Polymorphism C373G of the PECAM-1 Gene in Chilean Subjects with Coronary Disease and Controls

The platelet endothelial cell adhesion molecule-1 (PECAM-1), a 130-kDa membrane glycoprotein, is expressed on the surface of monocytes, some T-lymphocyte subsets, neutrophils, platelets and endothelial cells. PECAM-1 plays a key role in the transendothelial migration of circulating leukocytes during...

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Autores principales:	Herrera,Christian L, Jaramillo,Priscilla C, Lanas,Fernando, Salazar,Luis A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2007
Materias:	Aterosclerosis PECAM-1 Polymorphism
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200031
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spelling	oai:scielo:S0717-950220070002000312007-08-30Polymorphism C373G of the PECAM-1 Gene in Chilean Subjects with Coronary Disease and ControlsHerrera,Christian LJaramillo,Priscilla CLanas,FernandoSalazar,Luis A Aterosclerosis PECAM-1 Polymorphism The platelet endothelial cell adhesion molecule-1 (PECAM-1), a 130-kDa membrane glycoprotein, is expressed on the surface of monocytes, some T-lymphocyte subsets, neutrophils, platelets and endothelial cells. PECAM-1 plays a key role in the transendothelial migration of circulating leukocytes during vascular inflammation. The aim of the present investigation was to evaluate the association between the C373G polymorphism of the PECAM-1 gene and coronary artery disease in Chilean subjects. A total of 220 individuals were investigated (112 cases and 108 controls). The presence of coronary artery disease was confirmed by angiography (Stenosis >70%). The C373G polymorphism was detected by polymerase chain reaction followed enzymatic restriction. The genotype frequencies were in agreement with those predicted by the Hardy-Weinberg equilibrium in both groups. The genotype distribution and the relative alíele frequencies for C373G polymorphism of the PECAM-1 gene were similar between cases and controls (P= 0.820 and P= 0.739, respectively). Moreover, the OR associated with the mutated G alíele was 0.92 (C.I. 95%, 0.54 - 1.57; P=NS). In summary, our study showed that C373G polymorphism of the PECAM-1 gene is not associated with coronary artery disease in the population analyzedinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.25 n.2 20072007-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200031en10.4067/S0717-95022007000200031
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Aterosclerosis PECAM-1 Polymorphism
spellingShingle	Aterosclerosis PECAM-1 Polymorphism Herrera,Christian L Jaramillo,Priscilla C Lanas,Fernando Salazar,Luis A Polymorphism C373G of the PECAM-1 Gene in Chilean Subjects with Coronary Disease and Controls
description	The platelet endothelial cell adhesion molecule-1 (PECAM-1), a 130-kDa membrane glycoprotein, is expressed on the surface of monocytes, some T-lymphocyte subsets, neutrophils, platelets and endothelial cells. PECAM-1 plays a key role in the transendothelial migration of circulating leukocytes during vascular inflammation. The aim of the present investigation was to evaluate the association between the C373G polymorphism of the PECAM-1 gene and coronary artery disease in Chilean subjects. A total of 220 individuals were investigated (112 cases and 108 controls). The presence of coronary artery disease was confirmed by angiography (Stenosis >70%). The C373G polymorphism was detected by polymerase chain reaction followed enzymatic restriction. The genotype frequencies were in agreement with those predicted by the Hardy-Weinberg equilibrium in both groups. The genotype distribution and the relative alíele frequencies for C373G polymorphism of the PECAM-1 gene were similar between cases and controls (P= 0.820 and P= 0.739, respectively). Moreover, the OR associated with the mutated G alíele was 0.92 (C.I. 95%, 0.54 - 1.57; P=NS). In summary, our study showed that C373G polymorphism of the PECAM-1 gene is not associated with coronary artery disease in the population analyzed
author	Herrera,Christian L Jaramillo,Priscilla C Lanas,Fernando Salazar,Luis A
author_facet	Herrera,Christian L Jaramillo,Priscilla C Lanas,Fernando Salazar,Luis A
author_sort	Herrera,Christian L
title	Polymorphism C373G of the PECAM-1 Gene in Chilean Subjects with Coronary Disease and Controls
title_short	Polymorphism C373G of the PECAM-1 Gene in Chilean Subjects with Coronary Disease and Controls
title_full	Polymorphism C373G of the PECAM-1 Gene in Chilean Subjects with Coronary Disease and Controls
title_fullStr	Polymorphism C373G of the PECAM-1 Gene in Chilean Subjects with Coronary Disease and Controls
title_full_unstemmed	Polymorphism C373G of the PECAM-1 Gene in Chilean Subjects with Coronary Disease and Controls
title_sort	polymorphism c373g of the pecam-1 gene in chilean subjects with coronary disease and controls
publisher	Sociedad Chilena de Anatomía
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200031
work_keys_str_mv	AT herrerachristianl polymorphismc373gofthepecam1geneinchileansubjectswithcoronarydiseaseandcontrols AT jaramillopriscillac polymorphismc373gofthepecam1geneinchileansubjectswithcoronarydiseaseandcontrols AT lanasfernando polymorphismc373gofthepecam1geneinchileansubjectswithcoronarydiseaseandcontrols AT salazarluisa polymorphismc373gofthepecam1geneinchileansubjectswithcoronarydiseaseandcontrols
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Polymorphism C373G of the PECAM-1 Gene in Chilean Subjects with Coronary Disease and Controls

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