Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats

Lead is one of the most important environmental pollution which is toxic to many organ systems. D-penicillamine (D-P) is a chelator drug which is used for treatment of lead toxicity for several years. This study was conducted in order to evaluate the efficacy of D-P in reducing the effects of lead o...

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Autores principales:	Golalipour,Mohammad Jafar, Roshandel,Danial, Roshandel,Gholamreza, Ghafari,Soraya, Kalavi,Mergen, Kalavi,Khodaberdi
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2007
Materias:	Lead toxicity D-Penicillamine Recovery Blood indices Rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400008
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spelling	oai:scielo:S0717-950220070004000082008-04-15Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in RatsGolalipour,Mohammad JafarRoshandel,DanialRoshandel,GholamrezaGhafari,SorayaKalavi,MergenKalavi,Khodaberdi Lead toxicity D-Penicillamine Recovery Blood indices Rat Lead is one of the most important environmental pollution which is toxic to many organ systems. D-penicillamine (D-P) is a chelator drug which is used for treatment of lead toxicity for several years. This study was conducted in order to evaluate the efficacy of D-P in reducing the effects of lead on hematological indices. This study was done on 36 male adult, 6-8 weeks albino Wistar rats in Gorgan University of Medical Sciences. At first male adult rats were exposed to lead acetate in their drinking water. After 8 weeks, 6 rats were selected and blood samples were prepared to assess the effects of lead toxicity. The remained lead exposed rats were divided into recovery and treatment groups where distilled water and D-P was administered for them, respectively. After lead exposure, red blood cell count increased slightly, but hemoglobin and hematocrite were decreased. Also MCV and MCH were significantly decreased (P<0.05). RDW, PDW and MPV were significantly higher in lead exposed rats (P<0.05). After recovery period, most of parameters were close to normal while there were no significant differences between recovery and treatment groups. This study showed that hematologic effects of lead are reversible and D-P administration do not play an important role in subchronic lead intoxicationinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.25 n.4 20072007-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400008en10.4067/S0717-95022007000400008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Lead toxicity D-Penicillamine Recovery Blood indices Rat
spellingShingle	Lead toxicity D-Penicillamine Recovery Blood indices Rat Golalipour,Mohammad Jafar Roshandel,Danial Roshandel,Gholamreza Ghafari,Soraya Kalavi,Mergen Kalavi,Khodaberdi Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats
description	Lead is one of the most important environmental pollution which is toxic to many organ systems. D-penicillamine (D-P) is a chelator drug which is used for treatment of lead toxicity for several years. This study was conducted in order to evaluate the efficacy of D-P in reducing the effects of lead on hematological indices. This study was done on 36 male adult, 6-8 weeks albino Wistar rats in Gorgan University of Medical Sciences. At first male adult rats were exposed to lead acetate in their drinking water. After 8 weeks, 6 rats were selected and blood samples were prepared to assess the effects of lead toxicity. The remained lead exposed rats were divided into recovery and treatment groups where distilled water and D-P was administered for them, respectively. After lead exposure, red blood cell count increased slightly, but hemoglobin and hematocrite were decreased. Also MCV and MCH were significantly decreased (P<0.05). RDW, PDW and MPV were significantly higher in lead exposed rats (P<0.05). After recovery period, most of parameters were close to normal while there were no significant differences between recovery and treatment groups. This study showed that hematologic effects of lead are reversible and D-P administration do not play an important role in subchronic lead intoxication
author	Golalipour,Mohammad Jafar Roshandel,Danial Roshandel,Gholamreza Ghafari,Soraya Kalavi,Mergen Kalavi,Khodaberdi
author_facet	Golalipour,Mohammad Jafar Roshandel,Danial Roshandel,Gholamreza Ghafari,Soraya Kalavi,Mergen Kalavi,Khodaberdi
author_sort	Golalipour,Mohammad Jafar
title	Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats
title_short	Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats
title_full	Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats
title_fullStr	Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats
title_full_unstemmed	Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats
title_sort	effect of lead intoxication and d-penicillamine treatment on hematological indices in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400008
work_keys_str_mv	AT golalipourmohammadjafar effectofleadintoxicationanddpenicillaminetreatmentonhematologicalindicesinrats AT roshandeldanial effectofleadintoxicationanddpenicillaminetreatmentonhematologicalindicesinrats AT roshandelgholamreza effectofleadintoxicationanddpenicillaminetreatmentonhematologicalindicesinrats AT ghafarisoraya effectofleadintoxicationanddpenicillaminetreatmentonhematologicalindicesinrats AT kalavimergen effectofleadintoxicationanddpenicillaminetreatmentonhematologicalindicesinrats AT kalavikhodaberdi effectofleadintoxicationanddpenicillaminetreatmentonhematologicalindicesinrats
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Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats

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