Regulation of the Bone Healing Process by Hormones

The skeleton has several important functions, such as structural functions that provide mobility, support, and protection for the body. It also has an important function as a reservoir for calcium and phosphorus. The aim of this article is to show the principal hormones that are involved with the bo...

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Autores principales:	Issa,Joáo Paulo Mardegan, Tiossi,Rodrigo, Mello,Amaro Sergio da Silva, Iyomasa,Mamie Mizusaki
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2007
Materias:	Bone Repair Hormones
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200025
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spelling	oai:scielo:S0717-950220070002000252007-08-30Regulation of the Bone Healing Process by HormonesIssa,Joáo Paulo MardeganTiossi,RodrigoMello,Amaro Sergio da SilvaIyomasa,Mamie Mizusaki Bone Repair Hormones The skeleton has several important functions, such as structural functions that provide mobility, support, and protection for the body. It also has an important function as a reservoir for calcium and phosphorus. The aim of this article is to show the principal hormones that are involved with the bone healing process. In this article, it will be pointed the mineral homeostatic mechanisms in the skeleton, controlled by the calcium-regulating hormones: parathyroid hormone (PTH) that maintains the normal extracellular calcium levels by enhancing osteoclastic bone resorption and liberating calcium from the adult skeleton; estrogen, considering that both osteoblasts and osteoclasts express estrogen receptors, it is reasonable to assume that the effects of estrogen on skeletal remodeling could be caused, at least partly, by a direct effect on bone cells; androgen with important functions on the adult male phenotype, anabolic actions on skeleton, muscle and bone, including the effects of their metabolism in diverse tissues; and steroids that inhibit the synthesis of proteins, collagen, and proteoglycans in articular cartilage, and inactivate vitamin D, limiting calcium absorption by the gastrointestinal tract, and increasing the urinary excretion of calcium, they also inhibit the release of growth hormone, which further decreases soft tissue and bone repair and lead to a decrease in bone, ligament, and tendon strengthinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.25 n.2 20072007-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200025en10.4067/S0717-95022007000200025
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Bone Repair Hormones
spellingShingle	Bone Repair Hormones Issa,Joáo Paulo Mardegan Tiossi,Rodrigo Mello,Amaro Sergio da Silva Iyomasa,Mamie Mizusaki Regulation of the Bone Healing Process by Hormones
description	The skeleton has several important functions, such as structural functions that provide mobility, support, and protection for the body. It also has an important function as a reservoir for calcium and phosphorus. The aim of this article is to show the principal hormones that are involved with the bone healing process. In this article, it will be pointed the mineral homeostatic mechanisms in the skeleton, controlled by the calcium-regulating hormones: parathyroid hormone (PTH) that maintains the normal extracellular calcium levels by enhancing osteoclastic bone resorption and liberating calcium from the adult skeleton; estrogen, considering that both osteoblasts and osteoclasts express estrogen receptors, it is reasonable to assume that the effects of estrogen on skeletal remodeling could be caused, at least partly, by a direct effect on bone cells; androgen with important functions on the adult male phenotype, anabolic actions on skeleton, muscle and bone, including the effects of their metabolism in diverse tissues; and steroids that inhibit the synthesis of proteins, collagen, and proteoglycans in articular cartilage, and inactivate vitamin D, limiting calcium absorption by the gastrointestinal tract, and increasing the urinary excretion of calcium, they also inhibit the release of growth hormone, which further decreases soft tissue and bone repair and lead to a decrease in bone, ligament, and tendon strength
author	Issa,Joáo Paulo Mardegan Tiossi,Rodrigo Mello,Amaro Sergio da Silva Iyomasa,Mamie Mizusaki
author_facet	Issa,Joáo Paulo Mardegan Tiossi,Rodrigo Mello,Amaro Sergio da Silva Iyomasa,Mamie Mizusaki
author_sort	Issa,Joáo Paulo Mardegan
title	Regulation of the Bone Healing Process by Hormones
title_short	Regulation of the Bone Healing Process by Hormones
title_full	Regulation of the Bone Healing Process by Hormones
title_fullStr	Regulation of the Bone Healing Process by Hormones
title_full_unstemmed	Regulation of the Bone Healing Process by Hormones
title_sort	regulation of the bone healing process by hormones
publisher	Sociedad Chilena de Anatomía
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200025
work_keys_str_mv	AT issajoaopaulomardegan regulationofthebonehealingprocessbyhormones AT tiossirodrigo regulationofthebonehealingprocessbyhormones AT melloamarosergiodasilva regulationofthebonehealingprocessbyhormones AT iyomasamamiemizusaki regulationofthebonehealingprocessbyhormones
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Regulation of the Bone Healing Process by Hormones

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