Sesame radiatum Phytoestrogens Stimulate Spermatogenic Activity and Improve Sperm Quality in Adult Male Sprague Dawley Rat Testis
Increasing concern has been expressed about the declining sperm count of humans and the potential environmental effects of both synthetic and natural estrogenic endocrine disruptors (EEDs) on human reproductive health in the last few decades. However, due to paucity of knowledge, we evaluate the chr...
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| Lenguaje: | English |
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Sociedad Chilena de Anatomía
2008
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oai:scielo:S0717-950220080003000222009-03-13Sesame radiatum Phytoestrogens Stimulate Spermatogenic Activity and Improve Sperm Quality in Adult Male Sprague Dawley Rat TestisShittu,Lukeman, A. J.Shittu,Remilekun, K.Adesite,Samson, O.Ajala,M. OluwoleBankole,Munir, A.Benebo,A. S.Tayo,A. O.Ogundipe,Olufemi, A.Ashiru,Oladapo, A. Testis Sesame leaves Histopathology Hormonal assay Seminal analysis SD Rats Increasing concern has been expressed about the declining sperm count of humans and the potential environmental effects of both synthetic and natural estrogenic endocrine disruptors (EEDs) on human reproductive health in the last few decades. However, due to paucity of knowledge, we evaluate the chronic reproductive toxicity of sesame phytoestrogenic lignans on the male Sprague Dawley (SD) rats' testis. Thirty adult male SD rats weighing 150-200g were divided into three groups. Two treated groups received a daily dose of aqueous leaves extract of Sesamum radiatum at 14.0 mg/kg bw and 28.0mg /kg bw respectively via gastric gavage, while equal volume of normal saline was administered to the control group for six weeks. Seminal analysis and hormonal assay study were analyzed using SPSS software and P< 0.05 was considered statistically significant. The results showed significant (P< 0.05) body weight gains observed in all the animals with significant (P< 0.05) weight increase in their raw testicular weights compared to control. The relative testicular weight per 100g bw was significantly (P< 0.05) higher in control than treated. However, theweight gain was dose related with a reversal in their relative testicular weight. The cauda sperm count including the motility and morphology of the treated were significantly (P< 0.05) higher than control in a dose related manner. In addition, significant (P > 0.05) increases in testosterone and a significant decrease in FSH in the high dose (treated) compared to control. Sesame phytoestrogenic lignans improves spermatozoa quality in a dose related manner.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.26 n.3 20082008-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300022en10.4067/S0717-95022008000300022 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Testis Sesame leaves Histopathology Hormonal assay Seminal analysis SD Rats |
| spellingShingle |
Testis Sesame leaves Histopathology Hormonal assay Seminal analysis SD Rats Shittu,Lukeman, A. J. Shittu,Remilekun, K. Adesite,Samson, O. Ajala,M. Oluwole Bankole,Munir, A. Benebo,A. S. Tayo,A. O. Ogundipe,Olufemi, A. Ashiru,Oladapo, A. Sesame radiatum Phytoestrogens Stimulate Spermatogenic Activity and Improve Sperm Quality in Adult Male Sprague Dawley Rat Testis |
| description |
Increasing concern has been expressed about the declining sperm count of humans and the potential environmental effects of both synthetic and natural estrogenic endocrine disruptors (EEDs) on human reproductive health in the last few decades. However, due to paucity of knowledge, we evaluate the chronic reproductive toxicity of sesame phytoestrogenic lignans on the male Sprague Dawley (SD) rats' testis. Thirty adult male SD rats weighing 150-200g were divided into three groups. Two treated groups received a daily dose of aqueous leaves extract of Sesamum radiatum at 14.0 mg/kg bw and 28.0mg /kg bw respectively via gastric gavage, while equal volume of normal saline was administered to the control group for six weeks. Seminal analysis and hormonal assay study were analyzed using SPSS software and P< 0.05 was considered statistically significant. The results showed significant (P< 0.05) body weight gains observed in all the animals with significant (P< 0.05) weight increase in their raw testicular weights compared to control. The relative testicular weight per 100g bw was significantly (P< 0.05) higher in control than treated. However, theweight gain was dose related with a reversal in their relative testicular weight. The cauda sperm count including the motility and morphology of the treated were significantly (P< 0.05) higher than control in a dose related manner. In addition, significant (P > 0.05) increases in testosterone and a significant decrease in FSH in the high dose (treated) compared to control. Sesame phytoestrogenic lignans improves spermatozoa quality in a dose related manner. |
| author |
Shittu,Lukeman, A. J. Shittu,Remilekun, K. Adesite,Samson, O. Ajala,M. Oluwole Bankole,Munir, A. Benebo,A. S. Tayo,A. O. Ogundipe,Olufemi, A. Ashiru,Oladapo, A. |
| author_facet |
Shittu,Lukeman, A. J. Shittu,Remilekun, K. Adesite,Samson, O. Ajala,M. Oluwole Bankole,Munir, A. Benebo,A. S. Tayo,A. O. Ogundipe,Olufemi, A. Ashiru,Oladapo, A. |
| author_sort |
Shittu,Lukeman, A. J. |
| title |
Sesame radiatum Phytoestrogens Stimulate Spermatogenic Activity and Improve Sperm Quality in Adult Male Sprague Dawley Rat Testis |
| title_short |
Sesame radiatum Phytoestrogens Stimulate Spermatogenic Activity and Improve Sperm Quality in Adult Male Sprague Dawley Rat Testis |
| title_full |
Sesame radiatum Phytoestrogens Stimulate Spermatogenic Activity and Improve Sperm Quality in Adult Male Sprague Dawley Rat Testis |
| title_fullStr |
Sesame radiatum Phytoestrogens Stimulate Spermatogenic Activity and Improve Sperm Quality in Adult Male Sprague Dawley Rat Testis |
| title_full_unstemmed |
Sesame radiatum Phytoestrogens Stimulate Spermatogenic Activity and Improve Sperm Quality in Adult Male Sprague Dawley Rat Testis |
| title_sort |
sesame radiatum phytoestrogens stimulate spermatogenic activity and improve sperm quality in adult male sprague dawley rat testis |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2008 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300022 |
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