Effects of Sodium Cyclamate on the Rat Placenta: A Morphometric Study

To evaluate the effects of sodium cyclamate on the rat placenta by its administration in the period of embryogenesis. The sodium cyclamate was administered by intraperitoneal route in rats of the treated group at the dose of 60 mg/Kg, from the tenth to fourteenth day of gestation, while the equivale...

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Autores principales:	de Matos,Marcelo Alexandre, Martins,Alex Tadeu, Azoubel,Reinaldo
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2006
Materias:	Sodium cyclamate Placenta Cariometry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300001
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spelling	oai:scielo:S0717-950220060003000012006-08-28Effects of Sodium Cyclamate on the Rat Placenta: A Morphometric Studyde Matos,Marcelo AlexandreMartins,Alex TadeuAzoubel,Reinaldo Sodium cyclamate Placenta Cariometry To evaluate the effects of sodium cyclamate on the rat placenta by its administration in the period of embryogenesis. The sodium cyclamate was administered by intraperitoneal route in rats of the treated group at the dose of 60 mg/Kg, from the tenth to fourteenth day of gestation, while the equivalent volume of saline solution was given to the control group, by the same route. On the twentieth day of pregnancy, 10 fetuses (5 from each group) were chosen at random for study. The technique of cariometry was utilized for evaluation of nuclear parameters of cells in deciduous and spongy layers, and of chorionic villi in the rat placenta. The weights of treated fetuses and their placentas were less than those of the control group, while umbilical-cord length in the treated group was shorter than that in control fetuses. There were no alterations in the deciduous layer. In the placental spongy layer were found alterations of the following parameters: major diameter, mean diameter, perimeter, area, volume, the volume/area ratio and eccentricity. The altered parameters in chorionic villi were the following: mean diameter, perimeter, area, volume and volume/area ratio. This study demonstrated placental alteration with the use of cyclamate by the pregnant rat, and its repercussion in fetal weight and umbilical-cord lengthinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.24 n.2 20062006-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300001en10.4067/S0717-95022006000300001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sodium cyclamate Placenta Cariometry
spellingShingle	Sodium cyclamate Placenta Cariometry de Matos,Marcelo Alexandre Martins,Alex Tadeu Azoubel,Reinaldo Effects of Sodium Cyclamate on the Rat Placenta: A Morphometric Study
description	To evaluate the effects of sodium cyclamate on the rat placenta by its administration in the period of embryogenesis. The sodium cyclamate was administered by intraperitoneal route in rats of the treated group at the dose of 60 mg/Kg, from the tenth to fourteenth day of gestation, while the equivalent volume of saline solution was given to the control group, by the same route. On the twentieth day of pregnancy, 10 fetuses (5 from each group) were chosen at random for study. The technique of cariometry was utilized for evaluation of nuclear parameters of cells in deciduous and spongy layers, and of chorionic villi in the rat placenta. The weights of treated fetuses and their placentas were less than those of the control group, while umbilical-cord length in the treated group was shorter than that in control fetuses. There were no alterations in the deciduous layer. In the placental spongy layer were found alterations of the following parameters: major diameter, mean diameter, perimeter, area, volume, the volume/area ratio and eccentricity. The altered parameters in chorionic villi were the following: mean diameter, perimeter, area, volume and volume/area ratio. This study demonstrated placental alteration with the use of cyclamate by the pregnant rat, and its repercussion in fetal weight and umbilical-cord length
author	de Matos,Marcelo Alexandre Martins,Alex Tadeu Azoubel,Reinaldo
author_facet	de Matos,Marcelo Alexandre Martins,Alex Tadeu Azoubel,Reinaldo
author_sort	de Matos,Marcelo Alexandre
title	Effects of Sodium Cyclamate on the Rat Placenta: A Morphometric Study
title_short	Effects of Sodium Cyclamate on the Rat Placenta: A Morphometric Study
title_full	Effects of Sodium Cyclamate on the Rat Placenta: A Morphometric Study
title_fullStr	Effects of Sodium Cyclamate on the Rat Placenta: A Morphometric Study
title_full_unstemmed	Effects of Sodium Cyclamate on the Rat Placenta: A Morphometric Study
title_sort	effects of sodium cyclamate on the rat placenta: a morphometric study
publisher	Sociedad Chilena de Anatomía
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300001
work_keys_str_mv	AT dematosmarceloalexandre effectsofsodiumcyclamateontheratplacentaamorphometricstudy AT martinsalextadeu effectsofsodiumcyclamateontheratplacentaamorphometricstudy AT azoubelreinaldo effectsofsodiumcyclamateontheratplacentaamorphometricstudy
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Effects of Sodium Cyclamate on the Rat Placenta: A Morphometric Study

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