Morphological Analysis of Neonates of Rats Treated with Dexamethasone in the Initial Phase of Pregnancy

The glucocorticoid dexamethasone has been largely used due to its anti-inflammatory effect. However, several authors report that the excessive exposition to it during pregnancy may cause a retard in the development in several tissues, mainly: liver, lungs and kidneys. But, the majority of the works...

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Autores principales:	Vilaça Júnior,Paulo Estevao Araújo, Teixeira,Alvaro Aguiar Coelho, Wanderley Teixeira,Valéria, Moraes,Eleonora de Figueiredo, Araújo,Ana Claudia Carvalho de, Maia,Carina Scanoni
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2008
Materias:	Pregnancy Dexamethasone Histology Rats
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300002
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spelling	oai:scielo:S0717-950220080003000022009-03-13Morphological Analysis of Neonates of Rats Treated with Dexamethasone in the Initial Phase of PregnancyVilaça Júnior,Paulo Estevao AraújoTeixeira,Alvaro Aguiar CoelhoWanderley Teixeira,ValériaMoraes,Eleonora de FigueiredoAraújo,Ana Claudia Carvalho deMaia,Carina Scanoni Pregnancy Dexamethasone Histology Rats The glucocorticoid dexamethasone has been largely used due to its anti-inflammatory effect. However, several authors report that the excessive exposition to it during pregnancy may cause a retard in the development in several tissues, mainly: liver, lungs and kidneys. But, the majority of the works are done with the application of dexamethasone in the late periods of pregnancy. Because of the lack of researches that evalúate the effects in the beginning of gestation, this paper aimed at evaluating the effect of dexamethasone administered in the initial phase of pregnancy, o ver the morphology of neonates rat. It was used 10 albino rats (Rattus norvegicus albinus) aged 90 days from the lineage Wistar. The female were coupled and divided in two groups: Group I - rats not submitted to the dexamethasone application (control); Group II - rats submitted to the dexamethasone application in the first 5 days of pregnancy. The results show that the treatment with dexamethasone in a dosage of 0.8mg/Kg during the 5 first days of pregnancy does not produces a weight and height reduction or malformation in the offspring, it does not cause changes in the development of the liver and kidneys of neonate rats, but it leads to a reduction in the denseness of the interalveolar septa causing a higher distensión of the alveoli.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.26 n.3 20082008-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300002en10.4067/S0717-95022008000300002
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Pregnancy Dexamethasone Histology Rats
spellingShingle	Pregnancy Dexamethasone Histology Rats Vilaça Júnior,Paulo Estevao Araújo Teixeira,Alvaro Aguiar Coelho Wanderley Teixeira,Valéria Moraes,Eleonora de Figueiredo Araújo,Ana Claudia Carvalho de Maia,Carina Scanoni Morphological Analysis of Neonates of Rats Treated with Dexamethasone in the Initial Phase of Pregnancy
description	The glucocorticoid dexamethasone has been largely used due to its anti-inflammatory effect. However, several authors report that the excessive exposition to it during pregnancy may cause a retard in the development in several tissues, mainly: liver, lungs and kidneys. But, the majority of the works are done with the application of dexamethasone in the late periods of pregnancy. Because of the lack of researches that evalúate the effects in the beginning of gestation, this paper aimed at evaluating the effect of dexamethasone administered in the initial phase of pregnancy, o ver the morphology of neonates rat. It was used 10 albino rats (Rattus norvegicus albinus) aged 90 days from the lineage Wistar. The female were coupled and divided in two groups: Group I - rats not submitted to the dexamethasone application (control); Group II - rats submitted to the dexamethasone application in the first 5 days of pregnancy. The results show that the treatment with dexamethasone in a dosage of 0.8mg/Kg during the 5 first days of pregnancy does not produces a weight and height reduction or malformation in the offspring, it does not cause changes in the development of the liver and kidneys of neonate rats, but it leads to a reduction in the denseness of the interalveolar septa causing a higher distensión of the alveoli.
author	Vilaça Júnior,Paulo Estevao Araújo Teixeira,Alvaro Aguiar Coelho Wanderley Teixeira,Valéria Moraes,Eleonora de Figueiredo Araújo,Ana Claudia Carvalho de Maia,Carina Scanoni
author_facet	Vilaça Júnior,Paulo Estevao Araújo Teixeira,Alvaro Aguiar Coelho Wanderley Teixeira,Valéria Moraes,Eleonora de Figueiredo Araújo,Ana Claudia Carvalho de Maia,Carina Scanoni
author_sort	Vilaça Júnior,Paulo Estevao Araújo
title	Morphological Analysis of Neonates of Rats Treated with Dexamethasone in the Initial Phase of Pregnancy
title_short	Morphological Analysis of Neonates of Rats Treated with Dexamethasone in the Initial Phase of Pregnancy
title_full	Morphological Analysis of Neonates of Rats Treated with Dexamethasone in the Initial Phase of Pregnancy
title_fullStr	Morphological Analysis of Neonates of Rats Treated with Dexamethasone in the Initial Phase of Pregnancy
title_full_unstemmed	Morphological Analysis of Neonates of Rats Treated with Dexamethasone in the Initial Phase of Pregnancy
title_sort	morphological analysis of neonates of rats treated with dexamethasone in the initial phase of pregnancy
publisher	Sociedad Chilena de Anatomía
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300002
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Morphological Analysis of Neonates of Rats Treated with Dexamethasone in the Initial Phase of Pregnancy

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