The Ameriorating Effects of Grapefruit Seed Extract on Testicular Morphology and Function of Varicocelized Rats

Varicoceles are abnormal tortuosity and dilatation of the veins of the pampiniform plexus that drain the testis.The pathophysiology of testicular damage in varicocele has not been completely understood. However there is an increasing body of evidence pointing towards the role of reactive oxygen spec...

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Autores principales:	Saalu,,L. C, Udeh,R., Oluyemi,K. A, Jewo,P. I, Fadeyibi,L. O
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2008
Materias:	Varicocele Grapefruit seed extract Testis Infertility
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000400042
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spelling	oai:scielo:S0717-950220080004000422009-05-25The Ameriorating Effects of Grapefruit Seed Extract on Testicular Morphology and Function of Varicocelized RatsSaalu,,L. CUdeh,R.Oluyemi,K. AJewo,P. IFadeyibi,L. O Varicocele Grapefruit seed extract Testis Infertility Varicoceles are abnormal tortuosity and dilatation of the veins of the pampiniform plexus that drain the testis.The pathophysiology of testicular damage in varicocele has not been completely understood. However there is an increasing body of evidence pointing towards the role of reactive oxygen species and oxidative stress in the pathogenesis of varicocele related subfertility. In the present study we examined the role of proanthocynidin-rich ethanol extract of grapefruit seed as an antioxidant in protecting the testis against damage in experimental varicocele. Three groups of rats were constructed as the first group had intact rats; experimental bilateral varicoceles were established by complete ligation of the left and right main spermatic veins in the later two groups. The third group had in addition daily gavage administration of 1 Omg/ kg body weight ethanol extract of grapefruit seed. Eight weeks after varicocele induction, bilateral testicular weights, bilateral testicular volumes, bilateral caudal epididymal sperm characteristics, and bilateral testicular histology and serum hormone levéis were tested. It was found that the testes of grapefruit seed extract treated animáis had better functional and histological profiles compared to the untreated varicocelized animáis. These results indicated the effectiveness of grapefruit seed extract for preservation of testes function morphology in varicocelized subjects.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.26 n.4 20082008-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000400042en10.4067/S0717-95022008000400042
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Varicocele Grapefruit seed extract Testis Infertility
spellingShingle	Varicocele Grapefruit seed extract Testis Infertility Saalu,,L. C Udeh,R. Oluyemi,K. A Jewo,P. I Fadeyibi,L. O The Ameriorating Effects of Grapefruit Seed Extract on Testicular Morphology and Function of Varicocelized Rats
description	Varicoceles are abnormal tortuosity and dilatation of the veins of the pampiniform plexus that drain the testis.The pathophysiology of testicular damage in varicocele has not been completely understood. However there is an increasing body of evidence pointing towards the role of reactive oxygen species and oxidative stress in the pathogenesis of varicocele related subfertility. In the present study we examined the role of proanthocynidin-rich ethanol extract of grapefruit seed as an antioxidant in protecting the testis against damage in experimental varicocele. Three groups of rats were constructed as the first group had intact rats; experimental bilateral varicoceles were established by complete ligation of the left and right main spermatic veins in the later two groups. The third group had in addition daily gavage administration of 1 Omg/ kg body weight ethanol extract of grapefruit seed. Eight weeks after varicocele induction, bilateral testicular weights, bilateral testicular volumes, bilateral caudal epididymal sperm characteristics, and bilateral testicular histology and serum hormone levéis were tested. It was found that the testes of grapefruit seed extract treated animáis had better functional and histological profiles compared to the untreated varicocelized animáis. These results indicated the effectiveness of grapefruit seed extract for preservation of testes function morphology in varicocelized subjects.
author	Saalu,,L. C Udeh,R. Oluyemi,K. A Jewo,P. I Fadeyibi,L. O
author_facet	Saalu,,L. C Udeh,R. Oluyemi,K. A Jewo,P. I Fadeyibi,L. O
author_sort	Saalu,,L. C
title	The Ameriorating Effects of Grapefruit Seed Extract on Testicular Morphology and Function of Varicocelized Rats
title_short	The Ameriorating Effects of Grapefruit Seed Extract on Testicular Morphology and Function of Varicocelized Rats
title_full	The Ameriorating Effects of Grapefruit Seed Extract on Testicular Morphology and Function of Varicocelized Rats
title_fullStr	The Ameriorating Effects of Grapefruit Seed Extract on Testicular Morphology and Function of Varicocelized Rats
title_full_unstemmed	The Ameriorating Effects of Grapefruit Seed Extract on Testicular Morphology and Function of Varicocelized Rats
title_sort	ameriorating effects of grapefruit seed extract on testicular morphology and function of varicocelized rats
publisher	Sociedad Chilena de Anatomía
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000400042
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The Ameriorating Effects of Grapefruit Seed Extract on Testicular Morphology and Function of Varicocelized Rats

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