Effects of Chronic Simulated Hypobaric Hypoxia on Mouse Spermatogenesis

Reduction of O2 delivery to tissues damage them, including the seminiferous epithelium. Recently, population working in high altitude has increased, so that the study of hypobaric hypoxia on spermatogenesis becomes of interest. In this study we used two groups of male, sexually mature mice Control (...

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Autores principales:	Bustos-Obregón,Eduardo, Esveile,Christian, Contreras,Julio, Maurer,Inge, Sarabia,Luis
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2006
Materias:	Hypoxia Lipoperoxidation Mouse Testis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400030
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spelling	oai:scielo:S0717-950220060004000302007-01-24Effects of Chronic Simulated Hypobaric Hypoxia on Mouse SpermatogenesisBustos-Obregón,EduardoEsveile,ChristianContreras,JulioMaurer,IngeSarabia,Luis Hypoxia Lipoperoxidation Mouse Testis Reduction of O2 delivery to tissues damage them, including the seminiferous epithelium. Recently, population working in high altitude has increased, so that the study of hypobaric hypoxia on spermatogenesis becomes of interest. In this study we used two groups of male, sexually mature mice Control (C) (540 meters above sea level (masl)) and chronic simulated hypobaric hypoxia (CSHH) (4,600 masl) exposed during 8, 16, 24 or 33 days. Hematocrit; reticulocytosis; testicular, epididymal and seminal vesicle weight; seminiferous epithelium height, tubular diameter, sperm count and morphology and testicular parenchyme and spermatozoa membranes lipoperoxidation were measured. Weight of testis, epididymis and seminal vesicle were reduced but they recuperate at 33 days. Tubular diameter and epithelial height are reduced, subsequently they tend to increase without returning to normal values. The count and sperm morphology fluctuate along the exposure time. Lipoperoxidation levels of spermatozoa and testicular parenchyme are reduced. Therefore, we can conclude that exposure to CSHH induce damage in the seminiferous epithelium, decrease of lipoperoxidation in spermatozoa and testicular tissue, and damages the testicular and sperm morphologyinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.24 n.3 20062006-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400030en10.4067/S0717-95022006000400030
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hypoxia Lipoperoxidation Mouse Testis
spellingShingle	Hypoxia Lipoperoxidation Mouse Testis Bustos-Obregón,Eduardo Esveile,Christian Contreras,Julio Maurer,Inge Sarabia,Luis Effects of Chronic Simulated Hypobaric Hypoxia on Mouse Spermatogenesis
description	Reduction of O2 delivery to tissues damage them, including the seminiferous epithelium. Recently, population working in high altitude has increased, so that the study of hypobaric hypoxia on spermatogenesis becomes of interest. In this study we used two groups of male, sexually mature mice Control (C) (540 meters above sea level (masl)) and chronic simulated hypobaric hypoxia (CSHH) (4,600 masl) exposed during 8, 16, 24 or 33 days. Hematocrit; reticulocytosis; testicular, epididymal and seminal vesicle weight; seminiferous epithelium height, tubular diameter, sperm count and morphology and testicular parenchyme and spermatozoa membranes lipoperoxidation were measured. Weight of testis, epididymis and seminal vesicle were reduced but they recuperate at 33 days. Tubular diameter and epithelial height are reduced, subsequently they tend to increase without returning to normal values. The count and sperm morphology fluctuate along the exposure time. Lipoperoxidation levels of spermatozoa and testicular parenchyme are reduced. Therefore, we can conclude that exposure to CSHH induce damage in the seminiferous epithelium, decrease of lipoperoxidation in spermatozoa and testicular tissue, and damages the testicular and sperm morphology
author	Bustos-Obregón,Eduardo Esveile,Christian Contreras,Julio Maurer,Inge Sarabia,Luis
author_facet	Bustos-Obregón,Eduardo Esveile,Christian Contreras,Julio Maurer,Inge Sarabia,Luis
author_sort	Bustos-Obregón,Eduardo
title	Effects of Chronic Simulated Hypobaric Hypoxia on Mouse Spermatogenesis
title_short	Effects of Chronic Simulated Hypobaric Hypoxia on Mouse Spermatogenesis
title_full	Effects of Chronic Simulated Hypobaric Hypoxia on Mouse Spermatogenesis
title_fullStr	Effects of Chronic Simulated Hypobaric Hypoxia on Mouse Spermatogenesis
title_full_unstemmed	Effects of Chronic Simulated Hypobaric Hypoxia on Mouse Spermatogenesis
title_sort	effects of chronic simulated hypobaric hypoxia on mouse spermatogenesis
publisher	Sociedad Chilena de Anatomía
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400030
work_keys_str_mv	AT bustosobregoneduardo effectsofchronicsimulatedhypobarichypoxiaonmousespermatogenesis AT esveilechristian effectsofchronicsimulatedhypobarichypoxiaonmousespermatogenesis AT contrerasjulio effectsofchronicsimulatedhypobarichypoxiaonmousespermatogenesis AT maureringe effectsofchronicsimulatedhypobarichypoxiaonmousespermatogenesis AT sarabialuis effectsofchronicsimulatedhypobarichypoxiaonmousespermatogenesis
_version_	1718444587540807680

Effects of Chronic Simulated Hypobaric Hypoxia on Mouse Spermatogenesis

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