Morphometric Analysis of Mice Testicular Tubules after Administration of Malathion and Maca

Organophosphoric (OP) agropesticidas are amply used to increase food production. However, it has been verified that they induce alterations at testicular level related to the diminution of fertility in humans as in animals. On the other hand, different studies have been made to develop chemical or n...

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Autores principales:	Bustos-Obregón,Eduardo, del Río,Fernando Costa, Sarabia,Luis
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2007
Materias:	Testis Morphometry Mice Malathion Maca
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200001
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spelling	oai:scielo:S0717-950220070002000012007-08-30Morphometric Analysis of Mice Testicular Tubules after Administration of Malathion and MacaBustos-Obregón,Eduardodel Río,Fernando CostaSarabia,Luis Testis Morphometry Mice Malathion Maca Organophosphoric (OP) agropesticidas are amply used to increase food production. However, it has been verified that they induce alterations at testicular level related to the diminution of fertility in humans as in animals. On the other hand, different studies have been made to develop chemical or natural compounds that can induce an antagonistic effect to OP. In previous studies an extract from a plant, from the Peruvian Andes (Maca) has been recognized by its stimulating action on spermatogenesis. In the present study the effects of both external agents were evaluated on testicular sections of testis of adult male mice on a population of 52 mice CF1, divided at random in 4 groups (Control, Malathion, Maca, Malathion-Maca), with sacrifice intervals of 1,7, 14 and 21 days. By means of morphometric technique and using the "Image Tools 3,1" software, the histology of testicular sections was evaluated, to analyze the degree of alteration induced by these agents. The epithelial height mainly has a rise in day 1, for Malathion group and then fall to day 7 to be normal by day 14. However, Malathion-Maca groups show no changes. The tubular lumen decreases at day 7 and day 14 to be normal by day 21 in Malathion group. However, in Malathion - Maca group, the tubular lumen decreases only at 14 days. The tubular diameter, at day 7 (p<0.01), 14 and 21 in Malathion group decreases respect to control (p<0.05), However, Malathion-Maca groups show normal values. In conclusion, it is possible to establish that the damage induced by Malathion is reverted by 21 days post-administration of Macainfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.25 n.2 20072007-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200001en10.4067/S0717-95022007000200001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Testis Morphometry Mice Malathion Maca
spellingShingle	Testis Morphometry Mice Malathion Maca Bustos-Obregón,Eduardo del Río,Fernando Costa Sarabia,Luis Morphometric Analysis of Mice Testicular Tubules after Administration of Malathion and Maca
description	Organophosphoric (OP) agropesticidas are amply used to increase food production. However, it has been verified that they induce alterations at testicular level related to the diminution of fertility in humans as in animals. On the other hand, different studies have been made to develop chemical or natural compounds that can induce an antagonistic effect to OP. In previous studies an extract from a plant, from the Peruvian Andes (Maca) has been recognized by its stimulating action on spermatogenesis. In the present study the effects of both external agents were evaluated on testicular sections of testis of adult male mice on a population of 52 mice CF1, divided at random in 4 groups (Control, Malathion, Maca, Malathion-Maca), with sacrifice intervals of 1,7, 14 and 21 days. By means of morphometric technique and using the "Image Tools 3,1" software, the histology of testicular sections was evaluated, to analyze the degree of alteration induced by these agents. The epithelial height mainly has a rise in day 1, for Malathion group and then fall to day 7 to be normal by day 14. However, Malathion-Maca groups show no changes. The tubular lumen decreases at day 7 and day 14 to be normal by day 21 in Malathion group. However, in Malathion - Maca group, the tubular lumen decreases only at 14 days. The tubular diameter, at day 7 (p<0.01), 14 and 21 in Malathion group decreases respect to control (p<0.05), However, Malathion-Maca groups show normal values. In conclusion, it is possible to establish that the damage induced by Malathion is reverted by 21 days post-administration of Maca
author	Bustos-Obregón,Eduardo del Río,Fernando Costa Sarabia,Luis
author_facet	Bustos-Obregón,Eduardo del Río,Fernando Costa Sarabia,Luis
author_sort	Bustos-Obregón,Eduardo
title	Morphometric Analysis of Mice Testicular Tubules after Administration of Malathion and Maca
title_short	Morphometric Analysis of Mice Testicular Tubules after Administration of Malathion and Maca
title_full	Morphometric Analysis of Mice Testicular Tubules after Administration of Malathion and Maca
title_fullStr	Morphometric Analysis of Mice Testicular Tubules after Administration of Malathion and Maca
title_full_unstemmed	Morphometric Analysis of Mice Testicular Tubules after Administration of Malathion and Maca
title_sort	morphometric analysis of mice testicular tubules after administration of malathion and maca
publisher	Sociedad Chilena de Anatomía
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200001
work_keys_str_mv	AT bustosobregoneduardo morphometricanalysisofmicetesticulartubulesafteradministrationofmalathionandmaca AT delriofernandocosta morphometricanalysisofmicetesticulartubulesafteradministrationofmalathionandmaca AT sarabialuis morphometricanalysisofmicetesticulartubulesafteradministrationofmalathionandmaca
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Morphometric Analysis of Mice Testicular Tubules after Administration of Malathion and Maca

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