Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats
The aim of the present study was to test the hypothesis that the application of fluoxetine a highly selective serotonin reuptake inhibitor (SSRI) in rats during the suckling period induces changes in testicular development. Groups of newborn male rats were randomly assigned with different doses...
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Sociedad Chilena de Anatomía
2008
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oai:scielo:S0717-950220080001000092009-02-02Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar RatsSilva Junior,Valdemiro Amaro daLins Amorim,Marleyne José Afonso AcciolyAmorim Junior,Adelmar Afonso dePinto,Catarina FerreiraDeiró,Tereza B. J.Oliveira,João Ricardo M. dePeixoto,Christina AlvesManhães-de-Castro,Raul Fluoxetine Testis development Sertoli cells Wistar rats The aim of the present study was to test the hypothesis that the application of fluoxetine a highly selective serotonin reuptake inhibitor (SSRI) in rats during the suckling period induces changes in testicular development. Groups of newborn male rats were randomly assigned with different doses of fluoxetine 24 hours after birth. Each litter stayed with its respective mother during 21 days. Body weight (BW) was measured daily from the 1st -21st day to calculate daily doses of fluoxetine. 5 mg (T1), 10 mg (T2) 20 mg (T3) or deionized water, were injected intraperitoneally. On the 21st day, animals were heparinized, anesthetized and blood was collected by cardiac puncture to determine by radioimmunoassay the follicle stimulating hormone (FSH) levels. Testis were removed, weighed, and processed for morphometric analysis. Fluoxetine groups presented decreased body and testicular weight when compared with the control group on the 21st day. Our findings show that the manipulation of the serotoninergic system with fluoxetine during the critical period of testicular development alters the Sertoli cell population and all testicular parameters related to this cell.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.26 n.1 20082008-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000100009en10.4067/S0717-95022008000100009 |
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Scielo Chile |
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English |
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Fluoxetine Testis development Sertoli cells Wistar rats |
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Fluoxetine Testis development Sertoli cells Wistar rats Silva Junior,Valdemiro Amaro da Lins Amorim,Marleyne José Afonso Accioly Amorim Junior,Adelmar Afonso de Pinto,Catarina Ferreira Deiró,Tereza B. J. Oliveira,João Ricardo M. de Peixoto,Christina Alves Manhães-de-Castro,Raul Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats |
description |
The aim of the present study was to test the hypothesis that the application of fluoxetine a highly selective serotonin reuptake inhibitor (SSRI) in rats during the suckling period induces changes in testicular development. Groups of newborn male rats were randomly assigned with different doses of fluoxetine 24 hours after birth. Each litter stayed with its respective mother during 21 days. Body weight (BW) was measured daily from the 1st -21st day to calculate daily doses of fluoxetine. 5 mg (T1), 10 mg (T2) 20 mg (T3) or deionized water, were injected intraperitoneally. On the 21st day, animals were heparinized, anesthetized and blood was collected by cardiac puncture to determine by radioimmunoassay the follicle stimulating hormone (FSH) levels. Testis were removed, weighed, and processed for morphometric analysis. Fluoxetine groups presented decreased body and testicular weight when compared with the control group on the 21st day. Our findings show that the manipulation of the serotoninergic system with fluoxetine during the critical period of testicular development alters the Sertoli cell population and all testicular parameters related to this cell. |
author |
Silva Junior,Valdemiro Amaro da Lins Amorim,Marleyne José Afonso Accioly Amorim Junior,Adelmar Afonso de Pinto,Catarina Ferreira Deiró,Tereza B. J. Oliveira,João Ricardo M. de Peixoto,Christina Alves Manhães-de-Castro,Raul |
author_facet |
Silva Junior,Valdemiro Amaro da Lins Amorim,Marleyne José Afonso Accioly Amorim Junior,Adelmar Afonso de Pinto,Catarina Ferreira Deiró,Tereza B. J. Oliveira,João Ricardo M. de Peixoto,Christina Alves Manhães-de-Castro,Raul |
author_sort |
Silva Junior,Valdemiro Amaro da |
title |
Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats |
title_short |
Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats |
title_full |
Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats |
title_fullStr |
Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats |
title_full_unstemmed |
Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats |
title_sort |
neonatal administration of fluoxetine decreased final sertoli cell number in wistar rats |
publisher |
Sociedad Chilena de Anatomía |
publishDate |
2008 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000100009 |
work_keys_str_mv |
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