Effect of Flutamide in Mouse Spermatogenesis and on the Function of Seminal Vesicle and Prostate

The spermatogenesis is regulated by the hypotalamus-hypophysis gonadal axis, and the androgens play a fundamental role in their last stages. The administration of the antiandrogen flutamide interferes with the function of androgen dependent organs (Prostate (P) and Seminal Vesicle (VS)). In this stu...

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Autores principales:	Bustos-Obregón,Eduardo, Esponda,Pedro, Sarabia,Luis
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2006
Materias:	Flutamide Mouse Spermatogenesis Seminal vesicles Prostate
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300008
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spelling	oai:scielo:S0717-950220060003000082006-08-28Effect of Flutamide in Mouse Spermatogenesis and on the Function of Seminal Vesicle and ProstateBustos-Obregón,EduardoEsponda,PedroSarabia,Luis Flutamide Mouse Spermatogenesis Seminal vesicles Prostate The spermatogenesis is regulated by the hypotalamus-hypophysis gonadal axis, and the androgens play a fundamental role in their last stages. The administration of the antiandrogen flutamide interferes with the function of androgen dependent organs (Prostate (P) and Seminal Vesicle (VS)). In this study flutamide (10mg/Kg b.w.) was injected to 10 mice and vehicle to the controls (n=6). The mice were sacrificed at 24 (n=5) and 72 (n=5) hours. In testicular sections the tubular diameter (TD) and height of seminiferous epithelium (EH) were measured. P and VS were macerated, and concentrations of fructose (VS) and zinc (P) were determined. No significant difference exists in the DT among the groups. However, the 72 hrs group showed EH higher than the control (p < 0.01). The fructose is lower at 72 hrs (p < 0.01) interval, at which the biggest concentration of zinc is found (p < 0.01). The decrease of the EH could be explained by the detachment of the elongated espermatids, due to the blockade effect on the testosterone activity, without being reflected in the TD at this short interval. The decrease of fructose clearly shows the deprivacion of androgens, whereas the elevated concentration of prostatic Zn at 72 hrs suggests deficiency in the secretion of Zn to the seminal plasmainfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.24 n.2 20062006-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300008en10.4067/S0717-95022006000300008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Flutamide Mouse Spermatogenesis Seminal vesicles Prostate
spellingShingle	Flutamide Mouse Spermatogenesis Seminal vesicles Prostate Bustos-Obregón,Eduardo Esponda,Pedro Sarabia,Luis Effect of Flutamide in Mouse Spermatogenesis and on the Function of Seminal Vesicle and Prostate
description	The spermatogenesis is regulated by the hypotalamus-hypophysis gonadal axis, and the androgens play a fundamental role in their last stages. The administration of the antiandrogen flutamide interferes with the function of androgen dependent organs (Prostate (P) and Seminal Vesicle (VS)). In this study flutamide (10mg/Kg b.w.) was injected to 10 mice and vehicle to the controls (n=6). The mice were sacrificed at 24 (n=5) and 72 (n=5) hours. In testicular sections the tubular diameter (TD) and height of seminiferous epithelium (EH) were measured. P and VS were macerated, and concentrations of fructose (VS) and zinc (P) were determined. No significant difference exists in the DT among the groups. However, the 72 hrs group showed EH higher than the control (p < 0.01). The fructose is lower at 72 hrs (p < 0.01) interval, at which the biggest concentration of zinc is found (p < 0.01). The decrease of the EH could be explained by the detachment of the elongated espermatids, due to the blockade effect on the testosterone activity, without being reflected in the TD at this short interval. The decrease of fructose clearly shows the deprivacion of androgens, whereas the elevated concentration of prostatic Zn at 72 hrs suggests deficiency in the secretion of Zn to the seminal plasma
author	Bustos-Obregón,Eduardo Esponda,Pedro Sarabia,Luis
author_facet	Bustos-Obregón,Eduardo Esponda,Pedro Sarabia,Luis
author_sort	Bustos-Obregón,Eduardo
title	Effect of Flutamide in Mouse Spermatogenesis and on the Function of Seminal Vesicle and Prostate
title_short	Effect of Flutamide in Mouse Spermatogenesis and on the Function of Seminal Vesicle and Prostate
title_full	Effect of Flutamide in Mouse Spermatogenesis and on the Function of Seminal Vesicle and Prostate
title_fullStr	Effect of Flutamide in Mouse Spermatogenesis and on the Function of Seminal Vesicle and Prostate
title_full_unstemmed	Effect of Flutamide in Mouse Spermatogenesis and on the Function of Seminal Vesicle and Prostate
title_sort	effect of flutamide in mouse spermatogenesis and on the function of seminal vesicle and prostate
publisher	Sociedad Chilena de Anatomía
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300008
work_keys_str_mv	AT bustosobregoneduardo effectofflutamideinmousespermatogenesisandonthefunctionofseminalvesicleandprostate AT espondapedro effectofflutamideinmousespermatogenesisandonthefunctionofseminalvesicleandprostate AT sarabialuis effectofflutamideinmousespermatogenesisandonthefunctionofseminalvesicleandprostate
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Effect of Flutamide in Mouse Spermatogenesis and on the Function of Seminal Vesicle and Prostate

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