Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats

The aim of the present study was to test the hypothesis that the application of fluoxetine ­ a highly selective serotonin reuptake inhibitor (SSRI) ­ in rats during the suckling period induces changes in testicular development. Groups of newborn male rats were randomly assigned with different doses...

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Autores principales: Silva Junior,Valdemiro Amaro da, Lins Amorim,Marleyne José Afonso Accioly, Amorim Junior,Adelmar Afonso de, Pinto,Catarina Ferreira, Deiró,Tereza B. J., Oliveira,João Ricardo M. de, Peixoto,Christina Alves, Manhães-de-Castro,Raul
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2008
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000100009
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spelling oai:scielo:S0717-950220080001000092009-02-02Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar RatsSilva Junior,Valdemiro Amaro daLins Amorim,Marleyne José Afonso AcciolyAmorim Junior,Adelmar Afonso dePinto,Catarina FerreiraDeiró,Tereza B. J.Oliveira,João Ricardo M. dePeixoto,Christina AlvesManhães-de-Castro,Raul Fluoxetine Testis development Sertoli cells Wistar rats The aim of the present study was to test the hypothesis that the application of fluoxetine ­ a highly selective serotonin reuptake inhibitor (SSRI) ­ in rats during the suckling period induces changes in testicular development. Groups of newborn male rats were randomly assigned with different doses of fluoxetine 24 hours after birth. Each litter stayed with its respective mother during 21 days. Body weight (BW) was measured daily from the 1st -21st day to calculate daily doses of fluoxetine. 5 mg (T1), 10 mg (T2) 20 mg (T3) or deionized water, were injected intraperitoneally. On the 21st day, animals were heparinized, anesthetized and blood was collected by cardiac puncture to determine by radioimmunoassay the follicle stimulating hormone (FSH) levels. Testis were removed, weighed, and processed for morphometric analysis. Fluoxetine groups presented decreased body and testicular weight when compared with the control group on the 21st day. Our findings show that the manipulation of the serotoninergic system with fluoxetine during the critical period of testicular development alters the Sertoli cell population and all testicular parameters related to this cell.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.26 n.1 20082008-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000100009en10.4067/S0717-95022008000100009
institution Scielo Chile
collection Scielo Chile
language English
topic Fluoxetine
Testis development
Sertoli cells
Wistar rats
spellingShingle Fluoxetine
Testis development
Sertoli cells
Wistar rats
Silva Junior,Valdemiro Amaro da
Lins Amorim,Marleyne José Afonso Accioly
Amorim Junior,Adelmar Afonso de
Pinto,Catarina Ferreira
Deiró,Tereza B. J.
Oliveira,João Ricardo M. de
Peixoto,Christina Alves
Manhães-de-Castro,Raul
Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats
description The aim of the present study was to test the hypothesis that the application of fluoxetine ­ a highly selective serotonin reuptake inhibitor (SSRI) ­ in rats during the suckling period induces changes in testicular development. Groups of newborn male rats were randomly assigned with different doses of fluoxetine 24 hours after birth. Each litter stayed with its respective mother during 21 days. Body weight (BW) was measured daily from the 1st -21st day to calculate daily doses of fluoxetine. 5 mg (T1), 10 mg (T2) 20 mg (T3) or deionized water, were injected intraperitoneally. On the 21st day, animals were heparinized, anesthetized and blood was collected by cardiac puncture to determine by radioimmunoassay the follicle stimulating hormone (FSH) levels. Testis were removed, weighed, and processed for morphometric analysis. Fluoxetine groups presented decreased body and testicular weight when compared with the control group on the 21st day. Our findings show that the manipulation of the serotoninergic system with fluoxetine during the critical period of testicular development alters the Sertoli cell population and all testicular parameters related to this cell.
author Silva Junior,Valdemiro Amaro da
Lins Amorim,Marleyne José Afonso Accioly
Amorim Junior,Adelmar Afonso de
Pinto,Catarina Ferreira
Deiró,Tereza B. J.
Oliveira,João Ricardo M. de
Peixoto,Christina Alves
Manhães-de-Castro,Raul
author_facet Silva Junior,Valdemiro Amaro da
Lins Amorim,Marleyne José Afonso Accioly
Amorim Junior,Adelmar Afonso de
Pinto,Catarina Ferreira
Deiró,Tereza B. J.
Oliveira,João Ricardo M. de
Peixoto,Christina Alves
Manhães-de-Castro,Raul
author_sort Silva Junior,Valdemiro Amaro da
title Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats
title_short Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats
title_full Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats
title_fullStr Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats
title_full_unstemmed Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats
title_sort neonatal administration of fluoxetine decreased final sertoli cell number in wistar rats
publisher Sociedad Chilena de Anatomía
publishDate 2008
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000100009
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