Histological and Functional Organization in Human Testicle: Expression of Receptors c-kit and Androgens

The objective of this work was identify the presence of interstitial cells of Cajal, muscle cells, nerves and androgen receptor positive cells in adult human testicle, using immunohistochemical detection for c-kit/CD-117, actin smooth muscle specific (ASMS), neurofilament (N) and androgen receptor (...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rodríguez,H, Espinoza-Navarro,O, Sarabia,L, Tamayo,C, Sepúlveda,M, Inostroza,J, Araya,J. C, Moriguchi,K
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2008
Materias:	Human reproduction Testicle Interstitial Cajal cells Tubular motility AR
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300015
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022008000300015
record_format	dspace
spelling	oai:scielo:S0717-950220080003000152009-03-13Histological and Functional Organization in Human Testicle: Expression of Receptors c-kit and AndrogensRodríguez,HEspinoza-Navarro,OSarabia,LTamayo,CSepúlveda,MInostroza,JAraya,J. CMoriguchi,K Human reproduction Testicle Interstitial Cajal cells Tubular motility AR The objective of this work was identify the presence of interstitial cells of Cajal, muscle cells, nerves and androgen receptor positive cells in adult human testicle, using immunohistochemical detection for c-kit/CD-117, actin smooth muscle specific (ASMS), neurofilament (N) and androgen receptor (AR), respectively. The samples were obtained from patients (n= 10) with diagnosis of prostate cáncer, with surgery of orchiectomy. Subsequently were processed by histology and for immunohistochemistry using specific antibodies. It showed the presence of cells c-kit/CD-117, with diverse degrees of positivity, distributed mainly in the interstitial peritubular área of the human testicle. The peritubular myoides cells were positive to the presence of the actin smooth muscle and androgen receptor. The neurofilaments elements (+) only were observed in the vascular tunic. The specific immunohistochemistry describe the presence of the interstitial cells of Cajal in human testicular interstitium, opening a new perspective for the functional interpretation of the testicular cellularity and tubular motility. Possibly associated functionally to peribubulars cells of smooth muscle to regúlate the mobility of the seminiferous tabules, whose integration and function would be androgen dependent. The cells that express the c-kit receptor, were found exclusively in the interstitial compartment. This cellular type in addition of the muscular cells of peritubules and the absence of nervous fibers to the interior of the testicle, could be responsible for the regulation of tubular mobility, as it happens in the gastrointestinal apparatus.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.26 n.3 20082008-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300015en10.4067/S0717-95022008000300015
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Human reproduction Testicle Interstitial Cajal cells Tubular motility AR
spellingShingle	Human reproduction Testicle Interstitial Cajal cells Tubular motility AR Rodríguez,H Espinoza-Navarro,O Sarabia,L Tamayo,C Sepúlveda,M Inostroza,J Araya,J. C Moriguchi,K Histological and Functional Organization in Human Testicle: Expression of Receptors c-kit and Androgens
description	The objective of this work was identify the presence of interstitial cells of Cajal, muscle cells, nerves and androgen receptor positive cells in adult human testicle, using immunohistochemical detection for c-kit/CD-117, actin smooth muscle specific (ASMS), neurofilament (N) and androgen receptor (AR), respectively. The samples were obtained from patients (n= 10) with diagnosis of prostate cáncer, with surgery of orchiectomy. Subsequently were processed by histology and for immunohistochemistry using specific antibodies. It showed the presence of cells c-kit/CD-117, with diverse degrees of positivity, distributed mainly in the interstitial peritubular área of the human testicle. The peritubular myoides cells were positive to the presence of the actin smooth muscle and androgen receptor. The neurofilaments elements (+) only were observed in the vascular tunic. The specific immunohistochemistry describe the presence of the interstitial cells of Cajal in human testicular interstitium, opening a new perspective for the functional interpretation of the testicular cellularity and tubular motility. Possibly associated functionally to peribubulars cells of smooth muscle to regúlate the mobility of the seminiferous tabules, whose integration and function would be androgen dependent. The cells that express the c-kit receptor, were found exclusively in the interstitial compartment. This cellular type in addition of the muscular cells of peritubules and the absence of nervous fibers to the interior of the testicle, could be responsible for the regulation of tubular mobility, as it happens in the gastrointestinal apparatus.
author	Rodríguez,H Espinoza-Navarro,O Sarabia,L Tamayo,C Sepúlveda,M Inostroza,J Araya,J. C Moriguchi,K
author_facet	Rodríguez,H Espinoza-Navarro,O Sarabia,L Tamayo,C Sepúlveda,M Inostroza,J Araya,J. C Moriguchi,K
author_sort	Rodríguez,H
title	Histological and Functional Organization in Human Testicle: Expression of Receptors c-kit and Androgens
title_short	Histological and Functional Organization in Human Testicle: Expression of Receptors c-kit and Androgens
title_full	Histological and Functional Organization in Human Testicle: Expression of Receptors c-kit and Androgens
title_fullStr	Histological and Functional Organization in Human Testicle: Expression of Receptors c-kit and Androgens
title_full_unstemmed	Histological and Functional Organization in Human Testicle: Expression of Receptors c-kit and Androgens
title_sort	histological and functional organization in human testicle: expression of receptors c-kit and androgens
publisher	Sociedad Chilena de Anatomía
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300015
work_keys_str_mv	AT rodriguezh histologicalandfunctionalorganizationinhumantesticleexpressionofreceptorsckitandandrogens AT espinozanavarroo histologicalandfunctionalorganizationinhumantesticleexpressionofreceptorsckitandandrogens AT sarabial histologicalandfunctionalorganizationinhumantesticleexpressionofreceptorsckitandandrogens AT tamayoc histologicalandfunctionalorganizationinhumantesticleexpressionofreceptorsckitandandrogens AT sepulvedam histologicalandfunctionalorganizationinhumantesticleexpressionofreceptorsckitandandrogens AT inostrozaj histologicalandfunctionalorganizationinhumantesticleexpressionofreceptorsckitandandrogens AT arayajc histologicalandfunctionalorganizationinhumantesticleexpressionofreceptorsckitandandrogens AT moriguchik histologicalandfunctionalorganizationinhumantesticleexpressionofreceptorsckitandandrogens
_version_	1718444632191270912

Histological and Functional Organization in Human Testicle: Expression of Receptors c-kit and Androgens

Ejemplares similares