Effect of Lamivudine on the Rat Pregnancy Outcome

Human immunodeficiency virus (HIV) infection is in growing incidence throughout the world. Due to the increasing proportion of affected women in reproductive years, the association of pregnancy with HIV infection becomes a matter of major Public Health concern. Antiretroviral drug administration tur...

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Autores principales:	Pontes,Rosana Dorsa Vieira, Amed,Abês Mamed, Simões,Manuel Jesus, Oliveira-Filho,Ricardo Martins, Simões,Ricardo Santos, Kulay Jr,Luiz
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2005
Materias:	Lamivudine Toxicology Rat Pregnancy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000300001
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spelling	oai:scielo:S0717-950220050003000012005-10-28Effect of Lamivudine on the Rat Pregnancy OutcomePontes,Rosana Dorsa VieiraAmed,Abês MamedSimões,Manuel JesusOliveira-Filho,Ricardo MartinsSimões,Ricardo SantosKulay Jr,Luiz Lamivudine Toxicology Rat Pregnancy Human immunodeficiency virus (HIV) infection is in growing incidence throughout the world. Due to the increasing proportion of affected women in reproductive years, the association of pregnancy with HIV infection becomes a matter of major Public Health concern. Antiretroviral drug administration turned out to be imperative during pregnancy in order to prevent the vertical transmission; accordingly, new antiretroviral drugs and anti-HIV drug associations have been tested in experimental pregnancy models before they are approved to be included in protocols for use during human pregnancy. Lamivudine is a nucleoside reverse transcriptase inhibitor currently used in association with other antiretrovirals. Since no data exist on the perinatal safety of lamivudine alone, as it is used in combination with other antiretroviral agents, and, until now, only preliminary data on the lamivudine-zidovudine combination were available, we decided to examine the gross maternal and fetal effects of lamivudine administered alone during the entire period of rat pregnancy. Forty pregnant animals were assigned at random to 4 groups (G1, G2, G3 and G4). G1 received drug vehicle; G2, G3 and G4 received daily oral doses of 5, 15 or 45 mg/kg of lamivudine, respectively. Rats were weighed on days 0, 7, 14 and 20 of pregnancy. On day 20 they were killed, their fetuses and placentas counted and weighed. The body weight gain of the rats was that normally expected for the gestation progression; no differences were noticed among the groups. In addition, no effects were observed regarding the fetal or placental number and weight, nor in the number of implantations, reabsortions, fetal or maternal deaths. In conclusion, the adverse effects reported for the lamivudine-zidovudine combination therapy may well be not due to lamivudine; further research involving a variety of strategies is needed to definitively ascertain the safety of that combination for preventing maternal-infant HIV transmissioninfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.23 n.3 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000300001en10.4067/S0717-95022005000300001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Lamivudine Toxicology Rat Pregnancy
spellingShingle	Lamivudine Toxicology Rat Pregnancy Pontes,Rosana Dorsa Vieira Amed,Abês Mamed Simões,Manuel Jesus Oliveira-Filho,Ricardo Martins Simões,Ricardo Santos Kulay Jr,Luiz Effect of Lamivudine on the Rat Pregnancy Outcome
description	Human immunodeficiency virus (HIV) infection is in growing incidence throughout the world. Due to the increasing proportion of affected women in reproductive years, the association of pregnancy with HIV infection becomes a matter of major Public Health concern. Antiretroviral drug administration turned out to be imperative during pregnancy in order to prevent the vertical transmission; accordingly, new antiretroviral drugs and anti-HIV drug associations have been tested in experimental pregnancy models before they are approved to be included in protocols for use during human pregnancy. Lamivudine is a nucleoside reverse transcriptase inhibitor currently used in association with other antiretrovirals. Since no data exist on the perinatal safety of lamivudine alone, as it is used in combination with other antiretroviral agents, and, until now, only preliminary data on the lamivudine-zidovudine combination were available, we decided to examine the gross maternal and fetal effects of lamivudine administered alone during the entire period of rat pregnancy. Forty pregnant animals were assigned at random to 4 groups (G1, G2, G3 and G4). G1 received drug vehicle; G2, G3 and G4 received daily oral doses of 5, 15 or 45 mg/kg of lamivudine, respectively. Rats were weighed on days 0, 7, 14 and 20 of pregnancy. On day 20 they were killed, their fetuses and placentas counted and weighed. The body weight gain of the rats was that normally expected for the gestation progression; no differences were noticed among the groups. In addition, no effects were observed regarding the fetal or placental number and weight, nor in the number of implantations, reabsortions, fetal or maternal deaths. In conclusion, the adverse effects reported for the lamivudine-zidovudine combination therapy may well be not due to lamivudine; further research involving a variety of strategies is needed to definitively ascertain the safety of that combination for preventing maternal-infant HIV transmission
author	Pontes,Rosana Dorsa Vieira Amed,Abês Mamed Simões,Manuel Jesus Oliveira-Filho,Ricardo Martins Simões,Ricardo Santos Kulay Jr,Luiz
author_facet	Pontes,Rosana Dorsa Vieira Amed,Abês Mamed Simões,Manuel Jesus Oliveira-Filho,Ricardo Martins Simões,Ricardo Santos Kulay Jr,Luiz
author_sort	Pontes,Rosana Dorsa Vieira
title	Effect of Lamivudine on the Rat Pregnancy Outcome
title_short	Effect of Lamivudine on the Rat Pregnancy Outcome
title_full	Effect of Lamivudine on the Rat Pregnancy Outcome
title_fullStr	Effect of Lamivudine on the Rat Pregnancy Outcome
title_full_unstemmed	Effect of Lamivudine on the Rat Pregnancy Outcome
title_sort	effect of lamivudine on the rat pregnancy outcome
publisher	Sociedad Chilena de Anatomía
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000300001
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Effect of Lamivudine on the Rat Pregnancy Outcome

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