Chromosome Instability in Carcinomas

In the current carcinogenesis models, the occurrence of increasing mutations and selection mechanisms favoring cell survival and higher proliferation rates are taken into account. Epigenetic mechanisms, among which DNA methylation stands out, also take part in oncogenesis. The characteristic of tumo...

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Autores principales:	Assumpção,Paulo Pimentel de, Seabra,Aline Damasceno, Leal,Mariana Ferreira, Guimarães,Adriana Costa, Calcagno,Danielle Queiroz, Khayat,André Salim, Smith,Marilia de Arruda Cardoso, Burbano,Rommel Rodriguez
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2006
Materias:	Chromosomal instability Carcinomas Aneuploidies
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400007
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spelling	oai:scielo:S0717-950220060004000072007-01-24Chromosome Instability in CarcinomasAssumpção,Paulo Pimentel deSeabra,Aline DamascenoLeal,Mariana FerreiraGuimarães,Adriana CostaCalcagno,Danielle QueirozKhayat,André SalimSmith,Marilia de Arruda CardosoBurbano,Rommel Rodriguez Chromosomal instability Carcinomas Aneuploidies In the current carcinogenesis models, the occurrence of increasing mutations and selection mechanisms favoring cell survival and higher proliferation rates are taken into account. Epigenetic mechanisms, among which DNA methylation stands out, also take part in oncogenesis. The characteristic of tumor cells that allows the increase of mutations is named genetic instability, encompassing two mechanisms: microsatellite instability, characterized by nucleotide alterations with errors in the DNA repair systems; and chromosomal instability, represented by aberrations occurring in large chromosome segments. Carcinomas are characterized by complex cytogenetic alterations and large gene amalgamations. Telomeric alterations, inadequately repaired DNA breaks, and deficiencies in the mitotic spindle checking systems are events capable of generating the chromosomal instability and aneuploidy which characterize more aggressive neoplasias. A better understanding of the chromosomal instability mechanisms can show the way towards a clinical utilization of such information, like developing more adequate therapeutic strategies, targeted at specific sites involved in the malignization processinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.24 n.3 20062006-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400007en10.4067/S0717-95022006000400007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Chromosomal instability Carcinomas Aneuploidies
spellingShingle	Chromosomal instability Carcinomas Aneuploidies Assumpção,Paulo Pimentel de Seabra,Aline Damasceno Leal,Mariana Ferreira Guimarães,Adriana Costa Calcagno,Danielle Queiroz Khayat,André Salim Smith,Marilia de Arruda Cardoso Burbano,Rommel Rodriguez Chromosome Instability in Carcinomas
description	In the current carcinogenesis models, the occurrence of increasing mutations and selection mechanisms favoring cell survival and higher proliferation rates are taken into account. Epigenetic mechanisms, among which DNA methylation stands out, also take part in oncogenesis. The characteristic of tumor cells that allows the increase of mutations is named genetic instability, encompassing two mechanisms: microsatellite instability, characterized by nucleotide alterations with errors in the DNA repair systems; and chromosomal instability, represented by aberrations occurring in large chromosome segments. Carcinomas are characterized by complex cytogenetic alterations and large gene amalgamations. Telomeric alterations, inadequately repaired DNA breaks, and deficiencies in the mitotic spindle checking systems are events capable of generating the chromosomal instability and aneuploidy which characterize more aggressive neoplasias. A better understanding of the chromosomal instability mechanisms can show the way towards a clinical utilization of such information, like developing more adequate therapeutic strategies, targeted at specific sites involved in the malignization process
author	Assumpção,Paulo Pimentel de Seabra,Aline Damasceno Leal,Mariana Ferreira Guimarães,Adriana Costa Calcagno,Danielle Queiroz Khayat,André Salim Smith,Marilia de Arruda Cardoso Burbano,Rommel Rodriguez
author_facet	Assumpção,Paulo Pimentel de Seabra,Aline Damasceno Leal,Mariana Ferreira Guimarães,Adriana Costa Calcagno,Danielle Queiroz Khayat,André Salim Smith,Marilia de Arruda Cardoso Burbano,Rommel Rodriguez
author_sort	Assumpção,Paulo Pimentel de
title	Chromosome Instability in Carcinomas
title_short	Chromosome Instability in Carcinomas
title_full	Chromosome Instability in Carcinomas
title_fullStr	Chromosome Instability in Carcinomas
title_full_unstemmed	Chromosome Instability in Carcinomas
title_sort	chromosome instability in carcinomas
publisher	Sociedad Chilena de Anatomía
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400007
work_keys_str_mv	AT assumpcaopaulopimentelde chromosomeinstabilityincarcinomas AT seabraalinedamasceno chromosomeinstabilityincarcinomas AT lealmarianaferreira chromosomeinstabilityincarcinomas AT guimaraesadrianacosta chromosomeinstabilityincarcinomas AT calcagnodaniellequeiroz chromosomeinstabilityincarcinomas AT khayatandresalim chromosomeinstabilityincarcinomas AT smithmariliadearrudacardoso chromosomeinstabilityincarcinomas AT burbanorommelrodriguez chromosomeinstabilityincarcinomas
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Chromosome Instability in Carcinomas

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