Morphological Characteristics and Haematological Studies in Wistar Rats Subjected to Prolonged Treatment of Chloramphenicol

The morphological characteristics and haematological studies were studied in fifteen male albino rats (Wistar Strain) aged between 12 and 14 weeks and with a body weight of 150- 180g. The rats were allowed to feed on commercially prepared rat pellet and provided with fresh water ad libitum. The rats...

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Autores principales:	Oyeyemi,Matthew Olugbenga, Adeniji,Deborah Adejoke
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2009
Materias:	Chloramphenicol Breeding Spermatozoa Wistar rats Infertility
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100001
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spelling	oai:scielo:S0717-950220090001000012009-06-24Morphological Characteristics and Haematological Studies in Wistar Rats Subjected to Prolonged Treatment of ChloramphenicolOyeyemi,Matthew OlugbengaAdeniji,Deborah Adejoke Chloramphenicol Breeding Spermatozoa Wistar rats Infertility The morphological characteristics and haematological studies were studied in fifteen male albino rats (Wistar Strain) aged between 12 and 14 weeks and with a body weight of 150- 180g. The rats were allowed to feed on commercially prepared rat pellet and provided with fresh water ad libitum. The rats were divided into three groups; the rats were in groups A, B and C of 5 rats each. Group A served as control of the study; Group B was treated with Chloramphenicol at the dose rate of 25mg/kg body weight per os for 20 days; while Group C was treated for 25 days. Semen used in this study was obtained from the caudal epididymides while morphological aberrations were determined from spermatozoa counted after stained with Wells and Awa stain. Results of the spermiogram showed that the volume was decreasing as the prolonged dosage of chloramphenicol increases. The percentage motility in Group A (89.0 + 2.45%), differed significantly (p < 0.05) when compared to Group B (72.0 + 3.74%) and Group C (66.0 + 2.45%). The same pattern is observed in percentage liveability, morphological aberration and sperm concentration. This indicates that prolonged dosage of chloramphenicol will cause infertility in male animals. It is therefore concluded and recommended that prolonged dosage of chloramphenicol can cause infertility and or sterility. So it should not be used in male animals meant for mature breeding and artificial insemination programme.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.27 n.1 20092009-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100001en10.4067/S0717-95022009000100001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Chloramphenicol Breeding Spermatozoa Wistar rats Infertility
spellingShingle	Chloramphenicol Breeding Spermatozoa Wistar rats Infertility Oyeyemi,Matthew Olugbenga Adeniji,Deborah Adejoke Morphological Characteristics and Haematological Studies in Wistar Rats Subjected to Prolonged Treatment of Chloramphenicol
description	The morphological characteristics and haematological studies were studied in fifteen male albino rats (Wistar Strain) aged between 12 and 14 weeks and with a body weight of 150- 180g. The rats were allowed to feed on commercially prepared rat pellet and provided with fresh water ad libitum. The rats were divided into three groups; the rats were in groups A, B and C of 5 rats each. Group A served as control of the study; Group B was treated with Chloramphenicol at the dose rate of 25mg/kg body weight per os for 20 days; while Group C was treated for 25 days. Semen used in this study was obtained from the caudal epididymides while morphological aberrations were determined from spermatozoa counted after stained with Wells and Awa stain. Results of the spermiogram showed that the volume was decreasing as the prolonged dosage of chloramphenicol increases. The percentage motility in Group A (89.0 + 2.45%), differed significantly (p < 0.05) when compared to Group B (72.0 + 3.74%) and Group C (66.0 + 2.45%). The same pattern is observed in percentage liveability, morphological aberration and sperm concentration. This indicates that prolonged dosage of chloramphenicol will cause infertility in male animals. It is therefore concluded and recommended that prolonged dosage of chloramphenicol can cause infertility and or sterility. So it should not be used in male animals meant for mature breeding and artificial insemination programme.
author	Oyeyemi,Matthew Olugbenga Adeniji,Deborah Adejoke
author_facet	Oyeyemi,Matthew Olugbenga Adeniji,Deborah Adejoke
author_sort	Oyeyemi,Matthew Olugbenga
title	Morphological Characteristics and Haematological Studies in Wistar Rats Subjected to Prolonged Treatment of Chloramphenicol
title_short	Morphological Characteristics and Haematological Studies in Wistar Rats Subjected to Prolonged Treatment of Chloramphenicol
title_full	Morphological Characteristics and Haematological Studies in Wistar Rats Subjected to Prolonged Treatment of Chloramphenicol
title_fullStr	Morphological Characteristics and Haematological Studies in Wistar Rats Subjected to Prolonged Treatment of Chloramphenicol
title_full_unstemmed	Morphological Characteristics and Haematological Studies in Wistar Rats Subjected to Prolonged Treatment of Chloramphenicol
title_sort	morphological characteristics and haematological studies in wistar rats subjected to prolonged treatment of chloramphenicol
publisher	Sociedad Chilena de Anatomía
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100001
work_keys_str_mv	AT oyeyemimatthewolugbenga morphologicalcharacteristicsandhaematologicalstudiesinwistarratssubjectedtoprolongedtreatmentofchloramphenicol AT adenijideborahadejoke morphologicalcharacteristicsandhaematologicalstudiesinwistarratssubjectedtoprolongedtreatmentofchloramphenicol
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Morphological Characteristics and Haematological Studies in Wistar Rats Subjected to Prolonged Treatment of Chloramphenicol

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