuniorluiz foscarneteffectsontheratpregnancyoutcome |
| _version_ |
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