Acute Effects of Sulphur Mustard Gas on the Number of Lymphocytes in the Rat's Spleen

Sulphur mustard (SM), commonly known as mustard gas is an alkylating agent that causes serious blisters upon contact with human skin. SM is frequently used as a chemical warfare agent. There is some evidence for sulfur mustard-induced lymph system effects in humans. Between 2000-2001, 42 male albino...

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Autores principales:	Mehrdad,Jahanshahi, Bahadoran,H, Asadi,M. H
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2008
Materias:	Mustard gas Lymphocytes Spleen
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000200031
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spelling	oai:scielo:S0717-950220080002000312008-11-25Acute Effects of Sulphur Mustard Gas on the Number of Lymphocytes in the Rat's SpleenMehrdad,JahanshahiBahadoran,HAsadi,M. H Mustard gas Lymphocytes Spleen Sulphur mustard (SM), commonly known as mustard gas is an alkylating agent that causes serious blisters upon contact with human skin. SM is frequently used as a chemical warfare agent. There is some evidence for sulfur mustard-induced lymph system effects in humans. Between 2000-2001, 42 male albino Wistar rats were used. After accommodation with environment, we divided rats to control, sham and experimental groups (2.5 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg and 40 mg/kg). Then we injected sulphur mustard oil in rat's intraperitoneal space. Then their spleens were removed for histological verification. Our results showed that significant difference in lymphocytes number in experimental groups after 24 hours. The number of lymphocytes in 5, 10, 20 and 40 mg/kg groups was increased and this increase in 40 mg/kg group was more than the other groups. We concluded that the number of lymphocytes increased due to exposure of mustard gas and there is a relationship between the increase of lymphocytes and dose of exposure.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.26 n.2 20082008-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000200031en10.4067/S0717-95022008000200031
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Mustard gas Lymphocytes Spleen
spellingShingle	Mustard gas Lymphocytes Spleen Mehrdad,Jahanshahi Bahadoran,H Asadi,M. H Acute Effects of Sulphur Mustard Gas on the Number of Lymphocytes in the Rat's Spleen
description	Sulphur mustard (SM), commonly known as mustard gas is an alkylating agent that causes serious blisters upon contact with human skin. SM is frequently used as a chemical warfare agent. There is some evidence for sulfur mustard-induced lymph system effects in humans. Between 2000-2001, 42 male albino Wistar rats were used. After accommodation with environment, we divided rats to control, sham and experimental groups (2.5 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg and 40 mg/kg). Then we injected sulphur mustard oil in rat's intraperitoneal space. Then their spleens were removed for histological verification. Our results showed that significant difference in lymphocytes number in experimental groups after 24 hours. The number of lymphocytes in 5, 10, 20 and 40 mg/kg groups was increased and this increase in 40 mg/kg group was more than the other groups. We concluded that the number of lymphocytes increased due to exposure of mustard gas and there is a relationship between the increase of lymphocytes and dose of exposure.
author	Mehrdad,Jahanshahi Bahadoran,H Asadi,M. H
author_facet	Mehrdad,Jahanshahi Bahadoran,H Asadi,M. H
author_sort	Mehrdad,Jahanshahi
title	Acute Effects of Sulphur Mustard Gas on the Number of Lymphocytes in the Rat's Spleen
title_short	Acute Effects of Sulphur Mustard Gas on the Number of Lymphocytes in the Rat's Spleen
title_full	Acute Effects of Sulphur Mustard Gas on the Number of Lymphocytes in the Rat's Spleen
title_fullStr	Acute Effects of Sulphur Mustard Gas on the Number of Lymphocytes in the Rat's Spleen
title_full_unstemmed	Acute Effects of Sulphur Mustard Gas on the Number of Lymphocytes in the Rat's Spleen
title_sort	acute effects of sulphur mustard gas on the number of lymphocytes in the rat's spleen
publisher	Sociedad Chilena de Anatomía
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000200031
work_keys_str_mv	AT mehrdadjahanshahi acuteeffectsofsulphurmustardgasonthenumberoflymphocytesintheratsspleen AT bahadoranh acuteeffectsofsulphurmustardgasonthenumberoflymphocytesintheratsspleen AT asadimh acuteeffectsofsulphurmustardgasonthenumberoflymphocytesintheratsspleen
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Acute Effects of Sulphur Mustard Gas on the Number of Lymphocytes in the Rat's Spleen

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