Toxic Effects of Methanolic Extract of Aspilia africana Leaf on the Estrous Cycle and Uterine Tissues of Wistar Rats

Effects of graded dosages of methanolic extract of Aspilia Africana were examined on the estrous cycle, uterine weights and histology to determine its effects on the reproductive functions of 25 cyclic female rats. The rats were randomized into five groups A, B, C, D, and E. They were given Omg/kg b...

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Autores principales:	Oluyemi,Kayode A, Okwuonu,Uche C, Baxter,D. Grillo, Oyesola,Tolulope, O
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2007
Materias:	Aspilia africana Estrous Uterine weight Histology Reproductive functions
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300023
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spelling	oai:scielo:S0717-950220070003000232007-10-30Toxic Effects of Methanolic Extract of Aspilia africana Leaf on the Estrous Cycle and Uterine Tissues of Wistar RatsOluyemi,Kayode AOkwuonu,Uche CBaxter,D. GrilloOyesola,Tolulope, O Aspilia africana Estrous Uterine weight Histology Reproductive functions Effects of graded dosages of methanolic extract of Aspilia Africana were examined on the estrous cycle, uterine weights and histology to determine its effects on the reproductive functions of 25 cyclic female rats. The rats were randomized into five groups A, B, C, D, and E. They were given Omg/kg body weight, 150 mg/kg body weight, 200 mg/kg body weight, 250 mg/kg body weight, and 300 mg/kg body weight, respectively. The effect on the estrous cycle was determined by vaginal lavage while routine histological preparations were done with haematoxylin-eosin stains. All values were statistically compared at appropriate confidence intervals. Estrous cycles were significantly reduced in a dose-dependent manner and histology revealed a dose-dependent toxicityinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.25 n.3 20072007-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300023en10.4067/S0717-95022007000300023
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Aspilia africana Estrous Uterine weight Histology Reproductive functions
spellingShingle	Aspilia africana Estrous Uterine weight Histology Reproductive functions Oluyemi,Kayode A Okwuonu,Uche C Baxter,D. Grillo Oyesola,Tolulope, O Toxic Effects of Methanolic Extract of Aspilia africana Leaf on the Estrous Cycle and Uterine Tissues of Wistar Rats
description	Effects of graded dosages of methanolic extract of Aspilia Africana were examined on the estrous cycle, uterine weights and histology to determine its effects on the reproductive functions of 25 cyclic female rats. The rats were randomized into five groups A, B, C, D, and E. They were given Omg/kg body weight, 150 mg/kg body weight, 200 mg/kg body weight, 250 mg/kg body weight, and 300 mg/kg body weight, respectively. The effect on the estrous cycle was determined by vaginal lavage while routine histological preparations were done with haematoxylin-eosin stains. All values were statistically compared at appropriate confidence intervals. Estrous cycles were significantly reduced in a dose-dependent manner and histology revealed a dose-dependent toxicity
author	Oluyemi,Kayode A Okwuonu,Uche C Baxter,D. Grillo Oyesola,Tolulope, O
author_facet	Oluyemi,Kayode A Okwuonu,Uche C Baxter,D. Grillo Oyesola,Tolulope, O
author_sort	Oluyemi,Kayode A
title	Toxic Effects of Methanolic Extract of Aspilia africana Leaf on the Estrous Cycle and Uterine Tissues of Wistar Rats
title_short	Toxic Effects of Methanolic Extract of Aspilia africana Leaf on the Estrous Cycle and Uterine Tissues of Wistar Rats
title_full	Toxic Effects of Methanolic Extract of Aspilia africana Leaf on the Estrous Cycle and Uterine Tissues of Wistar Rats
title_fullStr	Toxic Effects of Methanolic Extract of Aspilia africana Leaf on the Estrous Cycle and Uterine Tissues of Wistar Rats
title_full_unstemmed	Toxic Effects of Methanolic Extract of Aspilia africana Leaf on the Estrous Cycle and Uterine Tissues of Wistar Rats
title_sort	toxic effects of methanolic extract of aspilia africana leaf on the estrous cycle and uterine tissues of wistar rats
publisher	Sociedad Chilena de Anatomía
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300023
work_keys_str_mv	AT oluyemikayodea toxiceffectsofmethanolicextractofaspiliaafricanaleafontheestrouscycleanduterinetissuesofwistarrats AT okwuonuuchec toxiceffectsofmethanolicextractofaspiliaafricanaleafontheestrouscycleanduterinetissuesofwistarrats AT baxterdgrillo toxiceffectsofmethanolicextractofaspiliaafricanaleafontheestrouscycleanduterinetissuesofwistarrats AT oyesolatolulopeo toxiceffectsofmethanolicextractofaspiliaafricanaleafontheestrouscycleanduterinetissuesofwistarrats
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Toxic Effects of Methanolic Extract of Aspilia africana Leaf on the Estrous Cycle and Uterine Tissues of Wistar Rats

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