Histological Study on the Male Reproductive Organs of Mouse CF1 Treated With Boron

Boric acid and borate are abundant in the nature and widely used in industrial, agricultural and cosmetology applications. However it is informed as toxic in a high dose. Residents of Arica-Chile with boron-rich geology deposits are regularly exposed to higher levels in drinking water in concentrati...

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Autores principales:	Espinoza-Navarro,O, Vilaxa,A, Granifo,L, Rojas,S, Rodríguez,H
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2007
Materias:	Boric acid Spermatogenesis Testicular atrophy Mouse
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200017
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spelling	oai:scielo:S0717-950220070002000172007-08-30Histological Study on the Male Reproductive Organs of Mouse CF1 Treated With BoronEspinoza-Navarro,OVilaxa,AGranifo,LRojas,SRodríguez,H Boric acid Spermatogenesis Testicular atrophy Mouse Boric acid and borate are abundant in the nature and widely used in industrial, agricultural and cosmetology applications. However it is informed as toxic in a high dose. Residents of Arica-Chile with boron-rich geology deposits are regularly exposed to higher levels in drinking water in concentrations of 6. 0 and 12.0 mg/L. The objective of this study was to analyze the damage in the masculine reproductive apparatus of mouse CF1, exposed to boric acid in concentrations of 0.54; 2.0-6.0 and 12.0 mg/L, after 60 days of treatment. Male gonad segments were fixed in Bouin's solution for 6 hours and embedded in paraffin, longitudinal sections (5 mm) were processed for histology using the hematoxyline/eosin method. The results observed in treated animals indicate a significant increase in the weight, volume and size of testicles and seminal vesicles. The histological analysis of testicle shows in treated an epithelium notoriously altered with vacuohzations, scarce gonias and few spermatids. Gonias present picnoticals nuclei, suggesting apoptosis. In conclusion boron in high dose produces important cytotoxics effects, with degeneration of epithelium of seminiferous tubules, possibly inhibiting the spermiation, causing testicular hypertrophy, altering the masculine reproductive patterns and a reduction in fertility of mice CF1info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.25 n.2 20072007-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200017en10.4067/S0717-95022007000200017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Boric acid Spermatogenesis Testicular atrophy Mouse
spellingShingle	Boric acid Spermatogenesis Testicular atrophy Mouse Espinoza-Navarro,O Vilaxa,A Granifo,L Rojas,S Rodríguez,H Histological Study on the Male Reproductive Organs of Mouse CF1 Treated With Boron
description	Boric acid and borate are abundant in the nature and widely used in industrial, agricultural and cosmetology applications. However it is informed as toxic in a high dose. Residents of Arica-Chile with boron-rich geology deposits are regularly exposed to higher levels in drinking water in concentrations of 6. 0 and 12.0 mg/L. The objective of this study was to analyze the damage in the masculine reproductive apparatus of mouse CF1, exposed to boric acid in concentrations of 0.54; 2.0-6.0 and 12.0 mg/L, after 60 days of treatment. Male gonad segments were fixed in Bouin's solution for 6 hours and embedded in paraffin, longitudinal sections (5 mm) were processed for histology using the hematoxyline/eosin method. The results observed in treated animals indicate a significant increase in the weight, volume and size of testicles and seminal vesicles. The histological analysis of testicle shows in treated an epithelium notoriously altered with vacuohzations, scarce gonias and few spermatids. Gonias present picnoticals nuclei, suggesting apoptosis. In conclusion boron in high dose produces important cytotoxics effects, with degeneration of epithelium of seminiferous tubules, possibly inhibiting the spermiation, causing testicular hypertrophy, altering the masculine reproductive patterns and a reduction in fertility of mice CF1
author	Espinoza-Navarro,O Vilaxa,A Granifo,L Rojas,S Rodríguez,H
author_facet	Espinoza-Navarro,O Vilaxa,A Granifo,L Rojas,S Rodríguez,H
author_sort	Espinoza-Navarro,O
title	Histological Study on the Male Reproductive Organs of Mouse CF1 Treated With Boron
title_short	Histological Study on the Male Reproductive Organs of Mouse CF1 Treated With Boron
title_full	Histological Study on the Male Reproductive Organs of Mouse CF1 Treated With Boron
title_fullStr	Histological Study on the Male Reproductive Organs of Mouse CF1 Treated With Boron
title_full_unstemmed	Histological Study on the Male Reproductive Organs of Mouse CF1 Treated With Boron
title_sort	histological study on the male reproductive organs of mouse cf1 treated with boron
publisher	Sociedad Chilena de Anatomía
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200017
work_keys_str_mv	AT espinozanavarroo histologicalstudyonthemalereproductiveorgansofmousecf1treatedwithboron AT vilaxaa histologicalstudyonthemalereproductiveorgansofmousecf1treatedwithboron AT granifol histologicalstudyonthemalereproductiveorgansofmousecf1treatedwithboron AT rojass histologicalstudyonthemalereproductiveorgansofmousecf1treatedwithboron AT rodriguezh histologicalstudyonthemalereproductiveorgansofmousecf1treatedwithboron
_version_	1718444601962921984

Histological Study on the Male Reproductive Organs of Mouse CF1 Treated With Boron

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