Maternal Chronic Stress Induces Premature Telencephalic Vesicles Development

Exposure to physical or psychological stress causes brain damage ranging from minimal behavioural alterations to different neurodegeneration degrees implying the overproduction of oxidative-nitrosative compounds, apoptosis and cell proliferation. In the present investigation, we have analysed the ef...

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Autores principales:	Mugnaini,María Teresa, Soñez,Carlos Alberto, Rolando,Alicia Nélida, Romanini,María Cristina, Bozzo,Aída Andrea, Pastorino,Isabel Cecilia, Gauna,Héctor Fernando, Paz,Dante Agustín
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2006
Materias:	Telencephalic vesicle Chronic stress Morphometric analysis Rats
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000500001
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spelling	oai:scielo:S0717-950220060005000012007-05-09Maternal Chronic Stress Induces Premature Telencephalic Vesicles DevelopmentMugnaini,María TeresaSoñez,Carlos AlbertoRolando,Alicia NélidaRomanini,María CristinaBozzo,Aída AndreaPastorino,Isabel CeciliaGauna,Héctor FernandoPaz,Dante Agustín Telencephalic vesicle Chronic stress Morphometric analysis Rats Exposure to physical or psychological stress causes brain damage ranging from minimal behavioural alterations to different neurodegeneration degrees implying the overproduction of oxidative-nitrosative compounds, apoptosis and cell proliferation. In the present investigation, we have analysed the effect of the chronic stress by immobilisation applied to pregnant rats over the forebrain development of the embryos. The morphometric analyses showed an accelerated evagination of the telencephalic vesicles in 12 days old fetus from stressed mothers. The forebrain perimeter and the thickness showed significative differences in relation to age-matched controls. This stress effect seemed reversible during subsequent gestational stages. This is the first work showing a transient acceleration in the development induced by the gestational stress. Our model provides a new tool for studying the effect of the stress on the developmentinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.24 n.4 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000500001en10.4067/S0717-95022006000500001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Telencephalic vesicle Chronic stress Morphometric analysis Rats
spellingShingle	Telencephalic vesicle Chronic stress Morphometric analysis Rats Mugnaini,María Teresa Soñez,Carlos Alberto Rolando,Alicia Nélida Romanini,María Cristina Bozzo,Aída Andrea Pastorino,Isabel Cecilia Gauna,Héctor Fernando Paz,Dante Agustín Maternal Chronic Stress Induces Premature Telencephalic Vesicles Development
description	Exposure to physical or psychological stress causes brain damage ranging from minimal behavioural alterations to different neurodegeneration degrees implying the overproduction of oxidative-nitrosative compounds, apoptosis and cell proliferation. In the present investigation, we have analysed the effect of the chronic stress by immobilisation applied to pregnant rats over the forebrain development of the embryos. The morphometric analyses showed an accelerated evagination of the telencephalic vesicles in 12 days old fetus from stressed mothers. The forebrain perimeter and the thickness showed significative differences in relation to age-matched controls. This stress effect seemed reversible during subsequent gestational stages. This is the first work showing a transient acceleration in the development induced by the gestational stress. Our model provides a new tool for studying the effect of the stress on the development
author	Mugnaini,María Teresa Soñez,Carlos Alberto Rolando,Alicia Nélida Romanini,María Cristina Bozzo,Aída Andrea Pastorino,Isabel Cecilia Gauna,Héctor Fernando Paz,Dante Agustín
author_facet	Mugnaini,María Teresa Soñez,Carlos Alberto Rolando,Alicia Nélida Romanini,María Cristina Bozzo,Aída Andrea Pastorino,Isabel Cecilia Gauna,Héctor Fernando Paz,Dante Agustín
author_sort	Mugnaini,María Teresa
title	Maternal Chronic Stress Induces Premature Telencephalic Vesicles Development
title_short	Maternal Chronic Stress Induces Premature Telencephalic Vesicles Development
title_full	Maternal Chronic Stress Induces Premature Telencephalic Vesicles Development
title_fullStr	Maternal Chronic Stress Induces Premature Telencephalic Vesicles Development
title_full_unstemmed	Maternal Chronic Stress Induces Premature Telencephalic Vesicles Development
title_sort	maternal chronic stress induces premature telencephalic vesicles development
publisher	Sociedad Chilena de Anatomía
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000500001
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Maternal Chronic Stress Induces Premature Telencephalic Vesicles Development

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