p53 Immunoexpression in Oral Squamous Cell Carcinomas from Different Anatomical Sites: A Comparative Study

p53 alterations have been implicated in oral carcinogenesis process. Squamous cell carcinoma is the most common malignancy of the oral cavity, the tongue being the most frequent affected site. The aim of this study was to compare p53 immunoexpression in 43 samples of oral SCC from 5 different anatom...

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Autores principales:	Sá,Cláudia T., Fonseca,Linaena M. S., Cardoso,Sérgio V., Aguiar,Maria Cássia F., Carmo,Maria Auxiliadora V. do
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2006
Materias:	p53 protein Immunohistochemistry Oral squamous cell carcinoma (OSCC)
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300018
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spelling	oai:scielo:S0717-950220060003000182006-08-28p53 Immunoexpression in Oral Squamous Cell Carcinomas from Different Anatomical Sites: A Comparative StudySá,Cláudia T.Fonseca,Linaena M. S.Cardoso,Sérgio V.Aguiar,Maria Cássia F.Carmo,Maria Auxiliadora V. do p53 protein Immunohistochemistry Oral squamous cell carcinoma (OSCC) p53 alterations have been implicated in oral carcinogenesis process. Squamous cell carcinoma is the most common malignancy of the oral cavity, the tongue being the most frequent affected site. The aim of this study was to compare p53 immunoexpression in 43 samples of oral SCC from 5 different anatomical sites: tongue, floor of the mouth, alveolar ridge/gingiva, retromolar region and other regions of the oral cavity. Thirty-three lesions (76,8%) showed positivity for p53 (mean index of 48,37%). No statistically significant differences were found between p53 expression and the different oral sites analyzed. Similarly, no differences were found when comparing tongue lesions with the remaining sites. These results suggest that it might not exist any difference among oral cavity anatomical sites in relation to p53 immunoexpression. Moreover, mechanisms other than p53 alterations in squamous cell carcinomas of the tongue may be of relevance for the higher tumour aggressiveness found in this anatomical siteinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.24 n.2 20062006-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300018en10.4067/S0717-95022006000300018
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	p53 protein Immunohistochemistry Oral squamous cell carcinoma (OSCC)
spellingShingle	p53 protein Immunohistochemistry Oral squamous cell carcinoma (OSCC) Sá,Cláudia T. Fonseca,Linaena M. S. Cardoso,Sérgio V. Aguiar,Maria Cássia F. Carmo,Maria Auxiliadora V. do p53 Immunoexpression in Oral Squamous Cell Carcinomas from Different Anatomical Sites: A Comparative Study
description	p53 alterations have been implicated in oral carcinogenesis process. Squamous cell carcinoma is the most common malignancy of the oral cavity, the tongue being the most frequent affected site. The aim of this study was to compare p53 immunoexpression in 43 samples of oral SCC from 5 different anatomical sites: tongue, floor of the mouth, alveolar ridge/gingiva, retromolar region and other regions of the oral cavity. Thirty-three lesions (76,8%) showed positivity for p53 (mean index of 48,37%). No statistically significant differences were found between p53 expression and the different oral sites analyzed. Similarly, no differences were found when comparing tongue lesions with the remaining sites. These results suggest that it might not exist any difference among oral cavity anatomical sites in relation to p53 immunoexpression. Moreover, mechanisms other than p53 alterations in squamous cell carcinomas of the tongue may be of relevance for the higher tumour aggressiveness found in this anatomical site
author	Sá,Cláudia T. Fonseca,Linaena M. S. Cardoso,Sérgio V. Aguiar,Maria Cássia F. Carmo,Maria Auxiliadora V. do
author_facet	Sá,Cláudia T. Fonseca,Linaena M. S. Cardoso,Sérgio V. Aguiar,Maria Cássia F. Carmo,Maria Auxiliadora V. do
author_sort	Sá,Cláudia T.
title	p53 Immunoexpression in Oral Squamous Cell Carcinomas from Different Anatomical Sites: A Comparative Study
title_short	p53 Immunoexpression in Oral Squamous Cell Carcinomas from Different Anatomical Sites: A Comparative Study
title_full	p53 Immunoexpression in Oral Squamous Cell Carcinomas from Different Anatomical Sites: A Comparative Study
title_fullStr	p53 Immunoexpression in Oral Squamous Cell Carcinomas from Different Anatomical Sites: A Comparative Study
title_full_unstemmed	p53 Immunoexpression in Oral Squamous Cell Carcinomas from Different Anatomical Sites: A Comparative Study
title_sort	p53 immunoexpression in oral squamous cell carcinomas from different anatomical sites: a comparative study
publisher	Sociedad Chilena de Anatomía
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300018
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p53 Immunoexpression in Oral Squamous Cell Carcinomas from Different Anatomical Sites: A Comparative Study

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