Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas
The aim of the study was to determine the immunohistochemical expression of the PCNA, p53 and bcl-2 proteins in pleomorphic adenomas.onineteen specimens of pleomorphic adenomas were selected for analysis by the streptavidin-biotin-peroxidase method with antibodies againstp53, PCNA and bcl-2 proteins...
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| Lenguaje: | English |
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Sociedad Chilena de Anatomía
2008
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oai:scielo:S0717-950220080003000102009-03-13Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic AdenomasGordón-Núñez,Manuel AntonioGodoy,Gustavo PinaSoares,Rosilene CalazansSouza,Lélia Batista deFreitas,Roseana de AlmeidaQueiroz,Lélia María Guedes Pleomorphic adenoma Salivary gland tumour p53 PCNA bcl-2 The aim of the study was to determine the immunohistochemical expression of the PCNA, p53 and bcl-2 proteins in pleomorphic adenomas.onineteen specimens of pleomorphic adenomas were selected for analysis by the streptavidin-biotin-peroxidase method with antibodies againstp53, PCNA and bcl-2 proteins. It was observedweak labeling for p53 in 12 cases (63.1%) andforPCNA in 8 (42.1%). With respect to the bcl-2 labeling index,ono expression of this protein was detected in 12 cases, corresponding to 63.1% of the sample. Based on these findings, it was concluded that p53 and PCNA can favor the proliferative activity of pleomorphic adenomas, whereas bcl-2 probably doesonot effectively particípate in the pathogenesis of this tumor.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.26 n.3 20082008-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300010en10.4067/S0717-95022008000300010 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Pleomorphic adenoma Salivary gland tumour p53 PCNA bcl-2 |
| spellingShingle |
Pleomorphic adenoma Salivary gland tumour p53 PCNA bcl-2 Gordón-Núñez,Manuel Antonio Godoy,Gustavo Pina Soares,Rosilene Calazans Souza,Lélia Batista de Freitas,Roseana de Almeida Queiroz,Lélia María Guedes Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas |
| description |
The aim of the study was to determine the immunohistochemical expression of the PCNA, p53 and bcl-2 proteins in pleomorphic adenomas.onineteen specimens of pleomorphic adenomas were selected for analysis by the streptavidin-biotin-peroxidase method with antibodies againstp53, PCNA and bcl-2 proteins. It was observedweak labeling for p53 in 12 cases (63.1%) andforPCNA in 8 (42.1%). With respect to the bcl-2 labeling index,ono expression of this protein was detected in 12 cases, corresponding to 63.1% of the sample. Based on these findings, it was concluded that p53 and PCNA can favor the proliferative activity of pleomorphic adenomas, whereas bcl-2 probably doesonot effectively particípate in the pathogenesis of this tumor. |
| author |
Gordón-Núñez,Manuel Antonio Godoy,Gustavo Pina Soares,Rosilene Calazans Souza,Lélia Batista de Freitas,Roseana de Almeida Queiroz,Lélia María Guedes |
| author_facet |
Gordón-Núñez,Manuel Antonio Godoy,Gustavo Pina Soares,Rosilene Calazans Souza,Lélia Batista de Freitas,Roseana de Almeida Queiroz,Lélia María Guedes |
| author_sort |
Gordón-Núñez,Manuel Antonio |
| title |
Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas |
| title_short |
Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas |
| title_full |
Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas |
| title_fullStr |
Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas |
| title_full_unstemmed |
Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas |
| title_sort |
inmunohistochemical expression of pcna, p53 and bcl-2 in pleomorphic adenomas |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2008 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300010 |
| work_keys_str_mv |
AT gordonnunezmanuelantonio inmunohistochemicalexpressionofpcnap53andbcl2inpleomorphicadenomas AT godoygustavopina inmunohistochemicalexpressionofpcnap53andbcl2inpleomorphicadenomas AT soaresrosilenecalazans inmunohistochemicalexpressionofpcnap53andbcl2inpleomorphicadenomas AT souzaleliabatistade inmunohistochemicalexpressionofpcnap53andbcl2inpleomorphicadenomas AT freitasroseanadealmeida inmunohistochemicalexpressionofpcnap53andbcl2inpleomorphicadenomas AT queirozleliamariaguedes inmunohistochemicalexpressionofpcnap53andbcl2inpleomorphicadenomas |
| _version_ |
1718444631226580992 |