Study of the Nuclear Volume of Testicular Cells of Rats Receiving Ofloxacin Through Lactation

Ofloxacin presents an ample spectrum of antimicrobial action, including combating Mycobacterium leprae, and is currently employed as a substitute when the use of rifampicin is impossible. The objective of this work was to study alterations in testicular cell nuclei of suckling rats, whose dams were...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Paschoal,Vánia Del'Arco, Rossit,Andrea Batista, Bizutti,Luiz Onivaldo, Monteiro,Rodrigo, Padovani Junior,Joao Armando, Azoubel,Reinaldo
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2007
Materias:	Quinolones Ofloxacin Morphology Karyometry Nuclear volume Testicle Lactation Sustentacular cells Rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300022
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022007000300022
record_format	dspace
spelling	oai:scielo:S0717-950220070003000222007-10-30Study of the Nuclear Volume of Testicular Cells of Rats Receiving Ofloxacin Through LactationPaschoal,Vánia Del'ArcoRossit,Andrea BatistaBizutti,Luiz OnivaldoMonteiro,RodrigoPadovani Junior,Joao ArmandoAzoubel,Reinaldo Quinolones Ofloxacin Morphology Karyometry Nuclear volume Testicle Lactation Sustentacular cells Rat Ofloxacin presents an ample spectrum of antimicrobial action, including combating Mycobacterium leprae, and is currently employed as a substitute when the use of rifampicin is impossible. The objective of this work was to study alterations in testicular cell nuclei of suckling rats, whose dams were submitted to oral application of ofloxacin, and respective control groups. The method utilized was morphometry by the karyometric technique. The main structures observed in histological preparations of the testicles were interstitial cells, spermatogonias, and sustentacular cells. 10 Wistar rats were utilized, four treated and five controls, in the period of the first 25 days of life, whose dams received ofloxacin 12 mg/ Kg of body weight / day orally, before being killed on the 25th day after birth. The karyometric study of interstitial cells and spermatogonias revealed that there were no changes in the form of their nuclei (p > 0.05). Since sustentacular cell nuclei presented increased major diameter, minor diameter, mean geometric diameter, volume, area, volume/area ratio and perimeter, as well as an augmented and statistically different eccentricity (p < 0.05) in suckling pups whose dams were administered ofloxacin, the nuclei presented larger size and more elongated form. It was concluded that the sustentacular cells were more sensitive to the ofloxacin effect at the administered doseinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.25 n.3 20072007-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300022en10.4067/S0717-95022007000300022
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Quinolones Ofloxacin Morphology Karyometry Nuclear volume Testicle Lactation Sustentacular cells Rat
spellingShingle	Quinolones Ofloxacin Morphology Karyometry Nuclear volume Testicle Lactation Sustentacular cells Rat Paschoal,Vánia Del'Arco Rossit,Andrea Batista Bizutti,Luiz Onivaldo Monteiro,Rodrigo Padovani Junior,Joao Armando Azoubel,Reinaldo Study of the Nuclear Volume of Testicular Cells of Rats Receiving Ofloxacin Through Lactation
description	Ofloxacin presents an ample spectrum of antimicrobial action, including combating Mycobacterium leprae, and is currently employed as a substitute when the use of rifampicin is impossible. The objective of this work was to study alterations in testicular cell nuclei of suckling rats, whose dams were submitted to oral application of ofloxacin, and respective control groups. The method utilized was morphometry by the karyometric technique. The main structures observed in histological preparations of the testicles were interstitial cells, spermatogonias, and sustentacular cells. 10 Wistar rats were utilized, four treated and five controls, in the period of the first 25 days of life, whose dams received ofloxacin 12 mg/ Kg of body weight / day orally, before being killed on the 25th day after birth. The karyometric study of interstitial cells and spermatogonias revealed that there were no changes in the form of their nuclei (p > 0.05). Since sustentacular cell nuclei presented increased major diameter, minor diameter, mean geometric diameter, volume, area, volume/area ratio and perimeter, as well as an augmented and statistically different eccentricity (p < 0.05) in suckling pups whose dams were administered ofloxacin, the nuclei presented larger size and more elongated form. It was concluded that the sustentacular cells were more sensitive to the ofloxacin effect at the administered dose
author	Paschoal,Vánia Del'Arco Rossit,Andrea Batista Bizutti,Luiz Onivaldo Monteiro,Rodrigo Padovani Junior,Joao Armando Azoubel,Reinaldo
author_facet	Paschoal,Vánia Del'Arco Rossit,Andrea Batista Bizutti,Luiz Onivaldo Monteiro,Rodrigo Padovani Junior,Joao Armando Azoubel,Reinaldo
author_sort	Paschoal,Vánia Del'Arco
title	Study of the Nuclear Volume of Testicular Cells of Rats Receiving Ofloxacin Through Lactation
title_short	Study of the Nuclear Volume of Testicular Cells of Rats Receiving Ofloxacin Through Lactation
title_full	Study of the Nuclear Volume of Testicular Cells of Rats Receiving Ofloxacin Through Lactation
title_fullStr	Study of the Nuclear Volume of Testicular Cells of Rats Receiving Ofloxacin Through Lactation
title_full_unstemmed	Study of the Nuclear Volume of Testicular Cells of Rats Receiving Ofloxacin Through Lactation
title_sort	study of the nuclear volume of testicular cells of rats receiving ofloxacin through lactation
publisher	Sociedad Chilena de Anatomía
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300022
work_keys_str_mv	AT paschoalvaniadelarco studyofthenuclearvolumeoftesticularcellsofratsreceivingofloxacinthroughlactation AT rossitandreabatista studyofthenuclearvolumeoftesticularcellsofratsreceivingofloxacinthroughlactation AT bizuttiluizonivaldo studyofthenuclearvolumeoftesticularcellsofratsreceivingofloxacinthroughlactation AT monteirorodrigo studyofthenuclearvolumeoftesticularcellsofratsreceivingofloxacinthroughlactation AT padovanijuniorjoaoarmando studyofthenuclearvolumeoftesticularcellsofratsreceivingofloxacinthroughlactation AT azoubelreinaldo studyofthenuclearvolumeoftesticularcellsofratsreceivingofloxacinthroughlactation
_version_	1718444608512327680

Study of the Nuclear Volume of Testicular Cells of Rats Receiving Ofloxacin Through Lactation

Ejemplares similares