A Common 34C>G Variant at the Peroxisome Proliferator-Activated Receptor γ2- Gene in Chilean Women with Polycystic Ovary Syndrome and Controls

The 34C>G (Prol2Ala) polymorphic variant of the peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) gene has been associated with polycystic ovary syndrome (PCOS). However, the results between populations are contradictory. Thus, in the present study was investigated the pos...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Guzmán,Neftalí, Erices,Leonardo, Valdés,Patricio, Salazar,Luis A
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2007
Materias:
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400030
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:scielo:S0717-95022007000400030
record_format dspace
spelling oai:scielo:S0717-950220070004000302008-04-15A Common 34C>G Variant at the Peroxisome Proliferator-Activated Receptor &#947;2- Gene in Chilean Women with Polycystic Ovary Syndrome and ControlsGuzmán,NeftalíErices,LeonardoValdés,PatricioSalazar,Luis A Polycystic ovary syndrome Peroxime proliferator-activated receptor Prol2Ala polymorphism The 34C>G (Prol2Ala) polymorphic variant of the peroxisome proliferator-activated receptor-&#947;2 (PPAR-&#947;2) gene has been associated with polycystic ovary syndrome (PCOS). However, the results between populations are contradictory. Thus, in the present study was investigated the possible association between 34C>G polymorphism at the PPAR-&#947;2 gene and PCOS in Chilean women. A total of 50 unrelated women (29.1 + 8.1 years) with diagnosis of PCOS and 75 healthy controls (29.3+ 9.3 years) were included in this study. Serum lipids, glucose and uric acid levels were determined by enzymatic-colorimetric methods. The 34C>G variant in the PPAR-&#947;2 gene was analyzed by PCR-RFLP. Women with PCOS exhibited a higher levels of glucose, total cholesterol, triglycerides, LDL-C and uric acid, and lower HDL-C levels than controls (p <0.05). The frequency of the 34G alíele was 9% in PCOS patients and 12% in control women (p = 0.589). The odds ratio for PCOS associated with 34G alíele was 0.73 (95% CI = 0.31 - 1.69) confirming the absence of association. We conclude that the 34C>G polymorphism of the PPAR-&#947;2 gene is not related to PCOS in Chilean womeninfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.25 n.4 20072007-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400030en10.4067/S0717-95022007000400030
institution Scielo Chile
collection Scielo Chile
language English
topic Polycystic ovary syndrome
Peroxime proliferator-activated receptor
Prol2Ala polymorphism
spellingShingle Polycystic ovary syndrome
Peroxime proliferator-activated receptor
Prol2Ala polymorphism
Guzmán,Neftalí
Erices,Leonardo
Valdés,Patricio
Salazar,Luis A
A Common 34C>G Variant at the Peroxisome Proliferator-Activated Receptor &#947;2- Gene in Chilean Women with Polycystic Ovary Syndrome and Controls
description The 34C>G (Prol2Ala) polymorphic variant of the peroxisome proliferator-activated receptor-&#947;2 (PPAR-&#947;2) gene has been associated with polycystic ovary syndrome (PCOS). However, the results between populations are contradictory. Thus, in the present study was investigated the possible association between 34C>G polymorphism at the PPAR-&#947;2 gene and PCOS in Chilean women. A total of 50 unrelated women (29.1 + 8.1 years) with diagnosis of PCOS and 75 healthy controls (29.3+ 9.3 years) were included in this study. Serum lipids, glucose and uric acid levels were determined by enzymatic-colorimetric methods. The 34C>G variant in the PPAR-&#947;2 gene was analyzed by PCR-RFLP. Women with PCOS exhibited a higher levels of glucose, total cholesterol, triglycerides, LDL-C and uric acid, and lower HDL-C levels than controls (p <0.05). The frequency of the 34G alíele was 9% in PCOS patients and 12% in control women (p = 0.589). The odds ratio for PCOS associated with 34G alíele was 0.73 (95% CI = 0.31 - 1.69) confirming the absence of association. We conclude that the 34C>G polymorphism of the PPAR-&#947;2 gene is not related to PCOS in Chilean women
author Guzmán,Neftalí
Erices,Leonardo
Valdés,Patricio
Salazar,Luis A
author_facet Guzmán,Neftalí
Erices,Leonardo
Valdés,Patricio
Salazar,Luis A
author_sort Guzmán,Neftalí
title A Common 34C>G Variant at the Peroxisome Proliferator-Activated Receptor &#947;2- Gene in Chilean Women with Polycystic Ovary Syndrome and Controls
title_short A Common 34C>G Variant at the Peroxisome Proliferator-Activated Receptor &#947;2- Gene in Chilean Women with Polycystic Ovary Syndrome and Controls
title_full A Common 34C>G Variant at the Peroxisome Proliferator-Activated Receptor &#947;2- Gene in Chilean Women with Polycystic Ovary Syndrome and Controls
title_fullStr A Common 34C>G Variant at the Peroxisome Proliferator-Activated Receptor &#947;2- Gene in Chilean Women with Polycystic Ovary Syndrome and Controls
title_full_unstemmed A Common 34C>G Variant at the Peroxisome Proliferator-Activated Receptor &#947;2- Gene in Chilean Women with Polycystic Ovary Syndrome and Controls
title_sort common 34c>g variant at the peroxisome proliferator-activated receptor &#947;2- gene in chilean women with polycystic ovary syndrome and controls
publisher Sociedad Chilena de Anatomía
publishDate 2007
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400030
work_keys_str_mv AT guzmanneftali acommon34cgvariantattheperoxisomeproliferatoractivatedreceptor9472geneinchileanwomenwithpolycysticovarysyndromeandcontrols
AT ericesleonardo acommon34cgvariantattheperoxisomeproliferatoractivatedreceptor9472geneinchileanwomenwithpolycysticovarysyndromeandcontrols
AT valdespatricio acommon34cgvariantattheperoxisomeproliferatoractivatedreceptor9472geneinchileanwomenwithpolycysticovarysyndromeandcontrols
AT salazarluisa acommon34cgvariantattheperoxisomeproliferatoractivatedreceptor9472geneinchileanwomenwithpolycysticovarysyndromeandcontrols
AT guzmanneftali common34cgvariantattheperoxisomeproliferatoractivatedreceptor9472geneinchileanwomenwithpolycysticovarysyndromeandcontrols
AT ericesleonardo common34cgvariantattheperoxisomeproliferatoractivatedreceptor9472geneinchileanwomenwithpolycysticovarysyndromeandcontrols
AT valdespatricio common34cgvariantattheperoxisomeproliferatoractivatedreceptor9472geneinchileanwomenwithpolycysticovarysyndromeandcontrols
AT salazarluisa common34cgvariantattheperoxisomeproliferatoractivatedreceptor9472geneinchileanwomenwithpolycysticovarysyndromeandcontrols
_version_ 1718444615584972800