Beneficial Effects of Angiotensin II AT1 Blocker on Cardiovascular Adverse Remodeling Due to Nitric Oxide Synthesis Blockade

We studied with morphological tools the effects of different doses of Losartan upon the cardiovascular remodeling in nitric oxide deficient rats. At 15 weeks of age, thirty Wistar rats were separated in six groups: control (C), L-NAME (LN), and four groups were LN was given plus Losartan at differen...

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Autores principales:	Fernandes-Santos,Caroline, Mendonça,Leonardo de Souza, Mandarim-de-Lacerda,Carlos Alberto
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2006
Materias:	Losartan Angiotensin II L-NAME Hypertension Renin-angiotensin system Stereology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400003
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spelling	oai:scielo:S0717-950220060004000032007-01-24Beneficial Effects of Angiotensin II AT1 Blocker on Cardiovascular Adverse Remodeling Due to Nitric Oxide Synthesis BlockadeFernandes-Santos,CarolineMendonça,Leonardo de SouzaMandarim-de-Lacerda,Carlos Alberto Losartan Angiotensin II L-NAME Hypertension Renin-angiotensin system Stereology L-NAME We studied with morphological tools the effects of different doses of Losartan upon the cardiovascular remodeling in nitric oxide deficient rats. At 15 weeks of age, thirty Wistar rats were separated in six groups: control (C), L-NAME (LN), and four groups were LN was given plus Losartan at different doses (1, 5, 20 and 40 mg/kg/day). The L-NAME was given for 9 weeks, the Losartan administration starting on the 2nd week of experiment. We studied the heart, thoracic aorta and superior mesenteric artery with light microscopy and stereology. The blood pressure (BP) increased since the first week of L-NAME administration, the Losartan treatment at doses of 20 and 40 mg/kg/day was efficient to reduce BP after the 7th week of treatment. The cardiac adverse remodeling in the LN group was characterized by intense interstitial fibrosis, impairment of the myocardial microvascularization, cardiomyocyte hypertrophy and consequent loss of cardiomyocytes. The aortic wall structure (density per area of smooth muscle cell nuclei and surface density of lamellae), and the superior mesenteric artery media/lumen ratio were also strongly affected by L-NAME administration. Only in the dose equal or higher than 20 mg/kg/day Losartan showed beneficial effects treating these alterations. In conclusion, both the heart and the arterial wall of NO deficient rats suffer a marked adverse remodeling process that is efficiently treated by a dose-dependent Losartan administration. The efficiency of Losartan treatment in this model of NO synthesis blockade correlates with the hypotensor effect of the drug mainly in the high dose treatmentinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.24 n.3 20062006-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400003en10.4067/S0717-95022006000400003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Losartan Angiotensin II L-NAME Hypertension Renin-angiotensin system Stereology L-NAME
spellingShingle	Losartan Angiotensin II L-NAME Hypertension Renin-angiotensin system Stereology L-NAME Fernandes-Santos,Caroline Mendonça,Leonardo de Souza Mandarim-de-Lacerda,Carlos Alberto Beneficial Effects of Angiotensin II AT1 Blocker on Cardiovascular Adverse Remodeling Due to Nitric Oxide Synthesis Blockade
description	We studied with morphological tools the effects of different doses of Losartan upon the cardiovascular remodeling in nitric oxide deficient rats. At 15 weeks of age, thirty Wistar rats were separated in six groups: control (C), L-NAME (LN), and four groups were LN was given plus Losartan at different doses (1, 5, 20 and 40 mg/kg/day). The L-NAME was given for 9 weeks, the Losartan administration starting on the 2nd week of experiment. We studied the heart, thoracic aorta and superior mesenteric artery with light microscopy and stereology. The blood pressure (BP) increased since the first week of L-NAME administration, the Losartan treatment at doses of 20 and 40 mg/kg/day was efficient to reduce BP after the 7th week of treatment. The cardiac adverse remodeling in the LN group was characterized by intense interstitial fibrosis, impairment of the myocardial microvascularization, cardiomyocyte hypertrophy and consequent loss of cardiomyocytes. The aortic wall structure (density per area of smooth muscle cell nuclei and surface density of lamellae), and the superior mesenteric artery media/lumen ratio were also strongly affected by L-NAME administration. Only in the dose equal or higher than 20 mg/kg/day Losartan showed beneficial effects treating these alterations. In conclusion, both the heart and the arterial wall of NO deficient rats suffer a marked adverse remodeling process that is efficiently treated by a dose-dependent Losartan administration. The efficiency of Losartan treatment in this model of NO synthesis blockade correlates with the hypotensor effect of the drug mainly in the high dose treatment
author	Fernandes-Santos,Caroline Mendonça,Leonardo de Souza Mandarim-de-Lacerda,Carlos Alberto
author_facet	Fernandes-Santos,Caroline Mendonça,Leonardo de Souza Mandarim-de-Lacerda,Carlos Alberto
author_sort	Fernandes-Santos,Caroline
title	Beneficial Effects of Angiotensin II AT1 Blocker on Cardiovascular Adverse Remodeling Due to Nitric Oxide Synthesis Blockade
title_short	Beneficial Effects of Angiotensin II AT1 Blocker on Cardiovascular Adverse Remodeling Due to Nitric Oxide Synthesis Blockade
title_full	Beneficial Effects of Angiotensin II AT1 Blocker on Cardiovascular Adverse Remodeling Due to Nitric Oxide Synthesis Blockade
title_fullStr	Beneficial Effects of Angiotensin II AT1 Blocker on Cardiovascular Adverse Remodeling Due to Nitric Oxide Synthesis Blockade
title_full_unstemmed	Beneficial Effects of Angiotensin II AT1 Blocker on Cardiovascular Adverse Remodeling Due to Nitric Oxide Synthesis Blockade
title_sort	beneficial effects of angiotensin ii at1 blocker on cardiovascular adverse remodeling due to nitric oxide synthesis blockade
publisher	Sociedad Chilena de Anatomía
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400003
work_keys_str_mv	AT fernandessantoscaroline beneficialeffectsofangiotensiniiat1blockeroncardiovascularadverseremodelingduetonitricoxidesynthesisblockade AT mendoncaleonardodesouza beneficialeffectsofangiotensiniiat1blockeroncardiovascularadverseremodelingduetonitricoxidesynthesisblockade AT mandarimdelacerdacarlosalberto beneficialeffectsofangiotensiniiat1blockeroncardiovascularadverseremodelingduetonitricoxidesynthesisblockade
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Beneficial Effects of Angiotensin II AT1 Blocker on Cardiovascular Adverse Remodeling Due to Nitric Oxide Synthesis Blockade

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