Apoptosis in Denervated Skeletal Muscle

The apoptosis phenomenon happens in normal tissues and in many pathological conditions as described by several researchers. Most studied in the 70s, this phenomenon remained almost forgotten in the 90s, when, with the advent of more advanced techniques, returned to laboratories. Thus, electronic mic...

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Autores principales:	Davatz,Giovanna Castilho, Andreo,Jesus Carlos, Rodrigues,Antonio de Castro, Rosa Júnior,Geraldo Marco, Moraes,Luiz Henrique Rapucci
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2007
Materias:	Skeletal muscle Denervation Apoptosis Rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300009
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spelling	oai:scielo:S0717-950220070003000092007-10-30Apoptosis in Denervated Skeletal MuscleDavatz,Giovanna CastilhoAndreo,Jesus CarlosRodrigues,Antonio de CastroRosa Júnior,Geraldo MarcoMoraes,Luiz Henrique Rapucci Skeletal muscle Denervation Apoptosis Rat The apoptosis phenomenon happens in normal tissues and in many pathological conditions as described by several researchers. Most studied in the 70s, this phenomenon remained almost forgotten in the 90s, when, with the advent of more advanced techniques, returned to laboratories. Thus, electronic microscopy, Comet Assays and histochemistry techniques, among others, were utilized in an effort to elucidate in a thorough way, the mechanisms that lead the cell to "suicide". No one can deny the importance of the knowledge of such phenomenon, so as to control its induction or blocking in the treatment of pathologies such as cancer. In this work, the apoptosis study was aimed at denervated muscles in different periods. Furthermore, two types of skeletal striated muscles were compared: the one called red muscle (soleo) which is resistant to fatigue, having a slow contraction, and the one named white muscle (EDL) of precocious fatigue and fast contraction. Previoulsy carried out in the techniques mentioned above, this work has been accomplished using the TUNEL technique, which is most accepted in the identification of apoptosis. It was demonstrated that this phenomenon takes place in a more marked way, in the beginning of the denervation process. In addition, it was observed that the red muscle responds more intensely to denervation than the white muscle. One can infer that the removal of the main cell function, the contraction, in the case of the skeletal striated muscle, triggers the chain reactions that culminate in apoptosis. Other projects are in process using mutant animals aiming at studying degenerative muscular illnesses and correlating them with denervationinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.25 n.3 20072007-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300009en10.4067/S0717-95022007000300009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Skeletal muscle Denervation Apoptosis Rat
spellingShingle	Skeletal muscle Denervation Apoptosis Rat Davatz,Giovanna Castilho Andreo,Jesus Carlos Rodrigues,Antonio de Castro Rosa Júnior,Geraldo Marco Moraes,Luiz Henrique Rapucci Apoptosis in Denervated Skeletal Muscle
description	The apoptosis phenomenon happens in normal tissues and in many pathological conditions as described by several researchers. Most studied in the 70s, this phenomenon remained almost forgotten in the 90s, when, with the advent of more advanced techniques, returned to laboratories. Thus, electronic microscopy, Comet Assays and histochemistry techniques, among others, were utilized in an effort to elucidate in a thorough way, the mechanisms that lead the cell to "suicide". No one can deny the importance of the knowledge of such phenomenon, so as to control its induction or blocking in the treatment of pathologies such as cancer. In this work, the apoptosis study was aimed at denervated muscles in different periods. Furthermore, two types of skeletal striated muscles were compared: the one called red muscle (soleo) which is resistant to fatigue, having a slow contraction, and the one named white muscle (EDL) of precocious fatigue and fast contraction. Previoulsy carried out in the techniques mentioned above, this work has been accomplished using the TUNEL technique, which is most accepted in the identification of apoptosis. It was demonstrated that this phenomenon takes place in a more marked way, in the beginning of the denervation process. In addition, it was observed that the red muscle responds more intensely to denervation than the white muscle. One can infer that the removal of the main cell function, the contraction, in the case of the skeletal striated muscle, triggers the chain reactions that culminate in apoptosis. Other projects are in process using mutant animals aiming at studying degenerative muscular illnesses and correlating them with denervation
author	Davatz,Giovanna Castilho Andreo,Jesus Carlos Rodrigues,Antonio de Castro Rosa Júnior,Geraldo Marco Moraes,Luiz Henrique Rapucci
author_facet	Davatz,Giovanna Castilho Andreo,Jesus Carlos Rodrigues,Antonio de Castro Rosa Júnior,Geraldo Marco Moraes,Luiz Henrique Rapucci
author_sort	Davatz,Giovanna Castilho
title	Apoptosis in Denervated Skeletal Muscle
title_short	Apoptosis in Denervated Skeletal Muscle
title_full	Apoptosis in Denervated Skeletal Muscle
title_fullStr	Apoptosis in Denervated Skeletal Muscle
title_full_unstemmed	Apoptosis in Denervated Skeletal Muscle
title_sort	apoptosis in denervated skeletal muscle
publisher	Sociedad Chilena de Anatomía
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300009
work_keys_str_mv	AT davatzgiovannacastilho apoptosisindenervatedskeletalmuscle AT andreojesuscarlos apoptosisindenervatedskeletalmuscle AT rodriguesantoniodecastro apoptosisindenervatedskeletalmuscle AT rosajuniorgeraldomarco apoptosisindenervatedskeletalmuscle AT moraesluizhenriquerapucci apoptosisindenervatedskeletalmuscle
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Apoptosis in Denervated Skeletal Muscle

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